PEOPLE

Abd Al-Roof Higazi, MD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationPathology and Laboratory Medicine
512 Stellar Chance Building
422 Curie Blvd
Philadelphia, PA 19104
Office: 215-662-7757

Email: higazi@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Itmat Expertise

I have directed an NIH sponsored laboratory for over 15 years with a focus on plasminogen activators. We have identified several extrafibrinolytic activities of the tissue-type plasminogen activator (tPA) and urokinase (uPA), including their effects on vascular tone and blood flow. We have identified the responsible vascular receptors and intracellular signal transduction pathways. With this knowledge and the appropriate animal models at hand, we developed several peptides and PA variants that inhibit these vascular changes in settings where these actions are deleterious. Our recent work has focused on applying this knowledge from understanding the pathophysiology and management of stroke and traumatic brain injury to acute lung injury (ALI).

Education

M.D. (Medicine), Faculta de Medicina de la Univesidad de Barcelona, 1984

Postgraduate Training

Internship, Hadassah University Hospital, Jerusalem, 1985-1986
Internship in Clinical Biochemistry, Hadassah University Hospital, Jerusalem, 1986-1990
First Stage Residency Examination in Clinical Biochemistry, Hadassah University Hospital, Jerusalem, 1989-
Consultant Clinical Biochemistry, Hadassah University Hospital, Mount Scopus, 1990-1994
Second Stage Residency Examination in Clinical Biochemistry, Hadassah University Hospital, Jerusalem, 1990-
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 1994-1996

Awards and Honors

Faculta de Medicina de la Universidad De Barcelona, Distinction Award in Biochemistry and General Physiology, 1979

Memberships and Professional Organizations

Fogarty International Research Collaboration Award (FIRCA)Study Section of the National Institutes of Health (USA), 2003 - Present
NIH Study Section-Brain Injury and Neovascular pathologies., 2006 - 2008
18th International Congress on Fibrinolysis and Proteolysis, 2006 - Present
NIH Study section-Hemostasis and Thrombosis, 2006 - 2008