PEOPLE

Maria P. Limberis, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information125 South 31st street, Suite 2011, TRL
Philadelphia, PA 19103
Office: 215-898-0226
Fax: 215-494-5444

Email: limberis@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Dr. Limberis is an expert in lung-directed gene transfer using viral-based vectors. She is developing AAV-based prophylactic vaccines for deadly airborne infectious diseases. She also investigates gene therapy for cystic fibrosis and studies the immunological implications of lung-directed gene therapy with an emphasis on cellular immune activation to therapeutic transgene products.

Itmat Expertise

Dr. Limberis is an expert in lung-directed gene transfer using viral-based vectors. She is developing AAV-based prophylactic vaccines for deadly airborne infectious diseases. She also investigates gene therapy for cystic fibrosis and studies the immunological implications of lung-directed gene therapy with an emphasis on cellular immune activation to therapeutic transgene products.

Education

B.Sc. Hons (Biochemistry), Liverpool John Moores University, United Kingdom, 1997
Ph.D. (Molecular Biology), University of Adelaide, Australia, 2003

Specialty Certification

Postgraduate Training

Post-doctoral Researcher, Gene therapy Therapy, University of Pennsylvania, 2003-2007

Awards and Honors

Award for Most meritorious LCGI student in the School of Biomolecular Sciences. Liverpool John Moores University. Liverpool-United Kingdom., 1996
Inaugural M.S. McLeod PhD Scholarship. University of Adelaide. Adelaide-Australia., 1998-2002
Centenary Medal for Contribution to the Australian Community through Scientific Research. Australian Government., 2001
Young Investigator of the Year. Thoracic Society of Australia and New Zealand. Adelaide-Australia., 2001
Greg Johnson Memorial Trust Student Prize. Australasian Gene Therapy Society. Sydney-Australia., 2001
Roche Pharmaceuticals Cystic Fibrosis Research Award. Thoracic Society of Australia and New Zealand. Brisbane-Australia., 2001
Travel Award, American Society of Gene Therapy., 2006
Travel Award, American Society of Gene Therapy., 2007
Travel Award, American Society of Gene Therapy., 2008

Memberships and Professional Organizations

Thoracic Society of Australia and New Zealand, 2000 - present
American Society of Gene and Cell Therapy, 2003 - Present
Hellenic Medical Society of Philadelphia, 2012 - Present

Web Links


Selected Publications

Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus.

Adam V.S., Crosariol M., Kumar S., Ge M.Q., Czack S.E., Roy S., Haczku A., Tretiakova A., Wilson J.M., Limberis M.P., Clinical and Vaccine Immunology 21(11): 1528-33, 2014

Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway

Nagai Y., Limberis M.P., Zhang H., Gene Therapy 21(2): 219-24, 2014

Self-Reactive CFTR T Cells in Humans: Implications for Gene Therapy

Calcedo R., Griesenbach U., Dorgan D.J., Soussi S., Boyd A.C., Davies J.C., Higgins T.E., Hyde S.C., Gill D.R., Innes J.A., Porteous D.J., Alton E.W., Wilson J.M., Limberis M.P., Human Gene Therapy Clinical Development 24(3): 108-115, 2013

Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza

Limberis M.P., Adam V.S., Wong G., Gren J., Kobasa D., Ross T.M., Kobinger G.P., Tretiakova A., Wilson J.M., Science Translational Medicine 5(187): 187ra72, 2013

Vectored expression of a broadly neutralizing antibody (FI6) in mouse airway provides partial protection against a new avian influenza A (H7N9) virus

Limberis M.P., Racine T., Kobasa D., Li Y., Gao G.F., Kobinger G., Wilson J.M., Clinical and Vaccine Immunology 12(20): 1836-7, 2013

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