Gerald B. Wertheim, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA, 19104
Office: 267-970-5918
Fax: 215-590-1736


Specialty Division


Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis


BS (Chemistry), Yale University, New Haven CT, 1994
MD, PhD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
The Werner Bergmann Award in Chemistry, Yale University, 1994
summa cum laude, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
American Society of Hematology, 2015 - Present
Society of Hematopathology, 2015 - Present
College of American Pathologists, 2015 - Present
Children's Oncology Group, 2015 - Present

Selected Publications

Adaptive Reactivation of Signaling Pathways As a Novel Mechanism of Resistance to JAK Inhibitors in Ph-like ALL

Hurtz C, Tasian SK, Wertheim G, Astles R, Zebrowski, Perl AE, and Carroll M, 58th Annual American Society for Hematology Meeting and Exposition, San Diego, CA, 2016

Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma.

Yu H, Sotillo E, Harrington C, Wertheim G, Paessler M, Maude SL, Rheingold SR, Grupp SA, Thomas-Tikhonenko A, Pillai V., Am J Hematol, 2016, PMID:27779774

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BRAF kinase domain mutations in de novo acute myeloid leukemia with monocytic differentiation

Xu Y, Morrissette J, Wertheim GB, Bagg A, Leukemia and Lymphoma, 2016

Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: A case report

Lewen MO, Gresh R, Queenan M, Paessler M, Pillai V, Hexner E, Frank D, Bagg A, Aplenc R, Caywood E, Wertheim G, Biomarker Research, 2016, PMID:27453784

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High Incidence of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia (Ph-like ALL) in Older Adults with B-ALL

Tasian SK, Hurtz C, Wertheim GB, Bailey NG, Lim MS, Harvey RC, Chen I-M, Willman CL, RAstles R, Zebrowski, A, Reshmi SC, Li MM, Frey NV, Luger SM, Carroll M, and Perl AE, European Hematology Association 21st Congress, 2016

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein, J, Barrett DM, Weiss, SL, Fitzgerald JC, Berg, RA MD, Aplenc, R, Callahan C, Rheingold, SR, Zheng Z, Rose-John S, Nazimuddin F, Wertheim GB, Levine BL, June CH, Porter DL, Grupp SA, Cancer Discovery 6(6): 667-79, 2016, PMID:27076371

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A Clinical Measure of DNA Methylation Predicts Outcome in De Novo AML

Luskin M, Gimotty PA, Smith C, Loren A, Figueroa M, Harrison J, Sun Z, Tallman M, Paietta E, Litzow M, Melnick A, Levine RL, Fernandez H, Luger S, Carroll M, Master S, Wertheim G, JCI Insight 1(9): , 2016, PMID:27446991

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Marked eosinophilia masking B lymphoblastic leukemia.

Yu H, Wertheim GB, Shankar S, Paessler M, Aplenc R, Pillai V, Am J Hematol 9(5): 543-544, 2016, PMID:26662494

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Multi-Locus DNA Methylation Measured by xMELP Predicts Survival in Pediatric Patients with AML

Wertheim GB, Luskin M, Smith C, Zhou L, Harrison J, Figueroa M, Catchpoole D, Aplenc R, Tasian S, Carroll M, Master SR, United States and Candien Academy of Pathology 2016 Annual Meeting Seattle, WA, 2016