PEOPLE

Peter F. Davies, PhD, ScD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815

Email: pfd@pennmedicine.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics, computational fluid dynamics, endocardial endothelium and 4D-flow MRI.

CVI Expertise

Research Interests
Cell and molecular biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular phenotyping, membrane biophysics, to biomechanics, computational fluid dynamics, genomics, epigenomics, 4-D flow MRI and endocardial endothelial phenotypes.

Other Expertise

Biophysics; Lipid metabolism

Itmat Expertise

Dr. Davies is interested in how temporal and spatial hemodynamics regulates cell and molecular phenotyping of endothelial cell physiology and pathology.

Graduate Groups

Cell and Molecular Biology
Pharmacology

Education

B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.)), University of Newcastle-upon-Tyne, 1969
M.Sc. (Biochemistry), University of Victoria, B.C., Canada, 1972
Ph.D. (Experimental Pathology), University of Cambridge, 1975
Sc.D. (Higher Doctorate), University of Cambridge, 2015

Specialty Certification

Postgraduate Training

Postdoctoral Research (Exptl. Path), Cambridge University, UK, 1975-1976
Senior Research Fellow (Cellular Pathology), University of Washington, Seattle, USA, 1977-1978

Awards and Honors

International Exchange Scholar, University of Wageningen, Netherlands, 1968-1968
UK Science Research Council Cooperative Award in Pure Science 1972-75, Cambridge University, 1972-1975
NIH grant awards 1978 onwards. (RO1; PPG; SCOR; R21, Training Grants); AHA Grants in Aid; HHMI Interfaces Award, 1978-present
Member (4 years), NHLBI Research Review Committee B, 1986-1990
Awardee, Louis Block Fund for Basic Research and Advanced Study, University of Chicago, 1988
Chairman, AHA Vascular Wall Biology Research Study Committee, 1991-1999
Chairman, Gordon Research Conference on Atherosclerosis, 1991
Director (5 years), NIH Cardiovascular Pathophysiology and Biochemistry
Training Grant, The University of Chicago, 1991-1996
NIH MERIT Award (10 years of funding), 1993-2003
The Vaishnav Lecture, Catholic University, Washington DC, 1994
Spudich Lecture, American Heart Association National Research Committee, Dallas, 1995
Vice-Chair, AHA National Research Committee, Dallas, 1995-1997
M.A.(honoris causa), University of Pennsylvania, 1996
SpaceLabs Medical Lecture, American Society Hypertension in Pregnancy, Vancouver, 1996
Elected Fellow, American Institute for Medical and Biological Engineering (FAIMBE), Washington DC, 1996
Guest Editor J. Biomechanics, 1996
Chairman, AHA National Research Committee, Dallas, 1997-1999
1997 CARIM Medal and Lecturer (Cardiovascular Research Medal), University of Maastricht, Netherlands, 1997
Distinguished Lecturer in Biomechanical Engineering, Stanford University, 1998
Inaugural Lecturer, A.C. Suhren-Whitaker Lecture Series in Tissue Engineering, Tulane University, 1998
Director, NIH (NHLBI) Multidisciplinary Training Program in Cardiovascular Biology, University of Pennsylvania, 2000-2020
2nd Benjamin Zweifach Memorial Lecturer in Biomedical Engineering, City College of New York, 2000
Special Recognition Award, American Heart Association ATVB Council, Dallas, 2000
Member (3 years), Smart Medical Systems Team, National Space Biomedical Research Institute (NSBRI) NASA, 2001-2004
Elected Fellow of the American Heart Association (FAHA), 2001
Keynote Speaker, British Heart Foundation Conference on Biorheology, Imperial College of Science Technology and Medicine, London, 2001
Member, US-Russia Cardiology Delegation (NHLBI), Moscow, 2001
Guest Editor, Circulation Research, 2002
Endothelome Lecture, Japan Physiome Project, Sapporo, Japan, 2003
Keynote Address, International Biofluid Symposium, California Institute of Technology (CalTech), Pasadena, 2003
