PEOPLE

Malek Kamoun, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director, Clinical Immunology and Histocompatibility Laboratory
University of Pennsylvania Perelman School of Medicine

Contact InformationHospital of the University of Pennsylvania
7.020 Founders Pavilion
3400 Spruce St.
Philadelphia, PA 19104-4238
Office: (215) 614 1902
Fax: (215) 349-5090

Email: MALEKKAM@MAIL.MED.UPENN.EDU

Specialty Division

Laboratory Medicine

Research Expertise

Research Interests: HLA genes and molecules in clinical transplantation

Keywords: Human immunogenetics, HLA genes and molecules. Clinical Histocompatibility, clinical transplantation, autoimmunity.

Research Summary:

Dr. Kamoun's research interest is to define the extent and nature of HLA haplotype genetic diversity and to understand the biological relevance of amino acid polymorphism in HLA class I and class II molecules. Computational and biostatical methods are used to evaluate the significance of HLA amino acid polymorphism in clinical transplantation and autoimmunity.

Another interest is to better understand the impact of B cell alloresponse and anti-HLA antibodies on allograft outcomes in clinical transplantation including islet cell transplantation. Clinical trials are used to assess the effectiveness of B cell depleting agents on alloantibody levels and allograft survival in transplant recipients.
 

Clinical Expertise

Clinical laboratory immunology: Diagnostic tests used in the evaluation of autoimmune diseases, infectious diseases, and immune deficiencies.

Clinical histocompatibility testing: HLA genotyping and HLA antibody testing used for the evaluation of solid organ and allogeneic bone marrow/hematopoietic cell transplantion and donor selection.

Graduate Groups

Immunology

Education

Pre-Med Université de Strasbourg (France), 1970
MD Université de Pierre et Marie Curie (Paris, France), 1977
PhD (Immunogenetics), Université de Pierre et Marie Curie (Paris, France), 1977

Specialty Certification

American Board of Pathology; Clinical Pathology, 1981
American Board of Pathology; Immunopathology, 1984

Postgraduate Training

Intern, Immunohematology, Hospital Saint-Louis (Paris, France), 1975-1976
Fellowship, Immunogenetics, Hospital Saint-Louis (laboratory of Jean Dausset) (Paris, France), 1976-1977
Postdoctoral research fellowship in Immunogenetics, Sloan-Kettering Institute (laboratory of Dr. Bo Dupont) (New York, NY), 1977-1978
Associate, Medical Oncology, Fred A. Hutchinson Cancer Research Center (Seattle, WA), 1978-1980
Resident, Laboratory Medicine, University of Washington, 1978-1980
Fellowship, Hematopathology , Department of Laboratory Medicine, University Hospital (Seattle, WA), 1980-1981

Awards and Honors

Pasteur Valery Radot Fellowship (Paris, France), 1977
New Investigator Research Award, NCI, NIH, 1981
Special Fellow Award, Leukemia Society of America, 1984
Peter C. Nowell Teaching Award, University of Pennsylvania School of Medicine, 1992
Member, John Morgan Society (Philadelphia, PA), 1998
Co-Recipient, UPHS Patient Safety and Quality Award, 2003
Nominee, Outstanding Course Director Award, University of Pennsylvania School of Medicine, 2005
Co-Recipient, UPHS Patient Safety and Quality Award, 2005

Memberships and Professional Organizations

American Society for Clinical Histocompatibility and Immunogenetics (ASHI), 1983 - Present
Academy of Clinical Laboratory Physicians and Scientists (ACLPS), 1987 - Present
United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN), 2002 - Present
American Society of Transplant Physicians, 2002 - Present
National Kidney Registry, 2011 - Present
Federation of Clinical Immunology Societies, 2012 - Present
Immucor, 2014 - Present
American Society for Blood and Marrow Transplantation, 2015 - Present
Omixon, 2016 - Present
American Association of Pathologists, - Present
American Association of Immunologists, - Present
American Society of Clinical Pathologists, - Present
National Institutes of Health, - Present
Clinical Immunology Society, - Present
College of American Pathologist, - Present
The Food and Drug Administration (FDA) and The U.S. Department of Health and Human Services (HHS), - Present

Web Links


Selected Publications

HLA-A amino acid polymorphism and delayed kidney allograft function

Kamoun M, Holmes JH, Israni AK, Kearns JD, Teal V, Yang WP, Rosas SE, Joffe MM, Li H, Feldman HI, Proc Natl Acad Sci U S A 105(48): 18883-8, 2008, PMID:19033208

Read article

Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients

Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G, Transplantation 87(4): 557-62, 2009, PMID:19307794

Read article

A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery

Sutter JA, Kwan-Morley J, Dunham J, Du YZ, Kamoun M, Albert D, Eisenberg RA, Luning Prak ET, Clin Immunol 126(3): 282-90, 2008, PMID:18226586

Read article

Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation

Goral S, Prak EL, Kearns J, Bloom RD, Pierce E, Doyle A, Grossman R, Naji A, Kamoun M, Nephrol Dial Transplant 23(1): 390-2, 2008, PMID:17956891

Read article

Assessment of differences in HLA-A, -B, and -DRB1 allele mismatches among African-American and non-African-American recipients of deceased kidney transplants

Kamoun M, Israni AK, Joffe MM, Hoy T, Kearns J, Mange KC, Feldman D, Goodman N, Rosas SE, Abrams JD, Brayman KL, Feldman HI, Transplant Proc 39(1): 55-63, 2007, PMID:17275474

Read article

Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity

Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A, J Clin Endocrinol Metab 92(7): 2410-4, 2007, PMID:17488791

Read article

Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library

Monos D, Heliopoulos J, Argyris E, Cordopatis P, Zompra A, Kamoun M, J Mol Recognit 19(6): 535-41, 2006, PMID:16941565

Read article

Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution

Narula S, LaRosa DF, Kamoun M, Dalmau J, Levinson AI, Ann Allergy Asthma Immunol 98(5): 483-9, 2007, PMID:17521034

Read article

2008 ACLPS panel discussion on resident education in clinical pathology

Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR, Am J Clin Pathol 131(5): 618-22, 2009, PMID:19369619

Read article

Search PubMed for articles