PEOPLE

Gerald B. Wertheim, MD, PhD

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736

Email: wertheimg@email.chop.edu

Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis

Education

BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
summa cum laude, Yale University, 1994
The Werner Bergmann Award in Chemistry, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
Society of Hematopathology, 2015 - Present
American Society of Hematology, 2015 - Present

Selected Publications

A Novel KMT2A-ARHGEF12 Fusion Gene Identified in a High-Grade B-cell Lymphoma

Jung HS, Lin F, Wolpaw A, Reilly AF, Margolskee E, Luo M, Wertheim GB, Li MM, Cancer Genetics, 2020, PMID:32805689

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Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL

Hurtz C, Wertheim GB, Loftus JP, Blumenthal D, Lehman A, Li Y, Bagashev A, Manning B, Cummins KD, Burkhardt JK, Perl AE, Carroll M, Tasian SK, The Journal of Clinical Investigation 130(7): 3637-3653, 2020, PMID:32191635

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Evolution of Histomorphologic, Cytogenetic, and Genetic Abnormalities in an Untreated Patient With MIRAGE Syndrome

Rentas S, Pillai V, Wertheim GB, Akgumus GT, Nichols KE, Deardorff MA, Conlin LK, Li MM, Olson TS, Luo M, Cancer Genetics 245(): 42-48, 2020, PMID:32619790

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Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Cai Z, Aguilera F, Ramdas B, Daulatabad SV, Srivastava R, Kotzin JJ, Carroll M, Wertheim G, Williams A, Janga SC, Zhang C, Henao-Mejia J, Kapur R., Cell Reports 31(12): 107816, 2020, PMID:32579941

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Characterization of Plasmacytoid Dendritic Cells, Microbial Sequences, and Identification of a Candidate Public T-cell Clone in Kikuchi-Fujimoto Lymphadenitis

Nelson ND, Meng W, Rosenfeld A, Bullman S, Pedamullu CS, Nomburg JL, Wertheim GBW, Paessler, ME, Pinkus GS, Hornick JL, Meyerson ML, Prak EL, Pillai V, United States and Canadian Academy of Pathology 2020 Los Angeles, California, 2020

Increased mTOR activation in idiopathic multicentric Castleman disease.

Arenas DJ, Floess K, Kobrin D, Pai RL, Srkalovic MB, Tamakloe MA, Rasheed R, Ziglar J, Khor J, Parente SAT, Pierson SK, Martinez D, Wertheim GB, Kambayashi T, Baur J, Teachey DT, Fajgenbaum DC, Blood 135(19): 1673‐1684, 2020, PMID:32206779

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Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling.

Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA, Blood Advances 4(6): 1145-1158, 2020, PMID:32208490

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CD19-Negative B-ALL Relapses after CAR T Cell Therapy are Associated with a Hypermutator Phenotype

Yang G, Faude S, Paessler ME, Wertheim GBW, Pillai V, United States and Canadian Academy of Pathology 2020 Los Angeles, California, 2020

Absolute Lymphocyte Count Kinetics Correlates with Response and Toxicity in CAR T Therapy

Faude S, Pillai V, Paessler ME, Wertheim GBW, United States and Canadian Academy of Pathology 2020 Los Angeles, California, 2020

Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study

Oberley MJ, Raikar SS, Wertheim GB, Malvar J, Sposto R,Rabin KR, Punia JN, Seif AE, Cahen VC, Schore RJ, Luca DC, Guinipero T, Woods WG, O'Gorman MRG, Orgel E, Leukemia, 2020, PMID:32060402

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