Paulette Shirey Pritchett Endowed Lecture in Pathology, Univ. of Alabama, 2003
2004 Senior Research Scientist Award (Scientist of the Year)
American Heart Association (AHA) Mid-Atlantic Region, 2004
Bio-X Lecture, Frontiers in Interdisciplinary Biosciences. Stanford University, 2004
Endowed Chair: Robinette Foundation Professor of Cardiovascular Medicine (10 years), 2005-2015
Chair, NIH (NHLBI) Working Group on Computational Biology of the Vessel Wall, 2005
Distinguished Lecturer in Bioengineering, University of California at Berkeley, 2006
Director, HHMI-NIBIB Interfaces Award (3 years), Training Program in Biomedical Imaging and Informational Science, 2006-2009
Elected to Board of Directors, National Space Biomedical Research Institute (NASA), 2007-2017
2007 Haust Distinguished Lecturer in Cell and Molecular Pathology, Queens University, Canada, 2007
Member (3 years), NIH Study Section, R21 Innovation Grants, NHLBI, 2008-2011
Member, NIH Study Section; K99/R00 Pathway to Independence Awards, NHLBI, 2009-2014
Invited Visiting Fellow (2 month Sabbatical)
Isaac Newton Institute for Mathematical Sciences, Cambridge University, UK, 2009
Co-Director, NIH (NIBIB) Integrated Graduate Training Program in Biomedical Imaging and Informational Sciences., 2009-2016
Member, HHMI Review Panel
Med into Grad Training Program,
Howard Hughes Medical Institute (HHMI), 2009-2012
Member ad hoc, NIH Study Section Hypertension and Microcirculation, NHLBI, 2009-2011
Appointed to College of CSR Reviewers, NIH, 2010
Invited State-of-the Art. AXA Inaugural Chair Symposium. Ecole Polytechnique, Paris, 2010
Special Dean's Award, University of Pennsylvania School of Medicine. Medical Educational Leadership (for HHMI-NIH Interfaces Program), 2010
Member, HHMI Review Committee
International Fellowship Program, 2011-2013
Biomedical Postdoctoral Programs Distinguished Mentorship Award, University of Pennsylvania School of Medicine, 2011
10th Ramzi Cotran Memorial Lecturer, Harvard Medical School, 2011
Plenary Speaker, British Atherosclerosis Society, Queens College, Cambridge University, 2011
Keynote Speaker, British Heart Foundation Center of Excellence, Imperial College, London, 2012
Distinguished Keynote Lecture, Frontiers in Cardiovascular Biology, European Society of Cardiology, London, 2012
Dean's Distinguished Lecturer, College of Medicine, University of Kentucky, Lexington, 2012
Chair, Scientific Advisory Board, British Heart Foundation Center of Excellence, Imperial College London, 2012
2013 Netherlands Heart Foundation Lecturer, Erasmus University, Rotterdam, 2013
Keynote Speaker, McGill University Systems Biology Symposium. Montreal, 2013
2013 B.Lowell Langille Memorial Lecture, University of Toronto, 2013
Standing Member, Mentored Transition to Independence Review Committee,
National Heart Lung & Blood Institute, NIH., 2014-2018
Guest Co-Editor, In-Focus Review series. Arteriosclerosis Thrombosis & Vascular Biology (ATVB), 2014-2015
2014 Hugh Sinclair Memorial Lecturer, British Atherosclerosis Society, Queens College, University of Cambridge, 2014
Keynote Speaker, 6th Biennial Heart Valve Biology & Tissue Engineering Meeting, Royal Society, London, 2014
Elected Distinguished Fellow American Association for the Advancement of Science (AAAS), 2016
Sc.D. Doctor of Science, University of Cambridge.
Higher Doctorate awarded for Distinguished Research in Science. [Earned doctorate by examination], 2016
Keynote Speaker, 26th Scientific Meeting of the International Society of Hypertension, Seoul S Korea, 2016-2016
Keynote Speaker, 2nd Joint Meeting European Vascular Biology Organization/Euro Microcirculation Society. Geneva, Switzerland, 2017
2018 Richard Skalak Memorial Lecturer in Biomedical Engineering, University of California at San Diego, 2018

