PEOPLE

Jennifer J.D. Morrissette, PhD

Associate Professor of Clinical Pathology and Laboratory Medicine
Clinical Director, Center for Personalized Diagnostics
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
3020 Market Street, Suite 220
Philadelphia, PA 19104
Office: 215-898-5578
Fax: 215-898-9817

Email: jennifer.morrissette@uphs.upenn.edu

Specialty Division

Precision and Computational Diagnostics

Education

B.S. (Molecular Biology), State University of New York at Buffalo, 1986
Ph.D. (Molecular Genetics), State University of New York at Buffalo, 1992

Specialty Certification

American Board of Medical Genetics, Clinical Molecular Genetic Diagnostics, 2002
American Board of Medical Genetics, Clinical Cytogenetics, 2002
New York State Certificate of Qualification,
Cytogenetics and Molecular Genetic Diagnostics, 2004

Postgraduate Training

Postdoctoral Fellow, Molecular Genetics, Department of Pathology, Harvard Medical School, Boston MA, 1992-1997
Fellow in Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1998-2002

Awards and Honors

Mark Diamond Initiative Award, Department of Biological Sciences, State University of New York at Buffalo, 1990
Pathobiology of Cancer: The Edward A. Smuckler Memorial Workshop, Keystone Colorado, American Association of Cancer Research, 1992
NIH Intramural Research Training Award fellowship, 1992-1993
American Social Health Association/Burroughs Wellcome Fund Research Fellowship, 1994-1996
American Association of Cancer Research Fellowship, 1996-1997
General Clinical Research Center (GCRC). Children’s Hospital of Philadelphia, Investigator, 2001-2005
Foerderer Fund for Excellence, Molecular and Cytogenetic Analysis of Autism, 2003-2004
Peter C. Nowell Award in Pathology, University of Pennsylvania, 2013

Memberships and Professional Organizations

American Society Human Genetics, 1998 - Present
Philadelphia Genetics Group, 2004 - Present
American College of Medical Genetics, 2005 - Present
American Cytogenetics Conference, 2006 - Present
Association of Molecular Pathology, 2011 - Present

Web Links


Selected Publications

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S., Cell 173(6): 1439-1453, 2018, PMID:29856956

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In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C., Neuro Oncol., 2018, PMID:29617843

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ROS1 Rearrangement in a Case of Classic Biphasic Pulmonary Blastoma.

Jenkins TM, Morrissette JJD, Kucharczuk JC, Deshpande CG., Int J Surg Pathol 26(): , 2018, PMID:29295663

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JAK2 V617F-positive acute myeloid leukaemia (AML): a comparison between de novo AML and secondary AML transformed from an underlying myeloproliferative neoplasm. A study from the Bone Marrow Pathology Group.

Aynardi J, Manur R, Hess PR, Chekol S, Morrissette JJD, Babushok D, Hexner E, Rogers HJ, Hsi ED, Margolskee E, Orazi A, Hasserjian R, Bagg A., Br J Haematol., 2018, PMID:29767839

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Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.

Echevarría-Vargas IM, Reyes-Uribe PI, Guterres AN, Yin X, Kossenkov AV, Liu Q, Zhang G, Krepler C, Cheng C, Wei Z, Somasundaram R, Karakousis G, Xu W, Morrissette JJ, Lu Y, Mills GB, Sullivan RJ, Benchun M, Frederick DT, Boland G, Flaherty KT, Weeraratna AT, Herlyn M, Amaravadi R, Schuchter LM, Burd CE, Aplin AE, Xu X, Villanueva J., EMBO Mol Med., 2018, PMID:29650805

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Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ., Nature, 2018, PMID:29849141

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A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL, Loaiza-Bonilla A, Jensen CE, Randall M, Morrissette JJD, Shroff SG., J Gastrointest Oncol. 9(): , 2018, PMID:29564165

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Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.

Maxwell Kara N, Soucier-Ernst Danielle, Tahirovic Emin, Troxel Andrea B, Clark Candace, Feldman Michael, Colameco Christopher, Kakrecha Bijal, Langer Melissa, Lieberman David, Morrissette Jennifer J D, Paul Matt R, Pan Tien-Chi, Yee Stephanie, Shih Natalie, Carpenter Erica, Chodosh Lewis A, DeMichele Angela, Breast cancer research and treatment 164(): , 2017, PMID:28500398

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Most Myeloid Neoplasms With Deletion of Chromosome 16q Are Distinct From Acute Myeloid Leukemia With Inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study.

Rogers Heesun J, Hsi Eric D, Tang Guilin, Wang Sa A, Bueso-Ramos Carlos E, Lubin Daniel, Morrissette Jennifer J D, Bagg Adam, Cherukuri Durga P, George Tracy I, Peterson LoAnn, Liu Yen-Chun, Mathew Susan, Orazi Attilio, Hasserjian Robert P, American journal of clinical pathology 147(4): 411-419, 2017, PMID:28375434

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Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia.

Tasian Sarah K, Kenderian Saad S, Shen Feng, Ruella Marco, Shestova Olga, Kozlowski Miroslaw, Li Yong, Schrank-Hacker April, Morrissette Jennifer J D, Carroll Martin, June Carl H, Grupp Stephan A, Gill Saar, Blood 129(17): 2395-2407, 2017, PMID:28246194

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