PEOPLE

Kaori Ihida-Stansbury, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationInstitute for Medicine and Engineering
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: 215-898-7554
Fax: 215-573-6815

Specialty Division

Immunobiology and Experimental Pathology

CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
My long term interest is to define the signaling pathway from extracellular
matrix to cell signaling for the cell fate in the lung in development and
disease.

Itmat Expertise

My research interest is to understand how microenvironmental cues regulate stem/progenitor cell differentiation. Currently, my research is focusing on lung vascular SMC differentiation controlled by extracellular matrix properties: stiffness (biophysical property) and TGF-beta signaling (biochemical property). To examine this, I have utilized a decellularized lung scaffolds culture system and determine 3-D matrix signal on cell differentiation. In the long term, I hope that the information gathered using this approach will provide fundamental information necessary to understand the regeneration of the lung and to design more effective therapies.

Education

BS (Pharmacy), Nagasaki University, Nagasaki, Japan, 1984
PhD (Biomedical Science), Kagoshima University, Kagoshima, Japan, 1993

Specialty Certification

Postgraduate Training

Postdoctoral fellow, School of Medicine, University of California at San Diego, CA, 1993-1997
Postdoctoral fellow, Dept. Pediatrics, University of Colorado Health Sciences Center, Denver, 2002-2003
Instructor Fellow, Dept. Pediatrics, University of Colorado Health Sciences Center, 2003-2005

Awards and Honors

Young Scientist Award:
Kodama Foundation for Research of Medical Science, 1990
Grant-in-Aid, Ministry of Education, Science and Culture, Japan
For young scientist, 1991
Young Scientist Award:
Kodama Foundation for Research of Medical Science, 1992
Grant-in-Aid, Ministry of Education, Science and Culture, Japan
For young scientist, 1993
NIH postdoctoral fellow, 2003-2005
Young Investigator Award:
American Heart Association, Pennsylvania Affiliate, 2006
Pennvetion semifinalist, 2015

Memberships and Professional Organizations

American Society for Cell Biology, 2002 - Present
North American Vascular Biology Organization, 2003 - Present
Pulmonary Hypertension Association, 2005 - Present
University of Pennsylvania Cardiovascular Institute, 2008 - Present
University of Pennsylvania Regenerative Medicine Institute, 2009 - Present
University of Pennsylvania, Center for Engineering and Cell Regeneration, 2009 - Present
Penn Center for Musculoskeletal Disorders, 2011 - Present
Penn Institute for Translational Medicine & Therapeutics, 2011 - present
American Thoracic Society, 2012 - present
American Physiology Society, 2013 - Present

Web Links


Selected Publications

Myeloid Cell 5-lipoxygenase activating protein modulates the response to vascular injury

Yu, Z., Ricciotti, E., Ihida-Stansbury, K., Stubbe, J., Hawthorne, E.A., Jones, L., Assoian, R., Fitzgerald, G., Circ. Res. 112(): 432-440, 2013, PMID:23250985

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The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

Reichert, M., Takano, S., von Burstin, J., Kim, SB., Lee, JS., Ihida-Stansbury, K., Hahn, C., Heeg, S., Schneider, G., Rhim, AD., Stanger, BZ., Rustgi, AK., Genes Dev 27(): 288-300, 2013

Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling.

Chow,K., Fessel, J., Ihida-Stansbury, K., Schmidt, E., Gaskill, C., Alvarez, D., Graham, B., Harrison, D., Wanger, D., Nozik-Grayck, D., West, J., Klemm, D., Majka, S., Pulm. Circ. 3(1): 31-49, 2013

Polarization-based non-staining cell detection

Zhang, M., Ihida-Stansbury, K., Van Der Spiegel, J., Engheta, N., Opt. Express 20(): 25378-25390, 2012

Altered Expression of Nuclear and Cytoplasmic Histone H1 in Pulmonary Artery and Pulmonary Artery Smooth Muscle Cells in Patients with IPAH

Talati M, Seeley E, Ihida-Stansbury K, Delisser H, McDonald H, Ye F, Zhang X, Shyr Y, Caprioli R, Meyrick B, members of the Pulmonary Hypertension Breakthrough Initiative, Pulm. Circ. 2(): 340-351, 2012, PMID:23130102

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mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

Krymskaya, V.P., Snow, J., Cesarone, G., Khavin, I., Goncharov, D.A., Lim, P., Veasey, S.C., Ihida-Stansbury, K., Jones, P.L., Goncharov, E, FASEB J 25(): 1922-1933, 2011, PMID:21368105

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Microsomal prostaglandin E2 synthase-1 modulates the response to vascular injury.

Wang, M., Ihida-Stansbury, K., Kothapalli, D., Tamby M.C., Yu, Z., Chen, L., Grant, G., Cheng, Y.,Lawson, J.A., Assoian, R.K., Jones P.L., Fitzgerald G, Circulation 123(6): 631-639, 2011, PMID:21282500

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Antinatal administration of PPAR-gamma agonist RGZ prevents hyperoxia-induced rat lung injury.

Rehan, VK., Sakurai, R., Corral, J., Krebs, M., Ibe, B., Ihida-Stansbury, K., Torday, J.S., Am J Physiol Lung Cell Mol Physiol. 299(5): L672-680, 2010, PMID:20729387

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Lung vascular smooth muscle cell differentiation controlled by elastic matrix.

K. Ihida-Stansbury, S. Sanyal, C Navarro, P. Janmey, H. Sundararaghavan, J. Burdick, P.L. Jones, Mol Biol Cell 21 suppl(): , 2010

Lung SMC differentiation controlled by Prx1-dependent ECM property

K.Ihida-Stansbury, K.C. Kawabata, D.Patel, P Janmey, R Wells, P.L.Jones, Mol. Biol. Cell 20 (suppl)(): , 2009

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