PEOPLE

Edimara Da Silva Reis, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationUniversity of Pennsylvania
422 Curie Blvd.
401 Stellar Chance Labs
Philadelphia, PA 19104
Office: 215-746-5760

Education

M.Sc (Immunology), University of Sao Paulo, 2004
PhD (Immunology), University of Sao Paulo, 2008

Specialty Certification

Certificate in Clinical Research, Invitare, Sao Paulo, Brazil, 2015

Postgraduate Training

Fellow in Complement Immunology, Cincinnati Children’s Medical Center, Cincinnati, OH, 2006-2007
Immunology, Institute for Systemic Inflammation Research, University of Lubeck, Germany, 2008-2010
Immunology/ Biochemistry, Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 2011-2013
Visiting Scientist, Complement Biology, Department of Immunology, University of Sao Paulo, Sao Paulo, Brazil, 2013-2015

Awards and Honors

International Research Stipend Award, CAPES, Brazil, 2006
Trainee Travel Award; Immunology Graduate Program, USP, Brazil, 2007
Trainee Travel Award; 6th International Conference on Innate Immunity, Crete, Greece, 2008
Trainee Travel Award; XXIV International Complement Workshop, Crete, Greece, 2012

Memberships and Professional Organizations

Brazilian Society of Immunology, 2001 - 2008
Penn Institute for Immunology, 2015 - Present

Web Links


Selected Publications

Pericyte and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Xavier Sandhya, Sahu Ranjit K, Landes Susan G, Yu Jing, Taylor Ronald P, Ayyadevara Srinivas, Megyesi Judit, Stallcup William B, Duffield Jeremy S, Reis Edimara S, Lambris John D, Portilla Didier, American journal of physiology. Renal physiology, 2017, PMID:28052876

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Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS.

Primikyri Alexandra, Papanastasiou Malvina, Sarigiannis Yiannis, Koutsogiannaki Sophia, Reis Edimara S, Tuplano Joel V, Resuello Ranillo R G, Nilsson Bo, Ricklin Daniel, Lambris John D, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1041-1042(): 19-26, 2016, PMID:27992787

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Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense.

Ricklin Daniel, Reis Edimara S, Mastellos Dimitrios C, Gros Piet, Lambris John D, Immunological reviews 274(1): 33-58, 2016, PMID:27782325

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Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia.

Lindorfer Margaret A, Cook Erika M, Reis Edimara S, Ricklin Daniel, Risitano Antonio M, Lambris John D, Taylor Ronald P, Clinical immunology 171(): 32-35, 2016, PMID:27546448

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From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.

Mastellos Dimitrios C, Reis Edimara S, Yancopoulou Despina, Hajishengallis George, Ricklin Daniel, Lambris John D, Immunobiology 221(10): 1046-57, 2016, PMID:27353192

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High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity.

Doerner Stephanie K, Reis Edimara S, Leung Elaine S, Ko Justine S, Heaney Jason D, Berger Nathan A, Lambris John D, Nadeau Joseph H, Molecular cancer research 14(10): 953-965, 2016, PMID:27535705

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Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration.

Min Jun S, DeAngelis Robert A, Reis Edimara S, Gupta Shakti, Maurya Mano R, Evans Charles, Das Arun, Burant Charles, Lambris John D, Subramaniam Shankar, Journal of immunology 197(6): 2500-8, 2016, PMID:27511733

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Complement in disease: a defence system turning offensive.

Ricklin Daniel, Reis Edimara S, Lambris John D, Nature reviews. Nephrology 12(7): 383-401, 2016, PMID:27211870

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Applying complement therapeutics to rare diseases.

Reis Edimara S, Mastellos Dimitrios C, Yancopoulou Despina, Risitano Antonio M, Ricklin Daniel, Lambris John D, Clinical immunology 161(2): 225-40, 2015, PMID:26341313

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Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity.

Sfyroera Georgia, Ricklin Daniel, Reis Edimara S, Chen Hui, Wu Emilia L, Kaznessis Yiannis N, Ekdahl Kristina N, Nilsson Bo, Lambris John D, Journal of immunology 194(7): 3305-16, 2015, PMID:25712219

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