PEOPLE

Mariarita Santi, MD, PhD

Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
University of Pennsylvania Perelman School of Medicine

Contact InformationChildren's Hospital of Philadelphia
324 South 34th Street
Room 5NW26
Philadelphia, PA 19104
Office: 215-590-3184
Fax: 215- 590-1736

Email: santim@email.chop.edu

Clinical Expertise

Pediatric and Adult Brain Tumors, Pediatric and Adult Muscle Disease, Tumor Banks

Education

B.S. Classic Lyceum Reggio Emilia, Italy, 1974
M.D. Modena University Medical School, Modena, Italy, 1982
Ph.D. (Pharmacology), Modena University , 1988

Specialty Certification

Educational Commission for Foreign Medical Graduates (ECFMG)Certified (# 0-480-266-6)., 1993
FLEX exam for the State of Maryland, 1993
Diplomate of the American Board of Pathology in Anatomic Pathology, 1998
Diplomate of the American Board of Pathology in Neuropathology., 2001
New York State Department of Health Certificate of Qualification in general histopathology, 2005
American Board of Pathology.
Successufly fulfilled the requirements for voluntary recertification., 2014

Postgraduate Training

Resident in Endocrinology, Modena University Medical Center, Modena, Italy., 1982-1985
Postdoctoral Fellow, Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, D.C., 1984-1985
Research Associate, Fidia-Georgetown Institute for the Neuroscience, Georgetown University Medical School, Washington D.C., 1985-1990
Research Associate , FIDIA Research Laboratory, Abano Terme, Padova, Italy, 1990-1991
Resident in Anatomical Pathology, Department of Pathology and Laboratory Medicine
George Washington University Medical Center,Washington D.C., 1994-1997
Fellowship, Surgical Pathology, Department of Pathology, Georgetown University Medical Center, Washington D.C., 1997-1998
Fellowship, Neuropathology, Department of Neuropathology Armed Forces Institute of Pathology (AFIP), Washington D.C., 1998-2000
Training, Developmental and Pediatric Neuropathology, Department of Pathology and Laboratory Medicine,
Children Hospital of Philadelphia, Philadelphia, 1999-1999

Awards and Honors

Honors, MD Summa cum Laude, Modena University Medical School, Modena, Italy., 1982
Residency, Summa cum Laude in Endocrinology, Modena University Med. School, Modena,Italy., 1985

Memberships and Professional Organizations

International Brain Research Organization (IBRO), 1985 - 2005
Society for Neuroscience, 1985 - 2005
College of American Pathologist, 1995 - 2008
American Society of Clinical Pathologist, 1995 - 2003
American Association of Neuropathologist, 2003 - Present
The Scientific Award Competition, Ogden Bruton Category, Uniformed Service Pediatric Seminar, 2004 - 2004
Neuropathology Review Committee, Brain Committee of the Southwest Oncology Group(SWOG), 2004 - 2009
Children’s Oncology Group (COG), 2004 - Present
US and Canadian Academy of Pathology, 2004 - Present
Society for Pediatric Pathology, 2009 - Present

Web Links


Selected Publications

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.

Panwalkar Pooja, Clark Jonathan, Ramaswamy Vijay, Hawes Debra, Yang Fusheng, Dunham Christopher, Yip Stephen, Hukin Juliette, Sun Yilun, Schipper Matthew J, Chavez Lukas, Margol Ashley, Pekmezci Melike, Chung Chan, Banda Adam, Bayliss Jill M, Curry Sarah J, Santi Mariarita, Rodriguez Fausto J, Snuderl Matija, Karajannis Matthias A, Saratsis Amanda M, Horbinski Craig M, Carret Anne-Sophie, Wilson Beverly, Johnston Donna, Lafay-Cousin Lucie, Zelcer Shayna, Eisenstat David, Silva Marianna, Scheinemann Katrin, Jabado Nada, McNeely P Daniel, Kool Marcel, Pfister Stefan M, Taylor Michael D, Hawkins Cynthia, Korshunov Andrey, Judkins Alexander R, Venneti Sriram, Acta neuropathologica 134(5): 705-714, 2017, PMID:28733933

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Common and variable clinical, histological, and imaging findings of recessive RYR1-related centronuclear myopathy patients.

