Megan S. Lim, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Director, Hematopathology

Contact InformationDepartment of Pathology and Laboratory Medicine
Stellar Chance Office Suite 609C
422 Curie Blvd.

Philadelphia, PA, 19104
Office: 215-898-4719
Fax: 215-898-9969


Specialty Division


Itmat Expertise

hematologic cancer
molecular pathogenesis
genomic analysis
mass spectrometry driven proteomics


BS (Cell and Microbiology), University of Calgary, 1983
MS (Biochemistry, Cell Regulation Group, Department of Medical Biochemistry, Faculty of Medicine), University of Calgary, 1985
MD (Medicine), University of Calgary, 1988
PhD (Molecular Oncology), University of Calgary joint with National Cancer Institute, National Institute of Health, 1999

Specialty Certification

Licentiate of Medical Council of Canada (LMCC), 1988
Diplomate of American Board of Pathology (Anatomic Pathology), 1993
Fellow, Royal College of Physicians and Surgeons of Canada (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Hematology), 1999
Diplomate of American Board of Pathology (Molecular Genetic Pathology), 2003

Postgraduate Training

Residency in Anatomic Pathology, University of Calgary (Calgary, Alberta), 1988-1993
Chief Resident, Pathology Training Program, Foothills Hospital (Calgary, Alberta), 1991-1991
Research Fellowship, Cancer Research Group, Faculty of Medicine, University of Calgary (Calgary, Alberta), 1993-1995
Fellowship, Hematopathology, Lab of Pathology, National Cancer Institute, National Institutes of Health, (Bethesda, MD), 1995-1998
Mid-Career Women Faculty Professional Development Seminar, Association of American Medical Colleges (Washington, DC), 2003-2003
Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health (Boston, MA), 2012-2012

Awards and Honors

Louise McKinney Scholarship for Outstanding Academic Achievement, University of Calgary, 1982
Faculty of Science Dean’s List, University of Calgary, 1982
Alberta Heritage Foundation for Medical Research Studentship, 1983-1985
Alberta Heritage Foundation for Medical Research Summer Studentship, 1983
Alberta Heritage Foundation for Medical Research Part-Time Studentship (while in MD program), 1985-1987
Nominated by Medical Research Council of Canada for the Royal Society of Canada’s Women in Scholarship Alice Wilson Award, 1993
Fee Scholarship Award, Faculty of Graduate Studies, University of Calgary, 1994-1997
National Institutes of Health Fogarty Visiting Fellowship, 1996-1998
Junior Scientist Award, Canadian Association of Pathology, 2000
Young Investigator Award, Children’s Oncology Group, 2002
Translational Research Award, Children’s Oncology Group, 2004
Best Doctors of America, 2005-2014
Pluto Society, 2015

Memberships and Professional Organizations

Canadian Medical Association, 1985 - 1993
Canadian Association of Pathologists, 1988 - Present
Canadian Medical Protective Association, 1993 - 2000
Royal College of Physicians and Surgeons of Canada, 1993 - Present
American Association for Cancer Research, 1994 - Present
American Society of Hematology, 1995 - Present
Society for Hematopathology/European Association for Haemotopathology, 1995 - Present
United States and Canadian Academy of Pathology, 1996 - Present
American Association for the Advancement of Science, 1997 - 1999
Association for Molecular Pathology, 1998 - Present
European Society of Hematopathology, 1998 - 2016
College of Physicians and Surgeons of Ontario, 1998 - 2003
Canadian Hematology Society, 1999 - 2001
Children’s Oncology Group, 2002 - Present
American Society for Investigative Pathology, 2002 - Present
American Biologic Resources and Facilities, 2005 - Present
American Society of Mass Spectrometry, 2006 - 2006
A. J. French Society, 2007 - Present
Michigan Society of Pathologists, 2007 - Present
American Society for Clinical Pathology, 2008 - Present
St. Baldrick's Foundation, 2011 - Present
Lymphoma Research Foundation, 2011 - Present
United States Cutaneous Lymphoma Consortium, 2014 - 2014
College of American Pathologists, 2014 - Present
Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Peer Review Cancer Research Program (PRCRP) - Lymphoma (LYM), 2016 - Present
University of Michigan, 2016 - 2016
Ontario Genomics; Grant Review - Genome Canada, Large-Scale Applied Research Project on Genomics in Precision Health., 2017 - 2017
National Science Center, Poland, 2017 - 2017
NIH Lymphoma and Leukemia Molecular Profiling Project Grant, 2019 - 2024

