MacLean Nasrallah, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationHospital of the University of Pennsylvania
3400 Spruce St.
Philadelphia, PA 19104

Specialty Division


Research Expertise

brain development
mouse models
in utero electroporation in mouse models
molecular biology

Itmat Expertise

Brain tumors
Neuropathology and Genetic/molecular pathology advances

Clinical Expertise

molecular pathology of neuropathology


AB (Mathematics), Harvard University, 1997
PhD (Neuroscience), University of Pennsylvania, 2010
MD University of Pennsylvania, 2012

Specialty Certification

Anatomic Pathology and Neuropathology, American Board of Pathology, 2016

Postgraduate Training

Resident in Anatomic Pathology, Hospital of the University of Pennsylvania, 2012-2014
Fellow in Neuropathology, Hospital of the University of Pennsylvania, 2014-2016

Awards and Honors

ASCP Academic Excellence and Achievement in Pathology award, 2012

Memberships and Professional Organizations

Association for Pathology Informatics, 2013 - Present
American Society for Clinical Pathology, 2013 - Present
United States and Canadian Academy of Pathology, 2013 - Present
Association for Molecular Pathology, 2015 - Present
American Association of Neuropathologists, 2015 - Present

Web Links

Selected Publications

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV, Science Translational Medicine, 2017

19-Year-Old Male with Headaches and a Possible Seizure.

Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M, Brain Pathology, 2017

Perilesional Hyperintensity on T1-Weighted Images in Intra-Axial Brain Masses other than Cavernous Malformations.

Nabavizadeh S Ali, Pechersky Dasha, Schmitt J Eric, Nasrallah MacLean, Wolf Ronald, Loevner Laurie, Mamourian Alexander C, Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2017, PMID:28098958

Read article

Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla.

Verma Gaurav, Mohan Suyash, Nasrallah MacLean P, Brem Steven, Lee John Y K, Chawla Sanjeev, Wang Sumei, Nagarajan Rajakumar, Thomas M Albert, Poptani Harish, Journal of translational medicine 14(1): 274, 2016, PMID:27659543

Read article

Intramedullary Recurrence of a Thoracic Meningioma-Presentation of an Unusual Case and Review of the Literature.

Piazza Matthew A, Ramayya Ashwin G, Geiger Geoffrey A, Alonso-Basanta Michelle, Nasrallah MacLean P, Welch William C, Ozturk Ali K, World neurosurgery 92(): 588.e17-21, 2016, PMID:26852709

Read article

Developmental interneuron subtype deficits after targeted loss of Arx.

Marsh Eric D, Nasrallah MacLean Pancoast, Walsh Caroline, Murray Kaitlin A, Nicole Sunnen C, McCoy Almedia, Golden Jeffrey A, BMC neuroscience 17(1): 35, 2016, PMID:27287386

Read article

Images in Endocrine Pathology: Parasitic Nodule of Thyroid in Neck of Patient with Family History of Papillary Thyroid Carcinoma.

Nasrallah MacLean P, Pramick Michelle R, Baloch Zubair W, Endocrine pathology 26(3): 273-5, 2015, PMID:25217334

Read article

Fine-needle aspiration of superficial myxoid neurofibroma in the region of the breast.

Nasrallah MacLean P, Nasrallah Ilya M, Yu Gordon H, Diagnostic cytopathology 43(5): 427-31, 2015, PMID:25722038

Read article

Parathyroid carcinoma in the setting of tertiaryhyperparathyroidism after renal transplant.

Nasrallah MacLean P, Fraker Douglas L, LiVolsi Virginia A, Endocrine pathology 25(4): 433-5, 2014, PMID:25284121

Read article

Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression.

Nasrallah MacLean Pancoast, Cho Ginam, Simonet Jacqueline C, Putt Mary E, Kitamura Kunio, Golden Jeffrey A, Human molecular genetics 21(5): 1090-8, 2012, PMID:22108177

Read article