PEOPLE

Peter F. Davies, PhD, ScD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815

Email: pfd@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics, computational fluid dynamics, endocardial endothelium and 4D-flow MRI.

CVI Expertise

Research Interests
Cell and molecular biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular phenotyping, membrane biophysics, to biomechanics, computational fluid dynamics, genomics, epigenomics, 4-D flow MRI and endocardial endothelial phenotypes.

Other Expertise

Biophysics; Lipid metabolism

Itmat Expertise

Dr. Davies is interested in how temporal and spatial hemodynamics regulates cell and molecular phenotyping of endothelial cell physiology and pathology.

Graduate Groups

Cell and Molecular Biology
Pharmacology

Education

B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.)), University of Newcastle-upon-Tyne, 1969
M.Sc. (Biochemistry), University of Victoria, B.C., Canada, 1972
Ph.D. (Experimental Pathology), University of Cambridge, 1975
Sc.D. (Higher Doctorate), University of Cambridge, 2015

Specialty Certification

Postgraduate Training

Postdoctoral Research (Exptl. Path), Cambridge University, UK, 1975-1976
Senior Research Fellow (Cellular Pathology), University of Washington, Seattle, USA, 1977-1978

Awards and Honors

International Exchange Scholar, University of Wageningen, Netherlands, 1968-1968
UK Science Research Council Cooperative Award in Pure Science, Cambridge University, 1972-1975
NIH grant awards (RO1; PPG; SCOR; Training Grants); AHA Grant in Aid, 1978
Member, NHLBI Research Review Committee B, 1986-1990
Awardee, Louis Block Fund for Basic Research and Advanced Study, University of Chicago, 1988-1989
Chairman, Gordon Research Conference on Atherosclerosis, 1990-1991
Chairman, AHA Vascular Wall Biology Research Study Committee, 1991-1999
Director, NIH Cardiovascular Pathophysiology and Biochemistry
Training Grant, The University of Chicago, 1991-1996
Member, American Heart Association (AHA) National Research Committee, Dallas, 1992-1995
NIH MERIT Award, 1993-2003
The Vaishnav Lecture, Catholic University, Washington DC, 1994
Spudich Lecture, American Heart Association, 1995
Vice-Chair 1995-7, AHA National Research Committee, Dallas, 1995-1997
Elected Fellow, American Institute for Medical and Biological Engineering FAIMBE, 1996
M.A.(honoris causa), University of Pennsylvania, 1996
Guest Editor J. Biomechanics, 1996-1996
SpaceLabs Medical Lecture, American Society Hypertension in Pregnancy, 1996
Chairman 1997-99, AHA National Research Committee, Dallas, 1997-1999
CARIM Medal and Lecture, University of Maastricht, Netherlands, 1997
Distinguished Lecturer in Biomechanical Engineering, Stanford University, 1998
Inaugural Lecturer, A.C. Suhren-Whitaker Lecture Series in Tissue Engineering, Tulane University, 1998
2nd Benjamin Zweifach Memorial Lecturer in Biomedical Engineering, CCNY, 2000
Special Recognition Award, American Heart Association ATVB Council, 2000
Elected Fellow of the American Heart Association FAHA, 2001
Member, Japan Physiome Project, 2001-2004
Member of US-Russia Cardiology Delegation (NHLBI), 2001
Guest Editor, Circulation Research, 2002-2003
Endothelome Lecture, Japan Physiome Project, Sapporo, Japan, 2003
