PEOPLE

Douglas C. Wallace, PhD

Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Disease
Children's Hospital of Philadelphia

Contact InformationThe Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard

Philadelphia, PA, 19104-4302
Office: 267-425-3034

Itmat Expertise

Mitochondrial and Epigenomic Medicine

Graduate Groups

Cell and Molecular Biology

Education

B.S. (Genetics, Developmental Biology), Cornell University, Ithaca, NY, 1968
M. Phil. (Microbiology and Human Genetics), Yale University, New Haven CT, 1972
PhD (Microbiology and Human Genetics), Yale University, New Haven CT, 1975

Specialty Certification

American Board of Medical Genetics Diplomate, Ph.D. Medical Genetics, 1989
American Board of Medical Genetics Diplomate, Clinical Molecular Genetics, 1993

Postgraduate Training

Predoctoral Research, Department of Microbiology, Yale University, 1971-1975
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976

Awards and Honors

Mellon Foundation Fellow, Stanford University, 1978-1979
Hume Faculty Scholar, Stanford University, 1981-1982
Most Valuable Professor, Emory University School of Medicine, Class of 1988, 1988
Most Animated Instructor, Emory University School of Medicine, Class of 1990, 1990
Robert W. Woodruff Professor of Molecular Genetics, 1991-2002
William Allan Award, American Society of Human Genetics, 1994
Member of American Academy for Microbiology, 1995
Member of National Academy of Sciences, 1995
Docteur Honoris Causa, Universite Victor Segalen Bordeaux 2, 2000
Passano Award 2000 for mitochondrial genetics, with G. Attardi, 2000
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 2000
Donald Bren Professor of Biological Sciences and Molecular Medicine, University of California, Irvine, 2002-2010
Member American Academy of Arts and Sciences, 2004
Fellow, American College of Medical Genetics, 2004
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2005
Albert Einstein Visiting Professorship, Chinese Academy of Sciences, 2006
Lauds & Laurels, University of California, Irvine, 2006
Excellence in Teaching Award, University of California, Irvine, School of Medicine, 2006
Robert J. & Claire Pasarow Award for contributions to Cardiovascular Disease, 2006
Faculty Achievement Award, University of California, Irvine Alumni Association, 2006
Member of Institute of Medicine of the National Academies, 2009
Michael and Charles Barnett Endowed Chair of Pediatric Mitochondrial Medicine and Metabolic Disease, Children's Hospital of Philadelphia, University of Pennsylvania, 2010
Gruber Foundation Genetics Prize, 2012
American College of Physicians Award for Outstanding Work in Science as Related to Medicine, 2013
Foreign Member of The Accademia Nazionale Delle Sceince Detta Dei XL, Rome, Italy, 2016
Johnson & Johnson, "2017 Dr. Paul Janssen Award for Biomedical Research", Beerse Award Ceremony, Belgium; and Scientific Symposium & Luncheon, New York, 2017
The Franklin Institute's "2017 Benjamin Franklin Medal in Life Science Laureate", Philadelphia, PA, 2017

Memberships and Professional Organizations

American Society for Microbiology, 1968 - present
The American Association for the Advancement of Science, 1972 - present
Sigma Xi, 1972 - present
Society for Inherited Metabolic Disorders, 1989 - present
Human Gene Mapping Consortium, 1993 - 2002
American Society of Human Genetics, 1993 - present
United Mitochondrial Disease Foundation, 1996 - 2008
International Human Genome Organization, 1999 - present
National Institute of Aging, 2002 - 2005
Autism Speaks, 2009 - present
National Heart Lung and Blood Institute, 2010 - present

Web Links


Selected Publications

Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function.

Weisz Eliana D, Towheed Atif, Monyak Rachel E, Toth Meridith S, Wallace Douglas C, Jongens Thomas A, Human molecular genetics 27(1): 95-106, 2018, PMID:29106525

Read article

A novel inborn error of the coenzyme Q10 biosynthesis pathway: cerebellar ataxia and static encephalomyopathy due to COQ5 C-methyltransferase deficiency.

Malicdan May Christine V, Vilboux Thierry, Ben-Zeev Bruria, Guo Jennifer, Eliyahu Aviva, Pode-Shakked Ben, Dori Amir, Kakani Sravan, Chandrasekharappa Settara C, Ferreira Carlos R, Shelestovich Natalia, Marek-Yagel Dina, Pri-Chen Hadass, Blatt Ilan, Niederhuber John E, He Langping, Toro Camilo, Taylor Robert W, Deeken John, Yardeni Tal, Wallace Douglas C, Gahl William A, Anikster Yair, Human mutation 39(1): 69-79, 2018, PMID:29044765

Read article

Homozygous Boricua TBCK Mutation Causes Neurodegeneration and Aberrant Autophagy

Ortiz-González XR, Tintos-Hernández JA, Keller K, Li X,, Foley AR, Bharucha-Goebel DX, Kessler SK, Yum SW, Crino PB, He M, Wallace DC, Bönnemann CG., Ann Neurol, 2017

Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP.

Sonney Sanjay, Leipzig Jeremy, Lott Marie T, Zhang Shiping, Procaccio Vincent, Wallace Douglas C, Sondheimer Neal, PLoS computational biology 13(12): e1005867, 2017, PMID:29227991

Read article

Homozygous Boricua TBCK Mutation Causes Neurodegeneration and Aberrant Autophagy.

Ortiz-González Xilma R, Tintos-Hernández Jesus A, Keller Kierstin, Li Xueli, Foley A Reghan, Bharucha-Goebel Diana X, Kessler Sudha K, Yum Sabrina W, Crino Peter B, He Miao, Wallace Douglas C, Bönnemann Carsten G, Annals of neurology, 2017, PMID:29283439

Read article

Mitochondrial Etiology of Neuropsychiatric Disorders.

Pei Liming, Wallace Douglas C, Biological psychiatry, 2017, PMID:29290371

Read article

Resistive flow sensing of vital mitochondria with nanoelectrodes.

Zand Katayoun, Pham Ted D A, Li Jinfeng, Zhou Weiwei, Wallace Douglas C, Burke Peter J, Mitochondrion 37(): 8-16, 2017, PMID:28655663

Read article

Association Between Mitochondrial DNA Haplogroup Variation and Autism Spectrum Disorders.

Chalkia Dimitra, Singh Larry N, Leipzig Jeremy, Lvova Maria, Derbeneva Olga, Lakatos Anita, Hadley Dexter, Hakonarson Hakon, Wallace Douglas C, JAMA psychiatry 74(11): 1161-1168, 2017, PMID:28832883

Read article

An X-chromosome linked mouse model (Ndufa1S55A) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases.

Kim Chul, Potluri Prasanth, Khalil Ahmed, Gaut Daria, McManus Meagan, Compton Shannon, Wallace Douglas C, Yadava Nagendra, Neurochemistry international 109(): 78-93, 2017, PMID:28506826

Read article

A Mitochondrial Etiology of Neuropsychiatric Disorders.

Wallace Douglas C, JAMA psychiatry 74(9): 863-864, 2017, PMID:28614546

Read article