PEOPLE

Bruce L. Levine, PhD

Barbara and Edward Netter Professor in Cancer Gene Therapy
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard

Philadelphia, PA, 19104
Office: 215-746-1481

Email: levinebl@pennmedicine.upenn.edu

Specialty Division

Transfusion Medicine & Therapeutic Pathology

Research Expertise

Immunology, Cell and Gene Therapy

Other Expertise

Good Manufacturing Practices

Itmat Expertise

Dr. Levine's interests include cell, gene, and biologic therapy clinical trial development, manufacturing, and testing and lymphocyte growth, activation and senescence.

Education

B.A. (Major-Biology, Minor-History), The University of Pennsylvania , 1984
Ph.D. (Immunology and Infectious Diseases), The Johns Hopkins University, 1992

Specialty Certification

Postgraduate Training

Post-doctoral Fellow, Henry M. Jackson Foundation, Naval Medical Research Institute, National Naval Medical Center, Bethesda, MD, 1992-1996

Awards and Honors

Honorable Mention, The Frederik Bang Award for Student Research, 1991
Sustained Superior Performance Award, 1997. The Henry M. Jackson Foundation, 1995
New Investigator Award, Clinical Immunology Society, 1997
Dynal Literature Award for 1996, 1997
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2004
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2007
Highest Rated Scientific Abstract (blinded review), International Society for Cellular Therapy 17th Annual Meeting, 2011
Discover Magazine Top 100 Stories of 2011: #2 Designer Cells Block HIV, http://discovermagazine.com/2012/jan-feb/02; #10 Leukemia Cure, http://discovermagazine.com/2012/jan-feb/10, 2011
Science Translational Medicine Top Downloaded paper for 2011, "T cells with chimerical antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia", 2012
Dr. Audrey E. Evans Award of Excellence, Philadelphia Ronald McDonald House, 2014
Best Oral Abstract Award, International Society for Cellular Therapy Annual Meeting, 2015
Clinical Research Achievement Award from the Clinical Research Forum for Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV, 2015
Best Oral Abstract Award, International Society for Cellular Therapy Annual Meeting, 2016
William Osler Patient Oriented Research Award from the University of Pennsylvania Perelman School of Medicine, 2018
Clinical Research Achievement Award from the Clinical Research Forum for "Predicting response of patients with chronic lymphocytic leukemia to chimeric antigen receptor (CAR) T cell therapy", 2019
Wallace H. Coulter Award for Healthcare Innovation, Biomedical Engineering Society, 2019
Healthnetwork Foundation Service Excellence Award, 2019
"The Medicine Maker" Power List, 2019

Memberships and Professional Organizations

American Society of Gene Therapy, 1999 - Present
International Society for Cellular Therapy, 1999 - present
American Association for the Advancement of Science, 2002 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, 2003 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2004 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, 2004 - Present
NIH Study Section, Immunology Integrated Review Group SSS-4 SBIR/STTR, 2004 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2005 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2005 - Present
NIH/NIAID Clinical Trial Planning (R34) Grants Study Section, 2006 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2006 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2007 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2007 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2008 - Present
Coordinating Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2008 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2009 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2010 - Present
NIH/NHLBI Program: Production Assistance for Cellular Therapies, 2010 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2010.1.4-1: Translational research on cell-based immunotherapy" Brussels, Belgium, 2010 - 2011
Cambridge Healthtech Institute, 2010 - Present
American Society for Gene and Cell Therapy, 2011 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2012.1.4-4: "Targeted nucleic acid delivery as an innovative therapeutic or prophylactic approach" Brussels, Belgium, 2011 - 2012
Cancer Prevention and Research Institute of Texas: Texas Access to Cancer Cell Therapies (TACCT), 2014 - Present
Israel Science Foundation, 2018 - Present
National Heart Lung and Blood Institute Cure Sickle Cell Initiative, 2019 - 2020

Web Links


Selected Publications

CRISPR-engineered T cells in patients with refractory cancer.