Web Links

Selected Publications

Immunophenotypic, cytotoxic, proteomic and genomic, characterization of human cord blood vs. peripheral blood CD56Dlm NK cells.

Shereck E. Day NS, Awasthi A, Ayello J, Chu Y, McGuinn C, van de Ven C, Lim MS, Cairo MS., Innate Immun., 2019, PMID:31068047

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Advancing biomarker development through convergent engagement. Summary Report of the 2nd International Danube Symposium on biomarker development, molecular imaging and applied diagnostics.

Lim MS, Beyer T, Babayan A, Bergmann M, Brehme M, Buyx A, Czernin J, Egger G, Elenitoba-Johnson KSJ, Gückel B, Jačan A, Haslacher H, Hicks RJ, Kenner L, Langanke M, Mitterhauser M, Pichler BJ, Salih HR, Schibli R, Schultz S, Simecek J, Simon J, Soares MO, Stelzl U, Wadsak W, Zatloukal K, Zeitlinger M, and Hacker M., Molecular Imaging and Biology., 2019, PMID:31049831

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Mass spectrometry and proteomics in hematology.

Rollan DCM, Lim MS, Elenitoba-Johnson KSJ., Seminars in Hematology 56(1): 52-57, 2019, PMID:30573045

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PMBCL: a molecular diagnosis?

Lim MS, Blood 132(22): 2319-2320, 2018, PMID:30498068

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Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation, in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model.

Chu Y, Lee S, Shah T, Yin C, Barth M, Miles RR, Ayello J, Harrison L, Van de Ven C, Galandry P, Goldman SC, Lim MS, Hermiston M, McAllister-Luca LM, Giulino-Roth L, Perkins SL, Cairo MS., Oncoimmunology 8(1): , 2018, PMID:30546948

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International, evidence-based consensus treatment guidelines for the management of idiopathic multicentric Castleman disease.

Fajgenbaum DC, Oksendhendler E, Casper C, Uldrick, T, Kurzrock R, Yoshizaki K, Nasta S, Rossi JF, Wong R, Simpson D, Sato Y, Terriou L, Ferrero S, Zinzani PL, Hoffman C, Goodman A, Krymskaya V, Elenitoba-Johnson KSJ, Lim MS, Chadburn A, Penmaraju N, Leitch H, Jaffe ES, Jayanthan R, Chandrasakan S, Lechowicz MJ, Ruth J, Greenway A, Stone K, Shilling D, Mukherjee S, Partridge HL, Pierson SK, Streetly M, Schey S, Munshi N, Ide M, Srkalovic G, Fossa A, Dispenzieri A, Voorhees P, van Rhee F., Blood, 2018, PMID:30181172

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Novel Insights into the pathogenesis of T-cell Lymphomas

Van Arnam JS, Lim MS, Elenitoba-Johnson KSJ, Blood 11(): , 2018, PMID:29666117

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Pre-clinical activity of targeting the PI3K/Akt/m TOR pathway in Burkitt lymphoma

Bhatti M, Ippolito T, Mavis C, Gu J, Cairo MS, Lim MS, Hernandez-Ilizaliturri F, Barth MJ, Oncotarget 9(31): 21820-21830, 2018, PMID:29774105

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Treatment options for paediatric anaplastic large cell lymphoma (ALCL): current standard and beyond.

Prokoph N, Larose H, Lim MS, Burke GAA, Turner SD., Cancers (Basel) 10(4): , 2018, PMID:29601554

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