Memberships and Professional Organizations

Biochemical Society, London, 1974 - 1996
NHLBI Special Study Sections and Special Emphasis Panels, 1978 - Present
American Society for Cell Biology (ASCB), 1979 - 1998
American Society of the Advancement of Science (AAAS), 1979 - Present
Arteriosclerosis Council, American Heart Assocation (AHA), 1979 - Present
American Association of Pathologists (AAP)/American Society for Investigative Pathology (ASIP), 1980 - Present
National Science Foundation: NSF proposals, 1980 - 1999
AAAS Annual Meeting Science Innovation Subcommittee, 1982 - Present
NHLBI Research Review Committee B, 1986 - 1990
External Advisory Committee, Vascular Smooth Muscle Program Project, University of Virginia, 1987 - 1990
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, Budget Committee, 1988 - Present
NASA: Microgravity Sciences Applications Division, Space Station Freedom, Biotechnology Program Johnson Space Center, 1989 - 1989
AHA: Subgroup D, Fellowship Review Committee, 1989 - Present
AHA: Nominating and Awards Committee, 1989 - Present
AHA: Lipoprotein, Lipid Metabolism and Epidemiology Research Study Committee (National), 1989 - Present
AHA: Inter-Council Working Group on Vascular Biology, 1989 - Present
AHA: SACC Task Force on New Research Initiatives, 1989 - Present
AHA: Arteriosclerosis, Thrombosis & Vascular Biology (ATVB) Council, Program Committee, 1989 - Present
AHA: National Research Committee, 1989 - Present
AHA: Fellowship Awards Symposium, 1989 - Present
AHA: Vascular Wall Biology Research Study Committee, 1989 - Present
AHA: Research Program Evaluation Committee (RPEC), 1989 - Present
AHA: Scientific Advisory Council, 1989 - Present
AHA-Metropolitan Chicago Affiliate, Grant Review Committee, 1990 - 1992
Advisory Board, International Vascular Biology Meeting 2000, Geneva, Switzerland, 1990 - 2000
Cardiovascular Review Committee, Tobacco Related Diseases Research Program for the State of California, 1990 - 1993
American Physiology Society, 1991 - 2010
Veterans Administration Hospitals. Project grant reviews, 1991 - 1996
NHLBI Program Projects and SCORs, 1992 - 1996
US-Israel Binational Research Grant Program, 1992 - 1998
NASA: Gravitational Influences on Mechano Transduction, Life Sciences Division, Washington, 1993 - 1993
North American Vascular Biology Organization (NAVBO): Executive Council, 1994 - 2018
The Wellcome Trust (UK). Wellcome Senior Research Fellowships, 1994 - 1996
American Institute for Medical and Biological Engineering (AIMBE), 1996 - Present
Bioengineering Graduate Group, University of Pennsylvania, 1996 - Present
Scientific Advisory Committee, Whitaker Foundation, 1998 - 1999
Council for Medical and Health Research of the Netherlands Organization for Scientific Research, 1998 - 1998
NASA: Cardiovascular Alterations Workshop, National Space Biomedical Research Institute, Houston, 1999 - 1999
John Morgan Society, 1999 - Present
Science and Technology Commission, University of Virginia, 1999 - 2000
Biophysical Society, 1999 - 2003
Smart Medical Systems Team, National Space Biomedical Research Institute (NSBRI) NASA, 1999 - 2003
Florence Medical, Tel Aviv, Israel, 1999 - 2000
Georgia Tech–Emory University, Department of Biomedical Engineering, 1999 - 2003
British Heart Foundation, London, 2000 - Present
“Proatherosclerotic Genes”, NHLBI RFA Task Force (NIH), 2000 - 2000
Hong Kong Government Medical Research Program, 2000 - 2000
Interenational Advisory Board, Japanese Physiome Project, 2000 - 2000
Genomics and Computational Biology Graduate Group, University of Pennsylvania, 2001 - 2011
NIH Delegation, US-Russia Symposium on Basic Research in Cardiovascular and Pulmonary Diseases, Moscow, 2001, 2001 - 2001
NIH Cardiovascular Sciences IRG Study Section Boundary Team, 2001 - 2001
Scientific Advisory Board, Clinigenetics, Nimes, France, 2001 - 2002
Council on Basic Cardiovascular Sciences (AHA), 2001 - Present
Hypertension Council (AHA), 2001 - Present
Science Foundation Ireland (SFI) Medical Research Program, 2003 - 2006
Royal Society of New Zealand Marsden Fund, 2010 - 2010
Division of Biology and Medicine, Swiss National Science Foundation, Geneva, 2010 - 2013
HHMI International Student Dissertation Research Fellowship Program, 2010 - 2012
John D. and Catherine T. MacArthur Foundation,, 2012 - 2012
European Research Area Network on Cardiovascular Diseases (ERA-CVD, 2016 - 2017
Advanced Health Technologies Panel, Research Excellence Program, Ontario Research Fund, Toronto, Canada, 2018 - Present

Web Links


Selected Publications

In: LabStudio: Design Research Between Architecture & Biology.

Davies P.F., Routledge / Taylor and Francis, 2017

Biofluids, Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of endothelial gene expression.

Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z, Journal of Biomechanics 50(): 3-10, 2017

Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF., Journal of Biomechanics 50(): 11-19, 2017

Endothelial epigenetics and its role in mediating biomechanical stress of hypertension.

Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ, J. Hypertension 34; Suppl 1-ISH 2016(): e371, 2016

Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF., J Am Heart Assoc 18;5(4). pii: e003170.(): doi: 10.1161/JAHA.115.003170, 2016

Lymph flow regulates collecting lymphatic vessel maturation in vivo

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML., J. Clin Invest. 125(): 2995-3007, 2015

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR., J Controlled Release 210(): 39-47, 2015

Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF., BMC Genomics 16(): 506, 2015

Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR., Am. Chem. Soc. Nano. 9(7): 6785-6793, 2015

Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF., Arterioscler Thromb Vasc Biol 35(): 1317-1326, 2015

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