Gerald B. Wertheim, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736


Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis


BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
summa cum laude, Yale University, 1994
The Werner Bergmann Award in Chemistry, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
Society of Hematopathology, 2015 - Present
American Society of Hematology, 2015 - Present

Selected Publications

Clusters of CD123-Positive Plasmacytoid Dendritic Cells in JMML

Modi M, Cotner C, Wertheim G, Paessler M, Tasian SK, Luo M, United States and Canadian Academy of Pathology 2019 Meeting National Harbor, Maryland, 2019, 2019

Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia

Rosenthal J, Naqvi AS, Luo M, Wertheim G, Paessler M, Thomas-Tikhonenko A, Rheingold SR, Pillai V, Am J Hematol, 2018, PMID:30058145

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Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells.

Krevvata M, Shan X, Zhou C, Dos Santos C, Habineza Ndikuyeze G, Secreto A, Glover J, Trotman W, Brake-Silla G, Nunez-Cruz S, Wertheim G, Ra HJ, Griffiths E, Papachristou C, Danet-Desnoyers G, Carroll M, Haematologica 103(6): 959-971, 2018, PMID:29545344

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Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype

Sarthy J, Zha J, Babushok D, Shenoy A, Fan JM, Wertheim G, Himebauch A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS, Blood Adv 2(2): 120-125, 2018, PMID:29365320

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PERK-miR-211 integrates oncogenic signaling with circadian oscillation and protein synthesis

Bu Y, Yoshida A, Chitnis N, Altman A, Tameire F, Oran A, Gennaro v, Armeson K, McMahon S, Wertheim G, Dang C, Ruggero D, Koumenis C, Fuchs S, Diehl JA, Nature Cell Biology 20(1): 104-115, 2018, PMID:29230015

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Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure.

Ding YY, Stern JW, Jubelirer TF, Wertheim GB, Li F, Chang F, Gu Z, Mullighan CG, Li Y, Harvey RC, Chen IM, Willman CL, Hunger SP, Li MM, Tasian SK, Haematologica, 2018, PMID:29773603

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Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells

Hurtz C, Tasian SK, Wertheim G, Ruggeri B, Stubbs MC, Perl AE, Carroll M, 59th Annual American Society for Hematology Meeting and Exposition, Atlanta, GA, 2017

Clinical Impact of Genomic Information in Pediatric Leukemia

Lalonde E, Wertheim G, Li MM, Front Pediatr 5(): 263, 2017, PMID:29312903

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Flow cytometry in pediatric hematopoietic malignancies

Li J, Wertheim G, Paessler M, Pillai V, Clinics in Laboratory Medicine 37(): 879-893, 2017, PMID:29128074

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MafB is a novel enhancer of oncogenic Notch signaling in T-cell acute lymphoblastic leukemia.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Rajeswaran M, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S and Pear WS, Science Signaling 10(505): , 2017, PMID:29138297

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