PEOPLE

Bruce L. Levine, PhD

Barbara and Edward Netter Professor in Cancer Gene Therapy
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard

Philadelphia, PA, 19104
Office: 215-746-1481

Email: levinebl@pennmedicine.upenn.edu

Specialty Division

Transfusion Medicine & Therapeutic Pathology

Research Expertise

Immunology, Cell and Gene Therapy

Other Expertise

Good Manufacturing Practices

Itmat Expertise

Dr. Levine's interests include cell, gene, and biologic therapy clinical trial development, manufacturing, and testing and lymphocyte growth, activation and senescence.

Education

B.A. (Major-Biology, Minor-History), The University of Pennsylvania , 1984
Ph.D. (Immunology and Infectious Diseases), The Johns Hopkins University, 1992

Specialty Certification

Postgraduate Training

Post-doctoral Fellow, Henry M. Jackson Foundation, Naval Medical Research Institute, National Naval Medical Center, Bethesda, MD, 1992-1996

Awards and Honors

Honorable Mention, The Frederik Bang Award for Student Research, 1991
Sustained Superior Performance Award, 1997. The Henry M. Jackson Foundation, 1995
New Investigator Award, Clinical Immunology Society, 1997
Dynal Literature Award for 1996, 1997
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2004
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2007
Discover Magazine Top 100 Stories of 2011: #2 Designer Cells Block HIV, http://discovermagazine.com/2012/jan-feb/02; #10 Leukemia Cure, http://discovermagazine.com/2012/jan-feb/10, 2011
Highest Rated Scientific Abstract (blinded review), International Society for Cellular Therapy 17th Annual Meeting, 2011
Science Translational Medicine Top Downloaded paper for 2011, "T cells with chimerical antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia", 2012
Dr. Audrey E. Evans Award of Excellence, Philadelphia Ronald McDonald House, 2014
Clinical Research Achievement Award from the Clinical Research Forum for Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV, 2015
Best Oral Abstract Award, International Society for Cellular Therapy Annual Meeting, 2015
Best Oral Abstract Award, International Society for Cellular Therapy Annual Meeting, 2016
William Osler Patient Oriented Research Award from the University of Pennsylvania Perelman School of Medicine, 2018
"The Medicine Maker" Power List, 2019
Wallace H. Coulter Award for Healthcare Innovation, Biomedical Engineering Society, 2019
Healthnetwork Foundation Service Excellence Award, 2019
Clinical Research Achievement Award from the Clinical Research Forum for "Predicting response of patients with chronic lymphocytic leukemia to chimeric antigen receptor (CAR) T cell therapy", 2019

Memberships and Professional Organizations

American Society of Gene Therapy, 1999 - Present
International Society for Cellular Therapy, 1999 - present
American Association for the Advancement of Science, 2002 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, 2003 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2004 - Present
NIH Study Section, Immunology Integrated Review Group SSS-4 SBIR/STTR, 2004 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, 2004 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2005 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2005 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2006 - Present
NIH/NIAID Clinical Trial Planning (R34) Grants Study Section, 2006 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2007 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2007 - Present
Coordinating Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2008 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2008 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2009 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2010.1.4-1: Translational research on cell-based immunotherapy" Brussels, Belgium, 2010 - 2011
NIH/NHLBI Program: Production Assistance for Cellular Therapies, 2010 - Present
Cambridge Healthtech Institute, 2010 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2010 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2012.1.4-4: "Targeted nucleic acid delivery as an innovative therapeutic or prophylactic approach" Brussels, Belgium, 2011 - 2012
American Society for Gene and Cell Therapy, 2011 - Present
Cancer Prevention and Research Institute of Texas: Texas Access to Cancer Cell Therapies (TACCT), 2014 - Present
National Heart Lung and Blood Institute Cure Sickle Cell Initiative, 2019 - 2020

Web Links


Selected Publications

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma.

Garfall Alfred L, Dancy Ehren K, Cohen Adam D, Hwang Wei-Ting, Fraietta Joseph A, Davis Megan M, Levine Bruce L, Siegel Don L, Stadtmauer Edward A, Vogl Dan T, Waxman Adam, Rapoport Aaron P, Milone Michael C, June Carl H, Melenhorst J Joseph, Blood advances 3(19): 2812-2815, 2019, PMID:31575532

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CAR T cell viability release testing and clinical outcomes: is there a lower limit?

Chong Elise A, Levine Bruce L, Grupp Stephan A, Davis Megan M, Siegel Don L, Maude Shannon L, Gladney Whitney L, Frey Noelle V, Porter David L, Hwang Wei-Ting, Chong Emeline R, June Carl H, Schuster Stephen J, Blood, 2019, PMID:31554634

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A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies.

Wang Kan, Liu Y I, Li Junxuan, Wang Ben, Bishop Reid, White Chip, DAS Amritava, Levine Aaron D, Ho Linda, Levine Bruce L, Fesnak Andrew D, Cytotherapy, 2019, PMID:31445816

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Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L, Molecular therapy : the journal of the American Society of Gene Therapy, 2019, PMID:31420241

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B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

Cohen Adam D, Garfall Alfred L, Stadtmauer Edward A, Melenhorst J Joseph, Lacey Simon F, Lancaster Eric, Vogl Dan T, Weiss Brendan M, Dengel Karen, Nelson Annemarie, Plesa Gabriela, Chen Fang, Davis Megan M, Hwang Wei-Ting, Young Regina M, Brogdon Jennifer L, Isaacs Randi, Pruteanu-Malinici Iulian, Siegel Don L, Levine Bruce L, June Carl H, Milone Michael C, The Journal of Clinical Investigation 130(): 126397, 2019, PMID:30896447

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Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

Stein Andrew M, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith J, Levine Bruce L, Tomassian Lori, Shah Sweta, Leung Mimi, Huang Pai-Hsi, Awasthi Rakesh, Mueller Karen Thudium, Wood Patricia A, June Carl H, CPT: pharmacometrics & systems pharmacology, 2019, PMID:30848084

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Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods.

Harrison Richard P, Zylberberg Ezequiel, Ellison Simon, Levine Bruce L, Cytotherapy 21(2): 224-233, 2019, PMID:30770285

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Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia.

Mueller Karen T, Waldron Edward R, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith, Hamilton Jason, Awasthi Rakesh, Stein Andrew M, Sickert Denise, Chakraborty Abhijit, Levine Bruce L, June Carl H, Tomassian Lori, Shah Sweta, Leung Mimi, Taran Tetiana, Wood Patricia A, Maude Shannon L, Clinical Cancer Research 24(24): 6175, 2018, PMID:30190371

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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.

Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ, Nature Medicine 24(10): 1499-1503, 2018

Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells

Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC, Cancer Immunol Res. 6(9): 100-1109, 2018