PEOPLE

Jennifer J.D. Morrissette, PhD

Associate Professor of Clinical Pathology and Laboratory Medicine
Clinical Director, Center for Personalized Diagnostics
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
3020 Market Street, Suite 220
Philadelphia, PA 19104
Office: 215-898-5578
Fax: 215-898-9817

Email: jennifer.morrissette@uphs.upenn.edu

Specialty Division

Precision and Computational Diagnostics

Education

B.S. (Molecular Biology), State University of New York at Buffalo, 1986
Ph.D. (Molecular Genetics), State University of New York at Buffalo, 1992

Specialty Certification

American Board of Medical Genetics, Clinical Molecular Genetic Diagnostics, 2002
American Board of Medical Genetics, Clinical Cytogenetics, 2002
New York State Certificate of Qualification,
Cytogenetics and Molecular Genetic Diagnostics, 2004

Postgraduate Training

Postdoctoral Fellow, Molecular Genetics, Department of Pathology, Harvard Medical School, Boston MA, 1992-1997
Fellow in Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1998-2002

Awards and Honors

Mark Diamond Initiative Award, Department of Biological Sciences, State University of New York at Buffalo, 1990
NIH Intramural Research Training Award fellowship, 1992-1993
Pathobiology of Cancer: The Edward A. Smuckler Memorial Workshop, Keystone Colorado, American Association of Cancer Research, 1992
American Social Health Association/Burroughs Wellcome Fund Research Fellowship, 1994-1996
American Association of Cancer Research Fellowship, 1996-1997
General Clinical Research Center (GCRC). Children’s Hospital of Philadelphia, Investigator, 2001-2005
Foerderer Fund for Excellence, Molecular and Cytogenetic Analysis of Autism, 2003-2004
Peter C. Nowell Award in Pathology, University of Pennsylvania, 2013

Memberships and Professional Organizations

American Society Human Genetics, 1998 - Present
Philadelphia Genetics Group, 2004 - Present
American College of Medical Genetics, 2005 - Present
American Cytogenetics Conference, 2006 - Present
Association of Molecular Pathology, 2011 - Present

Web Links


Selected Publications

Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.

Maxwell Kara N, Soucier-Ernst Danielle, Tahirovic Emin, Troxel Andrea B, Clark Candace, Feldman Michael, Colameco Christopher, Kakrecha Bijal, Langer Melissa, Lieberman David, Morrissette Jennifer J D, Paul Matt R, Pan Tien-Chi, Yee Stephanie, Shih Natalie, Carpenter Erica, Chodosh Lewis A, DeMichele Angela, Breast cancer research and treatment 164(): , 2017, PMID:28500398

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Most Myeloid Neoplasms With Deletion of Chromosome 16q Are Distinct From Acute Myeloid Leukemia With Inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study.

Rogers Heesun J, Hsi Eric D, Tang Guilin, Wang Sa A, Bueso-Ramos Carlos E, Lubin Daniel, Morrissette Jennifer J D, Bagg Adam, Cherukuri Durga P, George Tracy I, Peterson LoAnn, Liu Yen-Chun, Mathew Susan, Orazi Attilio, Hasserjian Robert P, American journal of clinical pathology 147(4): 411-419, 2017, PMID:28375434

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Molecular and cytogenomic profiling of hepatic adenocarcinoma expressing inhibinA, a mimicker of neuroendocrine tumors: proposal to reclassify as "cholangioblastic variant of intrahepatic cholangiocarcinoma".

Braxton David R, Saxe Debra, Damjanov Nevena, Stashek Kristen, Shroff Stuti, Morrissette Jennifer D, Tondon Rashmi, Furth Emma E, Human pathology 62(): 232-241, 2017, PMID:28232156

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Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia.

Tasian Sarah K, Kenderian Saad S, Shen Feng, Ruella Marco, Shestova Olga, Kozlowski Miroslaw, Li Yong, Schrank-Hacker April, Morrissette Jennifer J D, Carroll Martin, June Carl H, Grupp Stephan A, Gill Saar, Blood 129(17): 2395-2407, 2017, PMID:28246194

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Optimized Depletion of Chimeric Antigen Receptor T-Cells in Murine Xenograft Models of Human Acute Myeloid Leukemia.

Tasian SK, Kenderian SS, Shen F, Ruella M, Shestova O, Kozlowski M, Li Y, Schrank-Hacker A, Morrissette JJ, Carroll M, June CH, Grupp SA, Gill S., Blood, 2017, PMID:28246194

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Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma.

Gangadhar TC, Savitch SL, Yee SS, Xu W, Huang AC, Harmon S, Lieberman DB, Soucier D, Fan R, Black TA, Morrissette JJD, Salathia N, Waters J, Zhang S, Toung J, van Hummelen P, Fan JB, Xu X, Amaravadi RK, Schuchter LM, Karakousis GC, Hwang WT, Carpenter EL., Pigment Cell Melanoma Res., 2017, PMID:28786531

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BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers.

Maxwell KN, Wubbenhorst B, Wenz BM, De Sloover D, Pluta J, Emery L, Barrett A, Kraya AA, Anastopoulos IN, Yu S, Jiang Y, Chen H, Zhang NR, Hackman N, D'Andrea K, Daber R, Morrissette JJD, Mitra N, Feldman M, Domchek SM, Nathanson KL., Nat Commun., 2017, PMID:28831036

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Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications.

Babushok DV, Duke JL, Xie HM, Stanley N, Atienza J, Perdigones N, Nicholas P, Ferriola D, Li Y, Huang H, Ye W, Morrissette JJD, Kearns J, Porter DL, Podsakoff GM, Eisenlohr LC, Biegel JA, Chou ST, Monos DS, Bessler M, Olson TS., Blood Adv. 1(): , 2017, PMID:28971166

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV., Sci Transl Med. 19(9): , 2017, PMID:28724573

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