PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976
M.D. Tufts University School of Medicine, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Sandoz Award in Neurology, 1976
Mead Johnson Excellence in Research Award, 1976
Roche Laboratories Neurosciences Research Award, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Elected Member, American Society of Clinical Investigation, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015
The Mayo Clinic Irving S. Cooper Professorship, “New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies”, Mayo Clinic, Rochester, MN, 21 August, 2017, 2017

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
American Association of Pathologists, - Present
American Association of Neuropathologists, - Present
American Society for Investigative Pathology, - Present
American Society for Clinical Investigators, - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
Association of American Physicians, - Present
Killam Research Fellowship Program, The Canada Council, - Present
International Academy of Pathology, Abstract Review Board member, - Present
National Institutes of Health Neurology A Study Section, - Present
Elwyn Institute, Elwyn, PA, - Present
National Sleep Foundation, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Institutes of Health, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
National Campaign to End Neurological Disorders (END)), - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Dystonia Medical Research Foundation, - Present
Society for Neuroscience, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Sleep Foundation, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
American Society for Cell Biology, - Present
Society for Neuroscience, - Present
Institute of Medicine Class of 2002, - Present
National Institute on Aging, Board of Scientific Councilors, - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
National Institute on Aging, - Present
American Brain Tumor Association, - Present
National Institutes of Neurologic Disorders and Stroke, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
Alzheimer's Association, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
National Institutes of Child Health and Human Development, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present

Web Links


Selected Publications

Is multiple system atrophy an infectious disease?

Wenning Gregor, Trojanowski John Q, Kaufmann Horacio, Wisniewski Thomas, Rocca Walter A, Low Phillip A, Annals of neurology, 2018, PMID:29293269

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Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

He Zhuohao, Guo Jing L, McBride Jennifer D, Narasimhan Sneha, Kim Hyesung, Changolkar Lakshmi, Zhang Bin, Gathagan Ronald J, Yue Cuiyong, Dengler Christopher, Stieber Anna, Nitla Magdalena, Coulter Douglas A, Abel Ted, Brunden Kurt R, Trojanowski John Q, Lee Virginia M-Y, Nature medicine 24(1): 29-38, 2018, PMID:29200205

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Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Rey Nolwen L, George Sonia, Steiner Jennifer A, Madaj Zachary, Luk Kelvin C, Trojanowski John Q, Lee Virginia M-Y, Brundin Patrik, Acta neuropathologica 135(1): 65-83, 2018, PMID:29209768

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Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.

Irwin David J, McMillan Corey T, Xie Sharon X, Rascovsky Katya, Van Deerlin Vivianna M, Coslett H Branch, Hamilton Roy, Aguirre Geoffrey K, Lee Edward B, Lee Virginia M Y, Trojanowski John Q, Grossman Murray, Brain : a journal of neurology 141(1): 288-301, 2018, PMID:29228211

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Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Guerreiro Rita, Ross Owen A, Kun-Rodrigues Celia, Hernandez Dena G, Orme Tatiana, Eicher John D, Shepherd Claire E, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaroslau, Van Deerlin Vivianna, Serrano Geidy E, Beach Thomas G, Lesage Suzanne, Galasko Douglas, Masliah Eliezer, Santana Isabel, Pastor Pau, Diez-Fairen Monica, Aguilar Miquel, Tienari Pentti J, Myllykangas Liisa, Oinas Minna, Revesz Tamas, Lees Andrew, Boeve Brad F, Petersen Ronald C, Ferman Tanis J, Escott-Price Valentina, Graff-Radford Neill, Cairns Nigel J, Morris John C, Pickering-Brown Stuart, Mann David, Halliday Glenda M, Hardy John, Trojanowski John Q, Dickson Dennis W, Singleton Andrew, Stone David J, Bras Jose, The Lancet. Neurology 17(1): 64-74, 2018, PMID:29263008

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A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.

Wang Hua, Stewart Tessandra, Toledo Jon B, Ginghina Carmen, Tang Lu, Atik Anzari, Aro Patrick, Shaw Leslie M, Trojanowski John Q, Galasko Douglas R, Edland Steven, Jensen Poul H, Shi Min, Zhang Jing, Journal of Alzheimer's disease : JAD 61(4): 1541-1553, 2018, PMID:29376878

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TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.

Berson Amit, Sartoris Ashley, Nativio Raffaella, Van Deerlin Vivianna, Toledo Jon B, Porta Sílvia, Liu Shichong, Chung Chia-Yu, Garcia Benjamin A, Lee Virginia M-Y, Trojanowski John Q, Johnson F Brad, Berger Shelley L, Bonini Nancy M, Current biology : CB 27(23): 3579-3590.e6, 2017, PMID:29153328

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Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease.

Horgusluoglu-Moloch Emrin, Nho Kwangsik, Risacher Shannon L, Kim Sungeun, Foroud Tatiana, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Lovestone Simon, Simmons Andrew, Weiner Michael W, Saykin Andrew J, Neurobiology of aging 60(): 92-103, 2017, PMID:28941407

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Clinicopathological correlations in behavioural variant frontotemporal dementia.

Perry David C, Brown Jesse A, Possin Katherine L, Datta Samir, Trujillo Andrew, Radke Anneliese, Karydas Anna, Kornak John, Sias Ana C, Rabinovici Gil D, Gorno-Tempini Maria Luisa, Boxer Adam L, De May Mary, Rankin Katherine P, Sturm Virginia E, Lee Suzee E, Matthews Brandy R, Kao Aimee W, Vossel Keith A, Tartaglia Maria Carmela, Miller Zachary A, Seo Sang Won, Sidhu Manu, Gaus Stephanie E, Nana Alissa L, Vargas Jose Norberto S, Hwang Ji-Hye L, Ossenkoppele Rik, Brown Alainna B, Huang Eric J, Coppola Giovanni, Rosen Howard J, Geschwind Daniel, Trojanowski John Q, Grinberg Lea T, Kramer Joel H, Miller Bruce L, Seeley William W, Brain : a journal of neurology 140(12): 3329-3345, 2017, PMID:29053860

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Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease.

Phillips Jeffrey S, Da Re Fulvio, Dratch Laynie, Xie Sharon X, Irwin David J, McMillan Corey T, Vaishnavi Sanjeev N, Ferrarese Carlo, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Wolk David A, Grossman Murray, Neurobiology of aging 63(): 75-87, 2017, PMID:29223682

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