Gerald B. Wertheim, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736


Specialty Division


Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis


BS (Chemistry), Yale University, New Haven CT, 1994
MD, PhD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
summa cum laude, Yale University, 1994
The Werner Bergmann Award in Chemistry, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
American Society of Hematology, 2015 - Present
Society of Hematopathology, 2015 - Present
College of American Pathologists, 2015 - Present
Children's Oncology Group, 2015 - Present

Selected Publications

Severe Mucha-Habermann-like Ulceronecrotic Skin Disease in T-cell ALL Responsive to Basiliximab and Stem Cell Transplant

Grenstein LAV, Coughlin CC, Flynn AT, Pillai V, Boos MD, Wertheim GW, Treat JR, Teachey DT, Pediatric Dermatology 34(5): e265-e270, 2017, PMID:28884915

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NPM1 for MRD? Droplet Like It's Hot!

Wertheim GBW, Bagg A, J Mol Diagn 4(): 498-501, 2017, PMID:28645444

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Cytosine deaminase APOBEC3A sensitizes leukemia cells to inhibition of the DNA replication checkpoint

Green AM, Budagyan K, Hayer KE, Reed MA, Savani MR, Wertheim GB, Weitzman MD, Cancer Res, 2017, PMID:28655787

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Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.

Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, Le L, Jambhekar M, Raman P, Hayer KE, Wertheim G, Speck NA, Tong W, Viatour P, J Exp Med 214(7): 1901-1912, 2017, PMID:20160719

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Immunohistochemistry Identifies AML Subtypes with Distinct Genetics and Prognosis

Wertheim G, Pillai V, Sargent R, Paessler M, Lewen M, Li J, Master S, Carroll M, Luskin M, United States and Canadian Academy of Pathology 2017 Annual Meeting, San Antonio, Texas, 2017

Validation of a Clinical Assay of Multi-Locus DNA Methylation for Prognosis of Newly Diagnosed AML

DiNardo CD, Luskin MR, Carroll M, Smith C, Harrison J, Pierce S, Kornblau S, Konopleva M, Kadia T, Kantarjian H, Wertheim G, Master SR, Am J Hematol 92(2): E14-E15, 2017, PMID:27804182

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Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma.

Yu H, Sotillo E, Harrington C, Wertheim G, Paessler M, Maude SL, Rheingold SR, Grupp SA, Thomas-Tikhonenko A, Pillai V., Am J Hematol 92(1): E11-E13, 2017, PMID:27779774

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High incidence of philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) in older adults with B-ALL.

Tasian SK, Hurtz C, Wertheim GB, Bailey NG, Lim MS, Harvey RC, Chen IM, Willman CL, Astles R, Zebrowski A, Reshmi SC, Li MM, Frey NV, Luger SM, Carroll M, Perl AE., Leukemia, 2017, PMID:27932787

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Cytochemical Staining

Paessler ME, Helfrich M, Wertheim GB, Acute Myeloid Leukemia Methods and Protocols, 2017, PMID:28735478

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