PEOPLE

Bruce L. Levine, PhD

Barbara and Edward Netter Professor in Cancer Gene Therapy
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Advanced Cell Therapies
South Tower, Building 421, 9th floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-898-9120

Email: levinebl@mail.med.upenn.edu

Specialty Division

Transfusion Medicine & Therapeutic Pathology, Immunobiology and Experimental Pathology

Research Expertise

Immunology, Cell and Gene Therapy

Other Expertise

Good Manufacturing Practices

Itmat Expertise

Dr. Levine's interests include cell, gene, and biologic therapy clinical trial development, manufacturing, and testing and lymphocyte growth, activation and senescence.

Education

B.A. (Major-Biology, Minor-History), The University of Pennsylvania , 1984
Ph.D. (Immunology and Infectious Diseases), The Johns Hopkins University, 1992

Specialty Certification

Postgraduate Training

Post-doctoral Fellow, Henry M. Jackson Foundation, Naval Medical Research Institute, National Naval Medical Center, Bethesda, MD, 1992-1996

Awards and Honors

Honorable Mention, The Frederik Bang Award for Student Research, 1991
Sustained Superior Performance Award, 1997. The Henry M. Jackson Foundation, 1995
New Investigator Award, Clinical Immunology Society, 1997
Dynal Literature Award for 1996, 1997
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2004
Best Abstract Award International Society for Cellular Therapy Annual Meeting, 2007
Discover Magazine Top 100 Stories of 2011: #2 Designer Cells Block HIV, http://discovermagazine.com/2012/jan-feb/02; #10 Leukemia Cure, http://discovermagazine.com/2012/jan-feb/10, 2011
Highest Rated Scientific Abstract (blinded review), International Society for Cellular Therapy 17th Annual Meeting, 2011
Science Translational Medicine Top Downloaded paper for 2011, "T cells with chimerical antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia", 2012
Dr. Audrey E. Evans Award of Excellence, Philadelphia Ronald McDonald House, 2014
Clinical Research Achievement Award from the Clinical Research Forum for Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV, 2015
Best Oral Abstract Award, International Society for Cellular Therapy Annual Meeting, 2015

Memberships and Professional Organizations

International Society for Cellular Therapy, 1999 - present
American Society of Gene Therapy, 1999 - Present
American Association for the Advancement of Science, 2002 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, 2003 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, 2004 - Present
NIH Study Section, Immunology Integrated Review Group SSS-4 SBIR/STTR, 2004 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2004 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2005 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2005 - Present
NIH/NIAID Clinical Trial Planning (R34) Grants Study Section, 2006 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2006 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2007 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2007 - Present
Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, 2008 - Present
Coordinating Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2008 - Present
NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, 2009 - Present
Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, 2010 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2010.1.4-1: Translational research on cell-based immunotherapy" Brussels, Belgium, 2010 - 2011
NIH/NHLBI Program: Production Assistance for Cellular Therapies, 2010 - Present
Cambridge Healthtech Institute, 2010 - Present
European Commission review panel for FP7 Cooperation Work Programme "HEALTH.2012.1.4-4: "Targeted nucleic acid delivery as an innovative therapeutic or prophylactic approach" Brussels, Belgium, 2011 - 2012
American Society for Gene and Cell Therapy, 2011 - Present
Cancer Prevention and Research Institute of Texas: Texas Access to Cancer Cell Therapies (TACCT), 2014 - Present

Web Links


Selected Publications

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia.

