Megan S. Lim, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Director, Hematopathology

Contact InformationDepartment of Pathology and Laboratory Medicine
Stellar Chance Office Suite 609C
422 Curie Blvd.

Philadelphia, PA, 19104
Office: 215-898-4719
Fax: 215-898-9969


Specialty Division


Itmat Expertise

hematologic cancer
molecular pathogenesis
genomic analysis
mass spectrometry driven proteomics


BS (Cell and Microbiology), University of Calgary, 1983
MS (Biochemistry, Cell Regulation Group, Department of Medical Biochemistry, Faculty of Medicine), University of Calgary, 1985
MD (Medicine), University of Calgary, 1988
PhD (Molecular Oncology), University of Calgary joint with National Cancer Institute, National Institute of Health, 1999

Specialty Certification

Licentiate of Medical Council of Canada (LMCC), 1988
Diplomate of American Board of Pathology (Anatomic Pathology), 1993
Fellow, Royal College of Physicians and Surgeons of Canada (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Hematology), 1999
Diplomate of American Board of Pathology (Molecular Genetic Pathology), 2003

Postgraduate Training

Residency in Anatomic Pathology, University of Calgary (Calgary, Alberta), 1988-1993
Chief Resident, Pathology Training Program, Foothills Hospital (Calgary, Alberta), 1991-1991
Research Fellowship, Cancer Research Group, Faculty of Medicine, University of Calgary (Calgary, Alberta), 1993-1995
Fellowship, Hematopathology, Lab of Pathology, National Cancer Institute, National Institutes of Health, (Bethesda, MD), 1995-1998
Mid-Career Women Faculty Professional Development Seminar, Association of American Medical Colleges (Washington, DC), 2003-2003
Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health (Boston, MA), 2012-2012

Awards and Honors

Faculty of Science Dean’s List, University of Calgary, 1982
Louise McKinney Scholarship for Outstanding Academic Achievement, University of Calgary, 1982
Alberta Heritage Foundation for Medical Research Summer Studentship, 1983
Alberta Heritage Foundation for Medical Research Studentship, 1983-1985
Alberta Heritage Foundation for Medical Research Part-Time Studentship (while in MD program), 1985-1987
Nominated by Medical Research Council of Canada for the Royal Society of Canada’s Women in Scholarship Alice Wilson Award, 1993
Fee Scholarship Award, Faculty of Graduate Studies, University of Calgary, 1994-1997
National Institutes of Health Fogarty Visiting Fellowship, 1996-1998
Junior Scientist Award, Canadian Association of Pathology, 2000
Young Investigator Award, Children’s Oncology Group, 2002
Translational Research Award, Children’s Oncology Group, 2004
Best Doctors of America, 2005-2014
Pluto Society, 2015

Memberships and Professional Organizations

Canadian Medical Association, 1985 - 1993
Canadian Association of Pathologists, 1988 - Present
Canadian Medical Protective Association, 1993 - 2000
Royal College of Physicians and Surgeons of Canada, 1993 - Present
American Association for Cancer Research, 1994 - Present
United States and Canadian Academy of Pathology, 1995 - Present
Society for Hematopathology/European Association for Haemotopathology, 1995 - Present
American Society of Hematology, 1995 - Present
American Association for the Advancement of Science, 1997 - 1999
Association for Molecular Pathology, 1998 - Present
European Society of Hematopathology, 1998 - 2016
College of Physicians and Surgeons of Ontario, 1998 - 2003
Canadian Hematology Society, 1999 - 2001
Children’s Oncology Group, 2002 - Present
American Society for Investigative Pathology, 2002 - Present
American Biologic Resources and Facilities, 2005 - Present
American Society of Mass Spectrometry, 2006 - 2006
Michigan Society of Pathologists, 2007 - Present
A. J. French Society, 2007 - Present
American Society for Clinical Pathology, 2008 - Present
Lymphoma Research Foundation, 2011 - Present
St. Baldrick's Foundation, 2011 - Present
United States Cutaneous Lymphoma Consortium, 2014 - 2014
College of American Pathologists, 2014 - Present
University of Michigan, 2016 - 2016
Department of Defense Congressionally Directed Medical Research Programs (CDMRP), 2016 - Present
Ontario Genomics; Grant Review - Genome Canada, Large-Scale Applied Research Project on Genomics in Precision Health., 2017 - 2017
National Science Center, Poland, 2017 - 2017
NIH Lymphoma and Leukemia Molecular Profiling Project Grant, 2019 - 2024

Web Links

Selected Publications

International, Evidence-based Consensus Treatment Guidelines for the Management of Idiopathic Multicentric Castleman Disease.

Fajgenbaum DC, Oksendhendler E, Casper C, Uldrick, T, Kurzrock R, Yoshizaki K, Nasta S, Rossi JF, Wong R, Simpson D, Sato Y, Terriou L, Ferrero S, Zinzani PL, Hoffman C, Goodman A, Krymskaya V, Elenitoba-Johnson KSJ, Lim MS, Chadburn A, Penmaraju N, Leitch H, Jaffe ES, Jayanthan R, Chandrasakan S, Lechowicz MJ, Ruth J, Greenway A, Stone K, Shilling D, Mukherjee S, Partridge HL, Pierson SK, Streetly M, Schey S, Munshi N, Ide M, Srkalovic G, Fossa A, Dispenzieri A, Voorhees P, van Rhee F., Blood, 2018, PMID:30181172

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Pre-clinical activity of targeting the PI3K/Akt/m TOR pathway in Burkitt lymphoma

Bhatti M, Ippolito T, Mavis C, Gu J, Cairo MS, Lim MS, Hernandez-Ilizaliturri F, Barth MJ, Oncotarget 9(31): 21820-21830, 2018, PMID:29774105

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Novel Insights into the pathogenesis of T-cell Lymphomas

Van Arnam JS, Lim MS, Elenitoba-Johnson KSJ, Blood 11(): , 2018, PMID:29666117

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Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond.

Prokoph N, Larose H, Lim MS, Burke GAA, Turner SD., Cancers (Basel) 10(4): , 2018, PMID:29601554

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Pathology of Castleman Disease

Wu D, Lim MS, Jaffe ES., Hematol Oncol Clin North Am 32(1): 37-52, 2018, PMID:29157618

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Human Papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas

Udager AM, McHugh JB, Goudsmit CM, Weigelin HC, Lim MS, Elenitoba-Johnson KSJ, Betz BL, Carey TE, Brown NA., Annals of Oncol., 2017, PMID:29145573

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New Insights into Lymphoma Pathogenesis

Elenitoba-Johnson KSJ, Lim MS, Annu Rev Pathol, 2017, PMID:29140757

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Targeting ALK with Cizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study.

Mosse YP, Voss SD, Lim MS, Rolland DCM, Minard CG, Fox E, Adamson PC, Wilner K, Blaney SM, Weigel B., J Clin Oncol 35(28): 3215-3221, 2017, PMID:28787259

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Poster presentation "Characterization of Histone Post-Translational Modifications of Cutaneous T-cell Lymphomas"

Önder Ö, Rolland DCM, Yuan Z-F, Garcia BA, Lim MS and Elenitoba-Johnson KSJ, 65thAmerican Society for Mass Spectrometry Conference on Mass Spectrometry & Allied Topics, 2017