Abath Neto O, Moreno CAM, Malfatti E, Donkervoort S, Böhm J, Guimarães JB, Foley AR, Mohassel P, Dastgir J, Bharucha-Goebel DX, Monges S, Lubieniecki F, Collins J, Medne L, Santi M, Yum S, Banwell B, Salort-Campana E, Rendu J, Fauré J, Yis U, Eymard B, Cheraud C, Schneider R, Thompson J, Lornage X, Mesrob L, Lechner D, Boland A, Deleuze JF, Reed UC, Oliveira ASB, Biancalana V, Romero NB, Bönnemann CG, Laporte J, Zanoteli E., Neuromuscul Disord. 27(11): 975-985, 2017, PMID:28818389

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Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

Majzner Robbie G, Simon Jason S, Grosso Joseph F, Martinez Daniel, Pawel Bruce R, Santi Mariarita, Merchant Melinda S, Geoerger Birgit, Hezam Imene, Marty Virginie, Vielh Phillippe, Daugaard Mads, Sorensen Poul H, Mackall Crystal L, Maris John M, Cancer 123(19): 3807-3815, 2017, PMID:28608950

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Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.

Bosse Kristopher R, Raman Pichai, Zhu Zhongyu, Lane Maria, Martinez Daniel, Heitzeneder Sabine, Rathi Komal S, Kendsersky Nathan M, Randall Michael, Donovan Laura, Morrissy Sorana, Sussman Robyn T, Zhelev Doncho V, Feng Yang, Wang Yanping, Hwang Jennifer, Lopez Gonzalo, Harenza Jo Lynne, Wei Jun S, Pawel Bruce, Bhatti Tricia, Santi Mariarita, Ganguly Arupa, Khan Javed, Marra Marco A, Taylor Michael D, Dimitrov Dimiter S, Mackall Crystal L, Maris John M, Cancer cell 32(3): 295-309.e12, 2017, PMID:28898695

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Assessment of PD-L1 expression and tumor associated immune cells in pediatric cancer tissue.

Majzner R, Simon JS, Gross JF, Martinez D, Pawel B, Santi M, Merchant M, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen P, Mackall C and Maris J., Cancer Epub ahead of print (): , 2017

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF, Neoplasia 19(3): 216-225, 2017, PMID:28167297

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Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.

Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, La Rocca G, Santi M, Lewis PW, Hawkins C, Melnick A, David Allis C, Thompson CB, Chinnaiyan AM, Judkins AR, Venneti S., Sci Transl Med. 8(366): 366ra161, 2016, PMID:27881822

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Deregulated expression of EZH2 in congenital brainstem disconnection.

Barth PG1,2, Aronica E2, Fox S3, Fluiter K4, Weterman MA4, Poretti A5, Miller DC6, Boltshauser E7, Harding B8, Santi M8, Baas F4., Neuropathol Appl Neurobiol In press(): , 2016, PMID:27886392

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Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis.

Ramaswamy V, Hielscher T, Mack S, Lassaletta A, Lin T, Pajtler K, Jones DTW, Luu B, Cavalli FMG, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R, Lipp ES, Dunham C, Hukin J, Eisenstat D, Fulton D, Van Landeghem F, Santi M, Van Veelen-Vincent M-L, Van Meir E, Osuka S, Fan X, Muraszko K, Tirapelli D, Oba-Shinjo S, Marie S, Carlotti C, Lee JY, Rao AN, Giannini C, Faria C, Nunes S, Mora J, Hamilton R, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognar I, Klekner A, Hortobàgyi T, Leary S, Ermoian R, Olson J, Leonard J, Gardner C, Grajkowska W, Chambless L, Cain J, Eberhart C, Adsan S, Massimino M, Giangaspero F, Buttarelli F, Packer RJ, Emery L, Yong W, Soto H, Liau L, Everson R, Grossbach A, Shalaby T, Groszer M, Karajannis M, Zagzag D, Wheeler H, Von Hoff K, Alonso M, Tuñon T, Schűller U, Zitterbart K, Sterba J, Chan J, Guzman M, Elbabaa S, Colman H, Dhall G, Fisher P, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro A, Pollack I, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins C, Rutka J, Dirks P, Pfister S, Merchant T, Gilbert M, Armstrong TS, Korshunov A, Ellison D, and Taylor MD, Journal of Clinical Oncology 34(21): , 2016, PMID:27269943

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Whole chromosome 7 gain predicts higher risk of recurrence in pediatric pilocytic astrocytomas independently from KIAA1549-BRAF fusion status.

Roth JJ, Fierst TM, Waander A, Yimei L, Biegel JA, Santi M, Journal of Neuropathology and Experimental Neurology 75(4): 306-315, 2016, PMID:26945035

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