PEOPLE

Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384

Email: whancock@pennmedicine.upenn.edu

Research Expertise

Research Interests

Transplant immunobiology, inflammation and mechanisms of disease

Research Summary

New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.

CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Itmat Expertise

Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors

Graduate Groups

Immunology

Education

M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College o fPathologists of Australasia, 1989

Specialty Certification

Fellow of the Royal College of Pathologists of Australasia, 1989

Postgraduate Training

Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986

Awards and Honors

Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996

Memberships and Professional Organizations

International Society of Nephrology, 1983 - Present
The Transplantation Society, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - Present
American Association of Immunologists, 1986 - Present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - Present
American Society for Investigative Pathology, 1994 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
American Society for Hematology, 1997 - Present
National Kidney Foundation, 1997 - 2001
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
British Heart Foundation, 2007 - 2007
National Institutes of Health, 2007 - 2007
National Institutes of Health, 2008 - 2008
Wessex Medical Research, 2008 - 2008
The Wellcome Trust, 2008 - 2009
University of Pennsylvania, 2008 - Present
National Institutes of Health, 2008 - 2008
National Health and Medical Research Council of Australia, 2008 - 2008
National Institutes of Health, 2009 - 2009
Australian National University, 2009 - 2010
International Pancreas and Islet Transplant Association, 2009 - Present
National Institutes of Health, 2009 - 2009
Arthritis Research UK, 2010 - 2010
Australian National University, 2010 - 2010
National Institutes of Health, 2010 - 2010
Swiss National Science Foundation, 2010 - 2010
National Institutes of Health, 2010 - 2010
National Institutes of health, 2011 - 2011
American Association for Cancer Research, 2011 - Present
American Society for Microbiology, 2011 - Present
National Institutes of Health, 2011 - 2011
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
American Chemical Society, 2011 - Present
National Institutes of Health, 2012 - 2017
Broad Medical Research Program, 2012 - 2012
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2013 - 2013
Leukaemia & Lymphoma Research, 2013 - 2013
National Institutes of Health, 2013 - 2014
Austrian Science Fund, 2013 - 2013
Children's Hospital of Philadelphia, 2013 - 2013
Department of Defense, 2013 - 2013
Medical Research Council (UK), 2013 - 2013
National Institutes of Health, 2013 - 2013
National Institutes of Health, 2014 - 2014
National Institutes of Health, 2014 - 2014
Department of Defense, 2014 - 2014
Israel Science Foundation, 2014 - 2014
National Institutes of Health, 2015 - 2015
National Institutes off Health, 2015 - 2015
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
Veterans Administration, 2016 - 2016
National Institutes of Heath, 2016 - 2016
National Institute so fHealth, 2017 - 2017
National Institutes of Health, 2017 - 2017
National Institutes of Health, 2017 - 2017
Children's Hospital of Philadelphia, 2017 - 2017
National Institutes of Health, 2018 - 2018

Web Links


Selected Publications

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.

Negorev D, Beier UH, Zhang T, Quatromoni JG, Bhojnagarwala P, Albelda SM, Singhal S, Eruslanov E, Lohoff FW, Levine MH, Diamond JM, Christie JD, Hancock WW, Akimova T., Scientific Reports 8(1): 3135, 2018

Utility of IL-2 complexes in promoting the survival of murine orthotopic forelimb vascularized composite allografts.

Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, Zhang Y, Qin L, Levine MH, Hancock WW, Levin LS., Transplantation 102(): 70-78, 2018

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA., Nature Communications 9(): 53, 2018

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60.

Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S., PLoS One, 2017

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW., Scientific Reports 17(): 8626, 2017

Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors.

Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW., JCI Insight, 2017

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.

Woods DM, Woan K, Wang D, Sodré AL, Cheng F, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM., Blood 130(): 146-155, 2017

The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing.

Laskin BL, Jiao J, Baluarte HJ, Amaral S, Furth SL, Akimova T, Hancock WW, Levine MH, Reese PP, Beier UH., Transplantation Direct 3(): e199, 2017

Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions.

Bin Dhuban K, d'Hennezel E, Nagai Y, Xiao Y, Shao S, Istomine R, Alvarez F, Ben-Shoshan M, Ochs H, Mazer B, Li B, Sekine C, Berezov, A, Hancock W, Torgerson TR, Greene M I, Piccirillo CA., Science Immunology 2,(): eaai9297, 2017

Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments.

Angelin A, De Gomez LG, Dahiya S, Jiao J, Guo L, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Wang W, Laskin BL, Blair IA, Wallace DC, Hancock WW, Beier UH., Cell Metabolism 25(): 1282-1293, 2017

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