PEOPLE

Maria P. Limberis, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information125 South 31st street, Suite 2011, TRL
Philadelphia, PA 19103
Office: 215-898-0226
Fax: 215-494-5444

Email: limberis@upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Dr. Limberis is an expert in lung-directed gene transfer using viral-based vectors. She is developing AAV-based prophylactic vaccines for deadly airborne infectious diseases. She also investigates gene therapy for cystic fibrosis and studies the immunological implications of lung-directed gene therapy with an emphasis on cellular immune activation to therapeutic transgene products.

Itmat Expertise

Dr. Limberis is an expert in lung-directed gene transfer using viral-based vectors. She is developing AAV-based prophylactic vaccines for deadly airborne infectious diseases. She also investigates gene therapy for cystic fibrosis and studies the immunological implications of lung-directed gene therapy with an emphasis on cellular immune activation to therapeutic transgene products.

Education

B.Sc. Hons (Biochemistry), Liverpool John Moores University, United Kingdom, 1997
Ph.D. (Molecular Biology), University of Adelaide, Australia, 2003

Specialty Certification

Postgraduate Training

Post-doctoral Researcher, Gene therapy Therapy, University of Pennsylvania, 2003-2007

Awards and Honors

Award for Most meritorious LCGI student in the School of Biomolecular Sciences. Liverpool John Moores University. Liverpool-United Kingdom., 1996
Inaugural M.S. McLeod PhD Scholarship. University of Adelaide. Adelaide-Australia., 1998-2002
Young Investigator of the Year. Thoracic Society of Australia and New Zealand. Adelaide-Australia., 2001
Roche Pharmaceuticals Cystic Fibrosis Research Award. Thoracic Society of Australia and New Zealand. Brisbane-Australia., 2001
Centenary Medal for Contribution to the Australian Community through Scientific Research. Australian Government., 2001
Greg Johnson Memorial Trust Student Prize. Australasian Gene Therapy Society. Sydney-Australia., 2001
Travel Award, American Society of Gene Therapy., 2006
Travel Award, American Society of Gene Therapy., 2007
Travel Award, American Society of Gene Therapy., 2008
Milton Graub Medical Recognition Award, Cystic Fibrosis Foundation, Delaware Valley Chapter., 2016

Memberships and Professional Organizations

Thoracic Society of Australia and New Zealand, 2000 - present
American Society of Gene and Cell Therapy, 2003 - Present
Hellenic Medical Society of Philadelphia, 2012 - Present

Web Links


Selected Publications

Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR+/- Rhesus Macaques.

Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM., Hum Gene Ther Clin Dev 28(1): 39-50, 2017

Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia.

Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM., Hum Gene Ther Clin Dev 28(1): 28-38, 2017

Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep.

Davey MG, Riley JS, Andrews A, Tyminski A, Limberis M, Pogoriler JE, Partridge E, Olive A, Hedrick HL, Flake AW, Peranteau WH., PLoS One 12(1): 0171132, 2017

Vector serotype screening for use in ovine perinatal lung gene therapy

McClain LE, Davey MG, Zoltick PW, Limberis MP, Flake AW, Peranteau WH, J Pediatr Surg 51(6): 879-84, 2016

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

Alton EW, Armstrong DK, Ashby D, Bayfield KJ, Bilton D, Bloomfield EV, Boyd AC, Brand J, Buchan R, Calcedo R, Carvelli P, Chan M, Cheng SH, Collie DD, Cunningham S, Davidson HE, Davies G, Davies JC, Davies LA, Dewar MH, Doherty A, Donovan J, Dwyer NS, Elgmati HI, Featherstone RF, Gavino J, Gea-Sorli S, Geddes DM, Gibson JS, Gill DR, Greening AP, Griesenbach U, Hansell DM, Harman K, Higgins TE, Hodges SL, Hyde SC, Hyndman L, Innes JA, Jacob J, Jones N, Keogh BF, Limberis MP, Lloyd-Evans P, Maclean AW, Manvell MC, McCormick D, McGovern M, McLachlan G, Meng C, Montero MA, Milligan H, Moyce LJ, Murray GD, Nicholson AG, Osadolor T, Parra-Leiton J, Porteous DJ, Pringle IA, Punch EK, Pytel KM, Quittner AL, Rivellini G, Saunders CJ, Scheule RK, Sheard S, Simmonds NJ, Smith K, Smith SN, Soussi N, Soussi S, Spearing EJ, Stevenson BJ, Sumner-Jones SG, Turkkila M, Ureta RP, Waller MD, Wasowicz MY, Wilson JM, Wolstenholme-Hogg P., Lancet Respir Med 3(9): 684-91, 2015

Adeno-Associated Virus Serotype 9-Expressed ZMapp in Mice Confers Protection Against Systemic and Airway-Acquired Ebola Virus Infection.

Limberis MP, Tretiakova A, Nambiar K, Wong G, Racine T, Crosariol M, Xiangguo Q, Kobinger G, Wilson JM., J Infect Dis 12(214): 1975-1979, 2016

Developmental Stage Determines the Efficiency of Gene Transfer to Muscle Satellite Cells by In Utero Delivery of Adeno-Associated Virus Vector Serotype 2/9

Stitelman D., Brazelton T., Bora A., Traas J., Joyeux L., Merianos D., Limberis M.P., Davey M.G., Flake A.W., Molecular Therapy - Methods and Clinical Development 1(14040): , 2014

Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza

Limberis M.P., Adam V.S., Wong G., Gren J., Kobasa D., Ross T.M., Kobinger G.P., Tretiakova A., Wilson J.M., Science Translational Medicine 5(187): 187ra72, 2013

Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus.

Adam V.S., Crosariol M., Kumar S., Ge M.Q., Czack S.E., Roy S., Haczku A., Tretiakova A., Wilson J.M., Limberis M.P., Clinical and Vaccine Immunology 21(11): 1528-33, 2014

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