PEOPLE

Irving Nachamkin, DrPH, MPH, D(ABMM), FAAM, FIDSA

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director, Division of Laboratory Medicine; Associate Director, Clinical Microbiology Laboratory; Laboratory Director, HUP, Radnor, and Rittenhouse
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Room 7-046 Founders Pavilion (Lab Administration)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: (215) 662-3435
Fax: (215) 349-5090

Email: Irving.Nachamkin@uphs.upenn.edu

Specialty Division

Laboratory Medicine

Research Expertise

I am a co-investigator in the CDC Prevention Epicenter at Penn and our lab is involved in several collaborative studies examining risk factors for development of antimicrobial resistant infections in hospitalized patients and in the community. I also have a special interest in Campylobacter and other gastrointestinal infections, with a focus on diagnostics, antibiotic resistance, and association of Campylobacter with Guillain-Barre Syndrome. Other areas of interest include diagnostic microbiology, molecular diagnostic microbiology, cost-effectiveness of laboratory testing.

Clinical Expertise

I am currently Director of the Division of Laboratory Medicine at the Hospital of the University of Pennsylvania. I also am Associate Director of the Clinical Microbiology Laboratory. My areas of expertise include most areas of clinical microbiology. I have particular interests in the diagnosis of gastrointestinal infections.

Education

B.Sc. (Medical Laboratory Science), University of Bridgeport, Bridgeport, CT, 1975
M.P.H. (Public Health Laboratory Practice), University of North Carolina at Chapel Hill, Chapel Hill, NC, 1978
Dr.P.H. (Public Health Microbiology), University of North Carolina at Chapel Hill, Chapel Hill, NC, 1980

Specialty Certification

MT (ASCP), American Society of Clinical Pathologists, 1975
Diplomate, American Board of Medical Microbiology, 1987

Postgraduate Training

Medical and Public Health Laboratory Microbiology, Dept. of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, 1980-1982
Penn Medicine Clinical Leadership Academy, Penn Medicine, 2010-2011

Awards and Honors

Becton Dickinson Pre-Doctoral Fellowship, University of North Carolina at Chapel Hill, 1977-1980
Professor (Hon.), Department of Neurology, Second Affiliated Hospital, Shijiazhuang, P.R. China, 1993
President's Award, New Jersey Public Health Association, 1995
Professor (Hon.) of Medical Sciences, Hebei Medical College, Shijiazhuang, P.R. China, 1995
Fellow, Infectious Diseases Society of America, 2000
Foundation for Microbiology Lecturer, American Society for Microbiology, Washington, DC, 2000-2002
Fellow, American Academy of Microbiology, 2000
Fellow, College of Physicians of Philadelphia, 2003
Elected Member, Council Policy Committee, American Society for Microbiology, 2005-2008
UPHS Quality Award, "Building a Culture of High-Value Care: Reducing Unnecessary Ordering of Inpatient Laboratory Tests", Sedrak MS, Murray D, Ziemba J, Myers J, Dine J, Tsypenyuk B, Nachamkin I, Mincarelli M, Danoski D, Brennan PJ, Hanson B, Berns J, 2015

Memberships and Professional Organizations

American Society of Clinical Pathologists, 1975 - Present
Eastern Pennsylvania Branch, American Society for Microbiology, 1982 - Present
American Society for Microbiology, 1982 - Present
Infectious Diseases Society of America, 1995 - Present
Food and Drug Administration, Microbiological Devices Review Panel, 1999 - Present
American Academy of Microbiology, 2000 - Present
Clinical Laboratory Standards Institute, 2004 - 2004
The Society for Healthcare Epidemiology of America, 2009 - Present
American Association for Clinical Chemistry, 2010 - Present
Association for Molecular Pathology, 2011 - Present

Web Links


Selected Publications

Factors associated with persistent colonisation with methicillin-resistant Staphylococcus aureus

Cluzet VC, Gerber JS, Nachamkin I, Coffin SE, Davis MF, Julian KG, Zaoutis TE, Metlay JP, Linkin DR, Tolomeo P, Wise JA, Bilder WB, Hu B, Lautenbach E, Epidemiology and Infection 145(): 1409-17, 2017

Isolation of Campylobacter species from stool samples using a filtration method: assessment from a U.S. based population

Nachamkin I, Nguyen P., J Clin Microbiol 55(): 2204-7, 2017

Effect of a Price Transparency Intervention in the Electronic Health Record on Clinician Ordering of Inpatient Laboratory Tests: The PRICE Randomized Clinical Trial

Sedrak MS, Myers JS, Small DS, Nachamkin I, Ziemba JB, Murray D, Kurtzman GW, Zhu J, Wang W, Mincarelli D, Danoski D, Wells BP, Berns JS, Brennan PJ, Hanson CW, Dine CJ, Patel MS, JAMA Intern Med, 2017

Epidemiology and Characteristics of Escherichia coli Sequence Type 131 (ST131) from Long-Term Care Facility Residents Colonized Intestinally with Fluoroquinolone-Resistant Escherichia coli

Han JH, Garrigan C, Johnson B, Nachamkin I Clabots C, Bilker WB, Santana E, Tolomeo P, Maslow J, Myers J, Carson L, Lautenbach E, Johnson JR, Diag Microbiol Infect Dis 87(3): 275-280, 2017

Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis

Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs B, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH for the CDC Prevention Epicenters Program, Diag Microbiol Infect Dis 85(): 109-15, 2016

Evaluation of a research use only luminex based assay for measurement of procalcitonin in serum samples

Garrigan C, Han J, Tolomeo P, Johnson KJ, Master SR, Lautenbach E and Nachamkin I, Am J Translation Research 8(): 4362-69, 2016

Multicenter evaluation of clinical diagnostic methods for detection and isolation of Campylobacter spp. from stool.