Paulette Shirey Pritchett Endowed Lecture in Pathology, Univ. of Alabama, 2003
2004 Senior Research Scientist Award
AHA Mid-Atlantic Region, 2004
Bio-X Lecture, Frontiers in Interdisciplinary Biosciences. Stanford University, 2004
Endowed Chair: Robinette Foundation Professor of Cardiovascular Medicine, 2005-2015
Distinguished Lecturer in Bioengineering, University of California at Berkeley, 2006
2007 Haust Lecturer in Cell and Molecular Pathology, Queens University, Canada, 2007
Elected to Board of Directors, National Space Biomedical Research Institute (NASA), 2007
Member, NIH Study Section, R21 Innovation Grants, NHLBI, 2008-2010
Member, NIH Study Section; K99/R00 Pathway to Independence Awards, NHLBI, 2009-2013
Member, NIH Study Section Hypertension and Microcirculation, NHLBI, 2009
Visiting Fellow (by invitation)
Isaac Newton Institute for Mathematical Sciences, Cambridge University, UK, 2009-2009
Member, HHMI Review Panel
Med into Grad Training Program
Howard Hughes Medical Institute, 2009
Appointed to College of CSR Reviewers, NIH, 2010
Special Dean's Award, University of Pennsylvania School of Medicine. Medical Educational Leadership (for HHMI-NIH Interfaces Program), 2010
Invited State-of-the Art. AXA Inaugural Chair Symposium. Ecole Polytechnique, Paris, 2010
10th Ramzi Cotran Memorial Lecturer, Harvard Medical School, 2011
Biomedical Postdoctoral Programs Distinguished Mentorship Award, University of Pennsylvania School of Medicine, 2011
Member, HHMI Review Committee
International Fellowship Program, 2011
Plenary Speaker, British Atherosclerosis Society, Queens College, Cambridge University, 2011
Dean's Distinguished Lecturer, College of Medicine, University of Kentucky, Lexington, 2012
Keynote Speaker, British Heart Foundation Center of Excellence, Imperial College, London, 2012
Distinguished Keynote Lecture, Frontiers in Cardiovascular Biology, European Society of Cardiology, London, 2012
Plenary Speaker, International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, Atlanta, 2012
2013 Netherlands Heart Foundation Lecturer, Erasmus University, Rotterdam, 2013
Keynote Speaker, McGill University Systems Biology Symposium. Montreal, 2013
B.Lowell Langille Memorial Lecturer, University of Toronto, 2013
Keynote Speaker, 6th Biennial Heart Valve Biology & Tissue Engineering Meeting, Royal Society, London, 2014
Standing Member (4yrs), Mentored Transition to Independence Review Committee,
National Heart Lung & Blood Istitute, NIH. 2014-2018, 2014
2014 Hugh Sinclair Memorial Lecturer, British Atherosclerosis Society, Queens College, University of Cambridge, 2014
Higher Doctorate (Sc.D.) awarded for Distinguished Research in Science, University of Cambridge, 2016
Keynote Speaker, 2nd Joint Meeting European Vascular Biology Organization/Euro Microcirculation Society.
“Hemodynamics and Systems Biology of Blood Vesssels." Geneva, Switzerland. May, 2017-2017
Elected Fellow American Association for the Advancement of Science (AAAS), 2017
Keynote Speaker, 2nd Joint Meeting European Vascular Biology Organization/Euro Microcirculation Society.
“Hemodynamics and Systems Biology of Blood Vesssels”. Geneva, Switzerland, 2017
2018 Richard Skalak Memorial Lecturer in Biomedical Engineering, UCSD, 2018

