Douglas B. Cines, MD

Professor of Medicine, Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Director, Coagulation Laboratory

Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012


Specialty Division

Laboratory Medicine, Immunobiology and Experimental Pathology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.


A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972

Specialty Certification

American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980

Postgraduate Training

Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
Academy of Clinical Laboratory Physicians and Scientists, 1990
American Association of University Pathologists, 1995
BACH Award, International Society on Thrombosis and Haemostasis (ISTH), 2017

Memberships and Professional Organizations

American Society of Hematology, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Federation for Clinical Research, 1980 - Present
American Society of Hematology, 1986 - 1991
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
American Society of Hematology, 1992 - 1993
Philadelphia Hematology Society, 1992 - 2000
American Society of Hematology, 1999 - 2002
International Society on Thrombosis and Haemostasis., 2000 - 2006
Federation of Clinical Immunology Societies, 2002 - Present
Platelet Disorder Support Association, 2004 - Present
US Food and Drug Administration, 2004 - 2005
American Association of Immunologists, 2004 - Present
International Society of Thrombosis and Haemostasis., 2007 - 2012
American Society of Hematology, 2010 - 2012
US Department of Justice, Vaccine Division, 2011 - 2012
American Society of Hematology, 2012 - Present
American Society of Hematology, 2015 - Present
American Society of Hematology, 2015 - Present

Web Links

Selected Publications

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B, Translational stroke research, 2018, PMID:29476447

Read article

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R, Blood advances 2(3): 165-176, 2018, PMID:29365311

Read article

Targeting Plasminogen Activator Inhibitor 1 in Tetracycline-Induced Pleural Injury in Rabbits

Florova, G., Azghani, A., Karandashova, S., Schaefer, C., Yarovoi S.V., Declerck, P.J., Cines, D.B., Idell, S. and Komissarov, A.A., Am J Physiol Lung Cell Molec Physiol 314(1): L54-L68, 2018, PMID:28860148

Read article

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R., Blood Advances 1(18): 1452-65, 2017

Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT).

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L., ISTH. Berlin, Germany, 2017

Thrombocytopenia in pregnancy

Cines D.B., Levine L.D., Blood, 2017, PMID:28637667

Read article

Pathogenic antibodies in heparin-induced thrombocytopenia (HIT) activate monocytes and induce profound membrane remodeling.

Andrianova, I., Hayes, V., Litvinov, R., Cines, D.B., Poncz, M., Weisel, J.W. and Rauova, L., ISTH. Berlin, Germany, 2017

Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia?

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M., ISTH. Berlin, Germany, 2017

Platelet-specific chemokines contribute to the pathogenesis of acute lung injury.

Bdeir, Kh., Mei, J., Gollomp, K., Stasiak, M., Zhou, G., Cines, D.B., Worthein, G.S., Poncz, M. and Kowalska, M.A., American Journal of Respiratory Cell and Molecular Biology 56(2): 261-270, 2017, PMID:27755915

Read article

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M., The Journal of Clinical Investigation 127(3): 1090-1098, 2017, PMID:28218620

Read article