PEOPLE

Megan S. Lim, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Director, Hematopathology

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
609 Stellar-Chance
422 Curie Blvd.
Philadelphia, PA 19104
Tel.: 215-662-6550


Email: Megan.Lim@uphs.upenn.edu

Specialty Division

Precision and Computational Diagnostics, Hematopathology

Itmat Expertise

hematologic cancer
molecular pathogenesis
genomic analysis
mass spectrometry driven proteomics

Education

BS (Cell and Microbiology), University of Calgary, 1983
MS (Biochemistry, Cell Regulation Group, Department of Medical Biochemistry, Faculty of Medicine), University of Calgary, 1988
MD (Medicine), University of Calgary, 1988
PhD (Molecular Oncology), University of Calgary joint with National Cancer Institute, National Institute of Health, 1999

Specialty Certification

Licentiate of Medical Council of Canada (LMCC), 1988
Fellow, Royal College of Physicians and Surgeons of Canada (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Hematology), 1999
Diplomate of American Board of Pathology (Molecular Genetic Pathology), 2003

Postgraduate Training

Residency in Anatomic Pathology, University of Calgary, 1988-1993
Chief Resident, Pathology Training Program, Foothills Hospital (Calgary, Alberta), 1991-1991
Research Fellowship, Cancer Research Group, Faculty of Medicine, University of Calgary, 1993-1995
Fellowship, Hematopathology, Lab of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 1995-1998
Mid-Career Women Faculty Professional Development Seminar, Association of American Medical Colleges, 2003-2003
Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health, Boston, MA, 2012-2012

Awards and Honors

Louise McKinney Scholarship for Outstanding Academic Achievement, University of Calgary, 1982
Faculty of Science Dean’s List, University of Calgary (Calgary, Alberta), 1982
Alberta Heritage Foundation for Medical Research Summer Studentship, 1983
Alberta Heritage Foundation for Medical Research Studentship, 1983-1985
Alberta Heritage Foundation for Medical Research Part-Time Studentship (while in MD program), 1985-1987
Nominated by Medical Research Council of Canada for the Royal Society of Canada’s Women in Scholarship Alice Wilson Award, 1993
Fee Scholarship Award, Faculty of Graduate Studies, University of Calgary, 1994-1997
National Institutes of Health Fogarty Visiting Fellowship, 1996-1998
Junior Scientist Award, Canadian Association of Pathology, 2000
Young Investigator Award, Children’s Oncology Group, 2002
Translational Research Award, Children’s Oncology Group, 2004
Best Doctors of America, 2005-2014

Memberships and Professional Organizations

Canadian Medical Association, 1985 - 1993
Canadian Association of Pathologists, 1988 - Present
Canadian Medical Protective Association, 1993 - 2000
Royal College of Physicians and Surgeons of Canada, 1993 - Present
American Association for Cancer Research, 1994 - Present
United States and Canadian Academy of Pathology, 1995 - Present
Society for Hematopathology, 1995 - Present
American Society of Hematology, 1995 - Present
American Association for the Advancement of Science, 1997 - 1999
College of Physicians and Surgeons of Ontario, 1998 - 2003
Association for Molecular Pathology, 1998 - Present
European Society of Hematopathology, 1998 - Present
Canadian Hematology Society, 1999 - 2001
American Society for Investigative Pathology, 2002 - Present
Children’s Oncology Group, 2002 - Present
American Biologic Resources and Facilities, 2005 - Present
American Society of Mass Spectrometry, 2006 - 2006
A. J. French Society, 2007 - Present
Michigan Society of Pathologists, 2007 - Present
American Society for Clinical Pathology, 2008 - Present
3rd International Symposium on Non-Hodgkin Lymphoma of Childhood and Young Adolescents, Frankfurt, 2008 - 2009
1st International Symposium on Childhood, Adolescent and Young Adult Hodgkin Lymphoma, Arlington, VA, 2010 - 2011
4rd International Symposium on Non-Hodgkin Lymphoma of Childhood and Young Adolescents, New York City, NY, 2011 - 2012
InterLymph Consortium: International Lymphoma Epidemiology Consortium, 2012 - 2012
Second International Symposium on Childhood, Adolescent and Young Adult Hodgkin Lymphoma, Berlin, Germany, 2012 - 2014
College of American Pathologists, 2014 - 2014
United States Cutaneous Lymphoma Consortium, 2014 - 2014
Pluto Society, 2015 - Present

Web Links


Selected Publications

Novel ALK fusion in a case of Anaplastic Large Cell Lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex.

Palacios G, Shaw T, Li Y, Singh RK, Valentine M, Sandlund JT, Lim MS, Mullighan CG, Leventaki V., Leukemia Epub ahead of print(): , 2016, PMID:27840423

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T-cell receptor signaling activates an ITK/NF-kB/GATA-3 axis in T-cell lymphomas facilitating resistance to chemotherapy.

Wang T, Lu Y, Polk A, Chowdhurry P, Zamalloa CM, Fujiwara H, Suemori K, Beyersdorf N, Hristov AC, Lim MS, Bailey NG, Wilcox RA., Clin Cancer Res, 2016, PMID:27780854

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NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma.

Murga-Zamalloa CA, Mondoza-Reinoso V, Sahasrabuddhe AA, Rolland DCM, Hwang SR, McDonnell SR, Scialis AP, Wilcox RA, Bashur V, Elenitoba-Johnson KSJ, Lim MS., Oncogene 10(1038): , 2016, PMID:27694894

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PDL structural rearrangements in B-cell NHL.

Lim Megan S, Blood 128(9): 1159-61, 2016, PMID:27587863

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Targetable gene fusions in T-cell lymphoma.

Lim Megan S, Blood 128(9): 1161-2, 2016, PMID:27587864

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Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma.

Udager Aaron M, McHugh Jonathan B, Betz Bryan L, Montone Kathleen T, Livolsi Virginia A, Seethala Raja R, Yakirevich Evgeny, Iwenofu O Hans, Perez-Ordonez Bayardo, DuRoss Kathleen E, Weigelin Helmut C, Lim Megan S, Elenitoba-Johnson Kojo Sj, Brown Noah A, The Journal of pathology 239(4): 394-8, 2016, PMID:27234382

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Precision Medicine for Diffuse Large B-cell Lymphoma.

Lim Megan S, Elenitoba-Johnson Kojo S J, Clinical cancer research : an official journal of the American Association for Cancer Research 22(12): 2829-31, 2016, PMID:26988247

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Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells.

Park Jin-Young, Lim Man-Sup, Kim Song-In, Lee Hee Jae, Kim Sung-Soo, Kwon Yong-Soo, Chun Wanjoo, Biomolecules & therapeutics, 2016, PMID:27257013

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Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.

Pillai Vinodh, Tallarico Michael, Bishop Michael R, Lim Megan S, British journal of haematology 173(4): 573-81, 2016, PMID:26992145

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API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis.

Rosebeck Shaun, Lim Megan S, Elenitoba-Johnson Kojo S J, McAllister-Lucas Linda M, Lucas Peter C, World journal of biological chemistry 7(1): 128-37, 2016, PMID:26981201

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