Zheng Cai, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact Information252 John Morgan Building
36th St and Hamilton Walk
Philadelphia, PA 19104
Immunobiology and Experimental Pathology
-protein production(E.Coli, Insect, Mammalian)
-protein structure determination (NMR/Crystallization)
-protein/protein, protein/ligand interaction, ITC, SPR, co-crytallization
-structure-based drug design and development.
-Kinase inhibitors, small molecule drugs
-antibody mimetics, peptide drugs
-Targeted therapies for ErbB and related receptors.
-Breast cancer, lung cancer, Colon Cancer
B.S. (Biology), University of Sci. and Tech. of China , 1997
Ph.D. (Biochemistry and Molecular Biology), University of Sci. and Tech. of China , 2004
Postdoctoral Researcher, Department of Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, 2005-2010
Awards and Honors
Memberships and Professional Organizations
American Association for Cancer Research - AACR, 2010 - 2011
Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, Greene MI*, Nature Communications, 2015
Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT).
Cai Z, Yarovoi SV, Zhu Z, Rauova L, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, and Greene MI*., 56th ASH annual meeting, 2014
Multi-crystal native SAD analysis at 6 keV.
Liu Q, Guo Y, Chang Y, Cai Z, Assur Z, Mancia F, Greene MI, Hendrickson WA., Acta Crystallogr D Biol Crystallogr 70(Pt 10): 2544-57, 2014
scFv-based "grababody" as a general strategy to improve recruitment of immune effector cells to antibody-targeted tumors.
Cai Z, Fu T, Nagai Y, Lam L, Yee M, Zhu Z and Zhang H, Cancer Research 73(8): 2619-27, 2013
Runkle EA, Zhang H, Cai Z, Zhu Z, Karger BL, Wu SL, O'Rourke DM, Zhou Z, Wang Q, Greene MI, Experimental and molecular pathology 93(3): 324-33, 2012, PMID:23022358
Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI, Cell reports 1(6): 665-75, 2012, PMID:22813742
Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin.
Berezov A, Cai Z, Freudenberg J A, Zhang H, Cheng X, Thompson T, Murali R, Greene M I, Wang Q, Oncogene 31(15): 1938-48, 2012, PMID:21892210
Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
Zhou Z*, Du X*, Cai Z*, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R, Wu SL, Karger BL, Greene MI, Wang Q. (* co-first author), The Journal of biological chemistry 287(8): 5317-26, 2012, PMID:22170055
Cai Z, Zhang H, Liu J, Berezov A, Murali R, Wang Q, Greene MI., Seminars in cell & developmental biology 21(9): 961-6, 2010, PMID:20850557
Epigenetic Regulation of Autoimmune Diseases through Deacetylase Inhibition. THE EPIGENETICS OF AUTOIMMUNE DISEASE,Chapter 21
Li B*, Shen Y, Zhou Z, Song X, Bembas K, Zhao XY, Cai Z, Berezov A, Saouaf SJ, Zhang HT, Wang Q and Greene MI*., John Wiley & Sons, Inc, 2009