Memberships and Professional Organizations

Council on Basic Cardiovascular Sciences (AHA)2001, 2001 - Present
HHMI International Student Dissertation Research Fellowship Program, 2010 - Present
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, - Present
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, Budget Committee, - Present
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, Program Committee, - Present
AHA: Council for High Blood Pressure Research, - Present
AHA: Council on Basic Cardiovascular Sciences, - Present
AHA: Basic Science Council, - Present
AHA: National Research Committee, - Present
AHA: National Research Committee, - Present
AHA: Fellowship Awards Symposium, - Present
AHA: Vascular Wall Biology Research Study Committee, - Present
AHA: Research Program Evaluation Committee (RPEC), - Present
AHA: Scientific Advisory Council, - Present
AHA: SACC Task Force on New Research Initiatives, - Present
AHA: Nominating and Awards Committee, - Present
AHA-Metropolitan Chicago, Grant Review Committee, - Present
AHA: Lipoprotein, Lipid Metabolism and Epidemiology Research Study Committee (National), - Present
AHA: Inter-Council Working Group on Vascular Biology, - Present
Genomics and Computational Biology Graduate Group, University of Pennsylvania, - Present
Advisory Board, International Vascular Biology Meeting 2000, Geneva, Switzerland, - Present
Hong Kong Government Medical Research Program, - Present
Science and Technology Commission, University of Virginia, - Present
AAAS Annual Meeting Science Innovation Subcommittee, - Present
Council for Medical and Health Research of the Netherlands Organization for Scientific Research, - Present
US-Israel Binational Research Grant Program, - Present
NIH Delegation, US-Russia Symposium on Basic Research in Cardiovascular and Pulmonary Diseases, Moscow, 2001, - Present
NIH Cardiovascular Sciences IRG Study Section Boundary Team, 2001, - Present
Smart Medical Systems Team, National Space Biomedical Research Institute (NSBRI), 2001-present, - Present
Scientific Advisory Committee, Penn Proteomics Initiative, 2002-present, - Present
Scientific Advisory Committee, Port of Technology (Life Sciences), U. Pennsylvania 2002-present, - Present
Scientific Advisory Board, Clinigenetics, Nimes, France, 2001-present, - Present
Science Foundation Ireland (SFI) Medical Research Program, 2003-present, - Present
NHLBI Program Projects and SCORs, SCOR Parent Committee, - Present
The Wellcome Trust (UK). Wellcome Senior Research Fellowships, - Present
Veterans Administration Hospitals. Project grant reviews, - Present
Cardiovascular Review Committee, Tobacco Related Diseases Research Program for the State of California, - Present
External Advisory Committee, Vascular Smooth Muscle Program Project, University of Virginia, - Present
Biochemical Society, London, - Present
American Society for Cell Biology (ASCB), - Present
American Society of the Advancement of Science (AAAS), - Present
Arteriosclerosis Council, American Heart Assocation (AHA), - Present
American Association of Pathologists (AAP)/American Society for Investigative Pathology (ASIP), - Present
New York Academy of Sciences, - Present
Basic Science Council (AHA), - Present
Sigma Xi, - Present
American Physiology Society, - Present
American Institute for Medical and Biological Engineering (AIMBE), - Present
Biomedical Engineering Society, - Present
Hypertension Council (AHA), - Present
John Morgan Society, - Present
Biophysical Society, - Present
AHA: Subgroup D, Fellowship Review Committee, - Present
Scientific Advisory Committee, Whitaker Foundation, - Present
NASA: Microgravity Sciences Applications Division, Space Station Freedom, Biotechnology Program Johnson Space Center, - Present
NASA: Gravitational Influences on Mechano Transduction, Life Sciences Division, Washington, - Present
NASA: Cardiovascular Alterations Workshop, National Space Biomedical Research Institute, Houston, - Present
National Science Foundation: NSF proposals, - Present
North American Vascular Biology Organization (NAVBO): Executive Council, - Present
Interenational Advisory Board, Japanese Physiome Project, - Present
Florence Medical, Tel Aviv, Israel, - Present
Georgia Tech–Emory University, Department of Biomedical Engineering, - Present
Bioengineering Graduate Group, University of Pennsylvania, - Present
NHLBI Research Review Committee B, - Present
NHLBI Special Study Sections and Special Emphasis Panels, - Present
NHLBI Program Projects and SCORs, - Present
“Proatherosclerotic Genes”, NHLBI RFA Task Force, - Present
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, - Present

Web Links


Selected Publications

Biofluids, Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of endothelial gene expression.

Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z, Journal of Biomechanics 50(): 3-10, 2017

Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF., Journal of Biomechanics 50(): 11-19, 2017

In: LabStudio: Design Research Between Architecture & Biology. Sabin J and Jones P. Pub: Routledge / Taylor and Francis (2016). In Press.

Davies P.F., Routledge / Taylor and Francis In Press(In Press): , 2017

Endothelial epigenetics and its role in mediating biomechanical stress of hypertension.

Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ, J. Hypertension 34; Suppl 1-ISH 2016(): e371, 2016

Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF., J Am Heart Assoc 18;5(4). pii: e003170.(): doi: 10.1161/JAHA.115.003170, 2016

Lymph flow regulates collecting lymphatic vessel maturation in vivo

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML., J. Clin Invest. 125(): 2995-3007, 2015

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR., J Controlled Release 210(): 39-47, 2015

Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF., BMC Genomics 16(): 506, 2015

Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR., Am. Chem. Soc. Nano. 9(7): 6785-6793, 2015

Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF., Arterioscler Thromb Vasc Biol 35(): 1317-1326, 2015

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