Fitzgerald C, Patrick M, Gonzalez A, Akin J, Polage C, Wymore K, Gillim-Ross L, Xavier K, Sadlowski J, Monahan J, Hurd S, Dahlberg S, Jerris R, Watson R, Santovenia M, Mitchell D, Harrison C, Tobin-D'Angelo M, DeMartino M, Pentella M, Leonard C, Razaq J, Jung C, Achong-Bowe R, Evans Y, Jain D, Juni B, Leano F, Robinson R, Smith S, Gittelman R, Garrigan C, Nachamkin I and Campylobacter Diagnostics Study Working Group, J Clin Microbiol 54(): 1209-1215, 2016

The Effect of Total Household Decolonization on Clearance of Colonization with Methicillin-Resistant Staphylococcus aureus

Cluzet VC, Gerber JS, Metlay JP, Nachamkin I, Zaoutis TE, Davis MF, Julian KG, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Biler WB, Han X, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Hu B, Fishman NO, Royer D, Lautenbach E., Infect Cont Hosp Epidemiol, 2016

Gastrointestinal Infections

Alby K., Nachamkin I., Microbiology Spectrum 4(3): doi:10.1128 /microbiolspec.DMIH2-0005-2015, 2016, PMID:27337464

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The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites

Misic A., David MF., Tyldsley AS, Hodkinson BP, Tolomeo P, Hu B., Nachamkin I, Lautenbach E, Morris DO., Grice EA., Microbiome 3(2): doi: 10.1186/s40168-014-0052-7, 2015

Campylobacter and Arcobacter

Fitzgerald, C. and I. Nachamkin, Chapter 56, Manual of Clinical Microbiology, 11th edition, 2015

Appropriateness of Expectorated Sputum Cultures in the Hospital Setting

Sloan CE, Bernard S, Nachamkin I., Diag Microbiol Infect Dis 83(1): 74-6, 2015, PMID:26032431

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Less is more: engaging residents and advanced practioners in a performance improvement project to reduce overutilization of daily labs at the Hospital of the University of Pennsylvania

Sedrak M., Ziemba J., Murray D., Tsypenyuk B., Mincarelli D., Danoski D, Nachamkin I., Dine J., Myers JS., 2015 ACGME Annual Educational Conference, San Diego, California, February 26 - March 1, 2015, 2015

Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa

Cluzet VC., Lautenbach E., Nachamkin I., Cary MS., Fishman NO., Morales K., Linkin DR., Infect Cont Hosp Epidemiol 36(4): 387-93, 2015

Duration of Colonization and Determinants of Earlier Clearance of Colonization with Methicillin-Resistant Staphylococcus aureus

Cluzet VC, Gerber JS, Nachamkin I, Metlay JP, Zaoutis TE, Davis MF, Julian KG, Royer D, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Bilker WB, Han X, Hu B, Fishman NO, Lautenbach E., Clin Infect Dis 60(10): 1489-96, 2015

Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficult infection

Bartsch SM, Umsheid CA, Nachamkin I, Hamilton K, Lee BY., Clin Microbiol Infect 21(1): 77.e1-9, 2015, PMID:25636938

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Use of a combination biomarker algorithm to identify medical intensive care unit patients with suspected sepsis at very low likelihood of bacterial infection

Han J., Nachamkin I., Coffin S., Gerber J., Fuchs B., Garrigan C., Han X., Bilker W., Wise J., Tolomeo P., Lautenbach E., Antimicrobial Agents Chemother 59(10): 6494-6500, 2015, PMID:26239984

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Risk factors for ambulatory urinary tract infections caused by high MIC-fluoroquinolone susceptible E. coli in women: results from a large case-control study

Rattanaumpawan P., Nachamkin I., Bilker WB., Roy JA., Metlay JP., Zaoutis TE., Lautenbach E., J Antimicrob Chemother 70(5): 1547-51, 2015, PMID:25630645

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Laboratory Developed Tests (LDTs)

Nachamkin I, Pepper Talk (blog), 2015

Prevalence and epidemiology of murpirocin resistance among those colonized with MRSA in the community.

Cluzet VC, Nachamkin I., Tolomeo P., Lautenbach E., ID Week (IDSA, SHEA), Oct 8-12, 2014, Philadelphia, 2014

Distribution of Campylobacter jejuni capsular types, 2007-2012, Philadelphia, PA

Garrigan C, Attela A, Poly F, Guerry P, Nachamkin I, Diag Microbiol Infect Dis 80(): 204-206, 2014

Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 (ST131) among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli

Han J., Johnston B., Nachamkin I., Tolomeo P., Bilker W., Mao X., Clabots C., Johnson J., Lautenbach E., Antimicrob Agents Chemother 58(): 7003-6, 2014

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