Mueller Karen Thudium, Maude Shannon L, Porter David L, Frey Noelle, Wood Patricia, Han Xia, Waldron Edward, Chakraborty Abhijit, Awasthi Rakesh, Levine Bruce L, Melenhorst J Joseph, Grupp Stephan A, June Carl H, Lacey Simon F, Blood, 2017, PMID:28935694

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai, Jan J. Melenhorst, Keith Mansfield, Jennifer J. D. Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen, Randi Isaacs, Suyash Mohan, Gabriela Plesa, Simon F. Lacey, Jean-Marc Navenot, Zhaohui Zheng, Bruce L. Levine, Hideho Okada, Carl H. June, Jennifer L. Brogdon and Marcela V. Maus, Science Translational Medicine 9(399): eaaa0984, 2017

Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function

Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT, Barrett DM, Cytotherapy 19(7): 867, 2017, PMID:28506444

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PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

Chong Elise A, Melenhorst J Joseph, Lacey Simon F, Ambrose David E, Gonzalez Vanessa, Levine Bruce L, June Carl H, Schuster Stephen J, Blood 129(8): 1039-1041, 2017, PMID:28031179

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Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials.

McKenna David H, Sumstad Darin, Kadidlo Diane M, Batdorf Bjorn, Lord Colin J, Merkel Sarah C, Koellner Christine M, Curtsinger Julie M, June Carl H, Riley James L, Levine Bruce L, Miller Jeffrey S, Brunstein Claudio G, Wagner John E, Blazar Bruce R, Hippen Keli L, Cytotherapy 19(2): 250-262, 2016, PMID:27887864

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miR-146b antagomir treated human Tregs increase TRAF6-NFkB expression, suppressor function and GVHD inhibitory potency.

Lu Yunjie, Hippen Keli L, Lemire Amanda L, Gu Jian, Wang Weizhi, Ni Xuhao, Ranganathan Parvathi, Levine Bruce L, Riley James L, June Carl H, Turka Laurence A, Munn David H, Garzon Ramiro, Lu Ling, Blazar Bruce R, Blood 128(10): 1424-35, 2016, PMID:27485827

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Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia.

Teachey David T, Lacey Simon F, Shaw Pamela A, Melenhorst J Joseph, Maude Shannon L, Frey Noelle, Pequignot Edward, Gonzalez Vanessa E, Chen Fang, Finklestein Jeffrey, Barrett David M, Weiss Scott L, Fitzgerald Julie C, Berg Robert A, Aplenc Richard, Callahan Colleen, Rheingold Susan R, Zheng Zhaohui, Rose-John Stefan, White Jason C, Nazimuddin Farzana, Wertheim Gerald, Levine Bruce L, June Carl H, Porter David L, Grupp Stephan A, Cancer discovery 6(6): 664-79, 2016, PMID:27076371

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Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.

Hexner Elizabeth O, Luger Selina M, Reshef Ran, Jeschke Grace R, Mangan James K, Frey Noelle V, Frank Dale M, Richman Lee P, Vonderheide Robert H, Aqui Nicole A, Rosenbach Misha, Zhang Yi, Chew Anne, Loren Alison W, Stadtmauer Edward A, Levine Bruce L, June Carl H, Emerson Stephen G, Porter David L, American journal of hematology 91(5): 453-60, 2016, PMID:26858124

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Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

Fraietta JA, Beckwith KA, Patel PR, Ruella M, Zheng Z, Barrett DM, Lacey SF, Melenhorst JJ, McGettigan SE, Cook DR, Zhang C, Xu J, Do P, Hulitt J, Kudchodkar SB, Cogdill AP, Gill S, Porter DL, Woyach JA, Long M, Johnson AJ, Maddocks K, Muthusamy N, Levine BL, June CH, Byrd JC, Maus MV, Blood 127(9): 1117, 2016, PMID:26813675

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Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect.

Brunstein Claudio G, Miller Jeffrey S, McKenna David H, Hippen Keli L, DeFor Todd E, Sumstad Darin, Curtsinger Julie, Verneris Michael R, MacMillan Margaret L, Levine Bruce L, Riley James L, June Carl H, Le Chap, Weisdorf Daniel J, McGlave Philip B, Blazar Bruce R, Wagner John E, Blood 127(8): 1044-51, 2016, PMID:26563133

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