Stadtmauer Edward A, Fraietta Joseph A, Davis Megan M, Cohen Adam D, Weber Kristy L, Lancaster Eric, Mangan Patricia A, Kulikovskaya Irina, Gupta Minnal, Chen Fang, Tian Lifeng, Gonzalez Vanessa E, Xu Jun, Jung In-Young, Melenhorst J Joseph, Plesa Gabriela, Shea Joanne, Matlawski Tina, Cervini Amanda, Gaymon Avery L, Desjardins Stephanie, Lamontagne Anne, Salas-Mckee January, Fesnak Andrew, Siegel Donald L, Levine Bruce L, Jadlowsky Julie K, Young Regina M, Chew Anne, Hwang Wei-Ting, Hexner Elizabeth O, Carreno Beatriz M, Nobles Christopher L, Bushman Frederic D, Parker Kevin R, Qi Yanyan, Satpathy Ansuman T, Chang Howard Y, Zhao Yangbing, Lacey Simon F, June Carl H, Science (New York, N.Y.), 2020, PMID:32029687

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Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia.

Frey Noelle V, Shaw Pamela A, Hexner Elizabeth O, Pequignot Edward, Gill Saar, Luger Selina M, Mangan James K, Loren Alison W, Perl Alexander E, Maude Shannon L, Grupp Stephan A, Shah Nirav N, Gilmore Joan, Lacey Simon F, Melenhorst Jos J, Levine Bruce L, June Carl H, Porter David L, Journal of clinical oncology : official journal of the American Society of Clinical Oncology 38(5): 415-422, 2020, PMID:31815579

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CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration.

Nobles Christopher L, Sherrill-Mix Scott, Everett John K, Reddy Shantan, Fraietta Joseph A, Porter David L, Frey Noelle, Gill Saar I, Grupp Stephan A, Maude Shannon L, Siegel Donald L, Levine Bruce L, June Carl H, Lacey Simon F, Melenhorst J Joseph, Bushman Frederic D, The Journal of clinical investigation 130(2): 673-685, 2020, PMID:31845905

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T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma.

Garfall Alfred L, Dancy Ehren K, Cohen Adam D, Hwang Wei-Ting, Fraietta Joseph A, Davis Megan M, Levine Bruce L, Siegel Don L, Stadtmauer Edward A, Vogl Dan T, Waxman Adam, Rapoport Aaron P, Milone Michael C, June Carl H, Melenhorst J Joseph, Blood advances 3(19): 2812-2815, 2019, PMID:31575532

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CAR T cell viability release testing and clinical outcomes: is there a lower limit?

Chong Elise A, Levine Bruce L, Grupp Stephan A, Davis Megan M, Siegel Don L, Maude Shannon L, Gladney Whitney L, Frey Noelle V, Porter David L, Hwang Wei-Ting, Chong Emeline R, June Carl H, Schuster Stephen J, Blood, 2019, PMID:31554634

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A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies.

Wang Kan, Liu Y I, Li Junxuan, Wang Ben, Bishop Reid, White Chip, DAS Amritava, Levine Aaron D, Ho Linda, Levine Bruce L, Fesnak Andrew D, Cytotherapy, 2019, PMID:31445816

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Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L, Molecular therapy : the journal of the American Society of Gene Therapy, 2019, PMID:31420241

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B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

Cohen Adam D, Garfall Alfred L, Stadtmauer Edward A, Melenhorst J Joseph, Lacey Simon F, Lancaster Eric, Vogl Dan T, Weiss Brendan M, Dengel Karen, Nelson Annemarie, Plesa Gabriela, Chen Fang, Davis Megan M, Hwang Wei-Ting, Young Regina M, Brogdon Jennifer L, Isaacs Randi, Pruteanu-Malinici Iulian, Siegel Don L, Levine Bruce L, June Carl H, Milone Michael C, The Journal of Clinical Investigation 130(): 126397, 2019, PMID:30896447

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Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

Stein Andrew M, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith J, Levine Bruce L, Tomassian Lori, Shah Sweta, Leung Mimi, Huang Pai-Hsi, Awasthi Rakesh, Mueller Karen Thudium, Wood Patricia A, June Carl H, CPT: pharmacometrics & systems pharmacology, 2019, PMID:30848084

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Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods.

Harrison Richard P, Zylberberg Ezequiel, Ellison Simon, Levine Bruce L, Cytotherapy 21(2): 224-233, 2019, PMID:30770285

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