PEOPLE

Lili Wang, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information125 S. 31st Street
Suite 2000
Philadelphia, PA 19104
Office: 215-746-8929
Fax: 215-494-5443

Email: liliwang@mail.med.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Viral vectors, gene therapy, immune response, metabolic diseases and animal models

Itmat Expertise

gene transfer and gene therapy

Education

B.S. (Biology), Fudan University, Shanghai, China, 1986
PhD (Microbiology & Molecular Genetics), Rutgers University & Robert Wood Johnson Medical School, New Brunswick, New Jersey , 1996

Specialty Certification

Wharton Management Program, The Wharton School, University of Pennsylvania, 2002

Postgraduate Training

Graduate student, Genetics Institute, Fudan University, Shanghai, China, 1986-1990
Postdoctoral fellow, The Salk Institute, La Jolla, California, 1996-1999

Awards and Honors

Core Curriculum Fellowship, Rutgers University and Robert Wood Johnson Medical School, 1991-1992
Charles and Johanna Busch Summer Fellowship, Rutgers University, 1993-1993
NIH P30 Pilot Grant, 2005-2006

Memberships and Professional Organizations

American Society of Gene Therapy, 2000 - 2008
American Society of Gene and Cell Therapy, 2008 - Present

Web Links


Selected Publications

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

Yang Y*, Wang L*, Bell P, McMenamin D, He Z, White J, Yu H, Xu C, Morizono H, Musunuru K, Batshaw ML, Wilson JM., Nature Biotechnology 34(3): 334-338, 2016, PMID:26829317

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Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model

Bissig-Choisat B*, Wang L*, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HC, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD., Nature Communications 6(7339): , 2015

Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids

Wang L, Bell P, Somanathan S, Wang Q, He Z, Yu H, McMenamin D, Goode T, Calcedo R, Wilson JM., Molecular Therapy 23(12): 1877-1887, 2015

AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion and minimal MHCI upregulation on target cells.

Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM., Molecular Therapy 22(1): 28-41, 2014

Preclinical Evaluation of a Clinical Candidate AAV8 Vector for Ornithine Transcarbamylase (OTC) Deficiency Reveals Functional Enzyme from Each Persisting Vector Genome

Wang L, Morizono H, Lin J, Bell P, Jones D, McMenamin D, Yu H, Batshaw ML, and Wilson JM., Molecular Genetics and Metabolism 105(2): 203-211, 2012

Sustained Correction of OTC Deficiency in Spf ash Mice Using Optimized Self-complementary AAV2/8 Vectors

Wang L*, Wang H*, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, and Wilson JM. (Authors contributed equally), Gene Therapy 19(4): 404-10, 2012

AAV8-mediated Hepatic Gene Transfer in Infant Rhesus Monkeys (Macacca mulatta)

Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM, Molecular Therapy 19(11): 2012-2020, 2011

Impact of Pre-existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-associated Virus 8 Vectors

Wang L, Calcedo R, Bell P, Lin J, Grant R, Siegel DL, and Wilson JM., Human Gene Therapy 22(11): 1389-1401, 2011

Muscle-directed Gene Therapy for Hemophilia B with More Efficient and Less Immunogenic AAV Vectors

Wang L, Louboutin JP, Bell P, Greig J, Li Y, Wu D, and Wilson JM, Journal of Thrombosis and Haemostasis 9(10): 2009-19, 2011, PMID:21883883

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The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

Wang L, Calcedo R, Wang H, Bell P, Grant R, Vandenberghe LH, Sanmiguel J, Morizono H, Batshaw ML, and Wilson JM, Molecular Therapy 18(1): 126-134, 2010, PMID:19888196

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Systematic Evaluation of AAV Vectors for Liver-directed Gene Transfer in Murine Models

Wang L*, Wang H*, Bell P, McCarter RJ, He J, Calcedo R, Vandenberghe LH, Morizono H, Batshaw ML, and Wilson JM, Molecular Therapy 18(1): 118-125, 2010

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid.

Vandenberghe LH*, Wang L*, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, and Wilson JM, Nature Medicine 12(8): 967-71, 2006, PMID:16845388

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy.

Wang L, Calcedo R, Nichols TC, Bellinger DA, Dillow A, Verma IM, and Wilson JM, Blood 105(8): 3079-86, 2005, PMID:15637142

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