PEOPLE

Brian Harding, DPhil, BMBCh

Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
University of Pennsylvania Perelman School of Medicine

Contact InformationThe Children's Hospital of Philadelphia
Department of Pathology
S 34th St & Civic Center Blvd
Main Building, Suite 5NW15
Philadelphia, PA 19104
Office: 2967-426-5504
Fax: 267-426-7783

Itmat Expertise

Developmental neuropathology
Malformations and peditatric degenerative disorders of the nervous sytem

Education

B.A. (Animal Physiology), Worcester College, University of Oxford, 1969
M.A. (Animal Physiology), Worcester College, University of Oxford, 1976
B.M. B.Ch. University of Oxford ( & St George’s Hospital Medical School London), 1976
D.Phil. (Thesis: A Study of certain nuclei of the thalamus), Dept of Anatomy University of Oxford, 1976

Specialty Certification

MRCPath Royal College of Pathologists (Neuropathology), 1982
FRCPath Royal College of Pathologists (Neuropathology), 1994

Postgraduate Training

House officer in Medicine, St James Hospital Balham SW12, 1976-1976
House officer in Surgery, St George’s Hospital, Hyde Park Corner, London SW1, 1976-1977
Senior House officer/Registrar, Pathology St George’s Hospital, London SW1 & SW17, 1977-1979
Senior Registrar in Histopathology, St George’s Hospital, London SW17, 1979-1980
Senior Registrar in Neuropathology, National Hospital for Neurology and Neurosurgery, Queens Square, London WC1, 1980-1983

Awards and Honors

American Association of Neuropathologists, Award for Meritorious Contributions to Neuropathology, 2018

Memberships and Professional Organizations

British Neuropathology Society, 1981 - Present
British Paediatric Neurology Association, 1985 - 2008
British Neuropathology Society, 1986 - 1989
American Association of Neuropathologists, 1989 - Present
Royal College of Pathologists (UK) scheme, 1990 - Present
Societe Francaise de Neuropathologie, 1990 - 2008
Clinical Pathology Accreditation Ltd (UK), 2004 - 2008
Royal College of Pathologists (UK) scheme, 2005 - 2008
Royal College of Pathologists (UK) scheme, 2007 - 2008
The College of Physicians of Philadelphia, 2010 - Present

Web Links


Selected Publications

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium., New England Journal of Medicine 377(17): 1648-1656, 2017, PMID:29069555

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Deregulated expression of EZH2 in congenital brainstem disconnection

Barth PG, Aronica E, Fox S, Fluiter K, Weterman MA, Poretti A, Miller DC, Boltshauser E, Harding B, Santi M, Baas F, Neuropathol Appl Neurobiol 43(4): 358-365, 2017, PMID:27886392

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Developmental and perinatal brain diseases.

Adle-Biassette H, Golden JA, Harding B, Handbook Clin Neurol 145(): 51-78, 2017, PMID:28987191

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Anaplastic transformation in a Pilocytic astrocytoma

Lopez G, Perry A, Harding B, Santi M, J Neuropath Exp Neurol 76(): 511-2, 2017

Opiate Cerebellar toxicity: Correlation of imaging and neuropathology in a child.

Harding B, Voosough A, J Neuropath Exp Neurol 76(): 527, 2017

Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.

Harding BN, Moccia A, Drunat S, Soukarieh O, Tubeuf H, Chitty LS, Verloes A, Gressens P, El Ghouzzi V, Joriot S, Di Cunto F, Martins A, Passemard S, Bielas SL, Am J Hum Genet. 99(2): 511-20, 2016, PMID:27453579

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Pontine tegmental cap dysplasia: neuropathological confirmation of a rare clinical/radiological syndrome.

Harding B, Vossough A, Goldberg E, Santi M, Neuropathology and Applied Neurobiology 42(3): 301-6, 2016, PMID:26331236

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Degos disease mimicking primary vasculitis of the CNS

Gmuca S, Boos MD, Treece A, Narula S, Billinghurst L, Bhatti T, Laje P, Perman MJ, Vossough A, Harding B, Burnham J, Banwell B., Neurol Neuroimmunol Neuroinflamm 3(2): E206, 2016, PMID:26894208

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A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease

Rajakulendran S, Pitceathly RD, Taanman JW, Costello H, Sweeney MG, Woodward CE, Jaunmuktane Z, Holton JL, Jacques TS, Harding BN, Fratter C9, Hanna MG, Rahman S, PLoS One 11(1): e0145500, 2016, PMID:26735972

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Microlissencephaly with multinucleated neurons results from failed cytokinesis due to truncating mutations in Citron kinase

Harding BN, Moccia A, Chtty L and Bielas S, Clin Neuropath 35(): , 2016