PEOPLE

Craig H. Bassing, PhD

Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationChildren's Hospital of Philadelphia
4054 Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-0311
Fax: 267-426-2791

Education

B.A. (Biology), The Johns Hopkins University, 1992
Ph.D. (Biology), Duke University, 1997

Postgraduate Training

Research Fellow in Molecular Immunology, Irvington Institute for Immunological Research, 1997-2000
Research Fellow in Molecular Immunology, CBR Institute for Biomedical Research, 1997-2000
Research Fellow in Genetics, Harvard Medical School, 1997-2002
Research Fellow in Medicine, Boston Children's Hospital, 1997-2002
Research Associate in Molecular Immunology, Howard Hughes Medical Institute, 2000-2003
Research Fellow in Cancer Genetics , Lymphoma Research Foundation, 2003-2005

Awards and Honors

Alpha Epsilon Delta Honor Society, The Johns Hopkins University Chapter, 1990
Howard Hughes Medical Institute, Summer Fellow, 1991
Phi Beta Kappa Honor Society, The Johns Hopkins University Chapter, 1991
University Honors, The Johns Hopkins University, 1992
Golden Key Honor Society, The Johns Hopkins University Chapter, 1992
Departmental Honors (Biology), The Johns Hopkins University, 1992
National Science Foundation Pre-Doctoral Fellow Award, 1992-1995
Irvington Institute for Immunological Research Fellow Award, 1997-2000
Lymphoma Research Foundation Fellow Award, 2003-2005
W.W. Smith Charitable Trust Award, 2005-2007
Pew Scholar in the Biomedical Sciences, 2005-2009
Foerderer-Murray Award, 2005-2006
American Cancer Society Institutional Research Award, 2005-2006
American Cancer Society Institutional Research Award, 2006-2007
American Cancer Society Institutional Research Award, 2008
Lassin Family Cancer Research Award at the Abramson Cancer Center of the University School of Medicine, 2008-2009
Michael S. Brown New Investigator Research Award, University of Pennsylvania School of Medicine, 2009
Pathology and Laboratory Medicine Chair Award of the Children's Hospital of Philadelphia, 2010
Leukemia and Lymphoma Society Scholar Award, 2010-2015
Simon Flexner Award of the Pathology and Laboratory Medicine Department, Perelman School of Medicine of the University of Pennsylvania, 2017

Memberships and Professional Organizations

American Association for the Advancement of Science, 1992 - present
American Association of Immunologists, 2005 - present
Abramson Cancer Center of the Perelman School of Medicine at the University of Pennsylvania, 2005 - present
National Cancer Institute, 2006 - 2006
Cerimon Pharmaceuticals, Inc., 2006 - 2008
Irvington Institute for Immunological Research, 2006 - 2006
Wellcome Trust, 2008 - 2008
UK Cancer Research Project, 2008 - 2008
American Association for Cancer Research, 2008 - present
Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 OBT-A (58) R Meeting, National Institutes of Health, 2009 - 2009
New York Academy of Sciences, 2009 - present
Center for Childhood Cancer Research, Children's Hospital of Philadelphia Research Institute, 2009 - present
Ad Hoc Reviewer, Cellular and Molecular Immunology B Study Section, Section of Scientific Review, National Institutes of Health, 2009 - 2009
NIH Study Section ZRG1 IMM-D (02) M - Member Conflict: Myeloid cell Development and Immunoglobulin Repertoire, National Institutes of Health, 2010 - 2010
Israel Science Foundation Grant Program, 2010 - 2010
The Henry Kunkel Society, 2010 - 2012
Austrian Academy of Sciences, Austrian Programme for Advanced Research and Technology, 2010 - 2010
Member, Faculty of 1000, Leukocyte Development Section in the Immunology Faculty, 2012 - present
Special Emphasis Panel/Scientific Review Group 2014/05 ZRG1 IMM-M (80) S Meeting, National Institutes of Health (Reviewer), 2014 - 2014
Member, Board of Scientific Counselors, Division of Intramural Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 2014 - 2014
Ad Hoc Reviewer, Cellular and Molecular Immunology B Study Section, Section of Scientific Review, National Institutes of Health, 2016 - 2016

Selected Publications

BTG2-PRMT1 protein complexes antagonize pre-B cell proliferation to promote B cell development

Glendon Wu and Craig H. Bassing, Celular and Molecular Immunology In Press(): , 2017

Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks

Fisher, M.R., Rivera-Reyes, A., Bloch, N.B., Schatz, D.G., Bassing, C.H., The Journal of Immunology 198(): 2943-2956, 2017

The ESCRT protein CHMP5 escorts ab T cells through positive selection

Glendon Wu and Craig H. Bassing, Cellular and Molecular Immunology Epub ahead of print(): , 2017

V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity.

Arya R and Bassing CH., Trends Genetics S0168-9525(): 30071-9., 2017

Genomic Alterations of Non-Coding Regions Underlie Human Cancer: Lessons from T-ALL

Rivera-Reyes, A, Hayer, K.E.,. and Bassing, C.H., Trends in Molecular Medicine 12(): 1035-1046, 2016

RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals

Bednarski, J.J., Pandey, R., Schulte, E., White, L.S., Chen, B.R., Sandoval, G.J., Kohyama, M., Haldar, M., Nickless, A., Trott, A., Cheng, G., Murphy, K.M., Bassing, C.H., Payton, J.E., Sleckman, B.P., The Journal of Experimental Medicine 2(): 209-23., 2016

Lymphocyte Lineage- and Developmental Stage-Specific Downregulation of Cyclin D3 in Response to DNA Double Strand Breaks

DeMicco, A., Reich, T., Arya, R., Rivera-Reyes, A., Fisher, M.R., and Bassing C.H., Cell Cycle 21(): :2882-2894, 2016

RAG-mediated DNA double-strand breaks activate a cel type-specific checkpoint to inhibit pre-B cell receptor signals

Bednarski, J.J., Pandey, R., Schulte, W., White, L.S., Chen, B.R., Sandoval, G.J., Kohyama, M., Haldar, M., Nickless, A., Trott, A., Cheng, G., Murphy, K.M., Bassing, C.H., Payton, J.E., and Sleckman, B.P., The Journal of Experimental Medicine 213(): 209-223, 2016

Inhibition of precursor B cell malignancy progression by toll-like receptor ligand-induced immune responses

Fidanza, M., Seif, A.E., DeMicco, A., Rolf, N., Jo, S., Yin, B., Li, Y., Barrett, D.M., Duque-Afonso, J., Cleary, M.L., Bassing, C.H., Grupp, S.A., Reid, G.S., Leukemia 10(): 10):2116-2119, 2016, PMID:27220664

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B cell-intrinsic expression of the HuR RNA-binding protein is required for the T cell-dependent immune response in vivo

DeMicco, A., Naradikian, M.S., Sindhava, V.J., Yoon, J-H., Gorospe, M., Wertheim, G.B., Cancro, M.P., and Bassing, C.H., The Journal of Immunology 195(): 3449-3462, 2015