Megan S. Lim, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Director, Hematopathology

Contact InformationDepartment of Pathology and Laboratory Medicine
Stellar Chance Office Suite 609C
422 Curie Blvd.

Philadelphia, PA, 19104
Office: 215-898-4719
Fax: 215-898-9969


Specialty Division


Itmat Expertise

hematologic cancer
molecular pathogenesis
genomic analysis
mass spectrometry driven proteomics


BS (Cell and Microbiology), University of Calgary, 1983
MS (Biochemistry, Cell Regulation Group, Department of Medical Biochemistry, Faculty of Medicine), University of Calgary, 1985
MD (Medicine), University of Calgary, 1988
PhD (Molecular Oncology), University of Calgary joint with National Cancer Institute, National Institute of Health, 1999

Specialty Certification

Licentiate of Medical Council of Canada (LMCC), 1988
Fellow, Royal College of Physicians and Surgeons of Canada (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Hematology), 1999
Diplomate of American Board of Pathology (Molecular Genetic Pathology), 2003

Postgraduate Training

Residency in Anatomic Pathology, University of Calgary (Calgary, Alberta), 1988-1993
Chief Resident, Pathology Training Program, Foothills Hospital (Calgary, Alberta), 1991-1991
Research Fellowship, Cancer Research Group, Faculty of Medicine, University of Calgary (Calgary, Alberta), 1993-1995
Fellowship, Hematopathology, Lab of Pathology, National Cancer Institute, National Institutes of Health, (Bethesda, MD), 1995-1998
Mid-Career Women Faculty Professional Development Seminar, Association of American Medical Colleges (Washington, DC), 2003-2003
Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health (Boston, MA), 2012-2012

Awards and Honors

Louise McKinney Scholarship for Outstanding Academic Achievement, University of Calgary, 1982
Faculty of Science Dean’s List, University of Calgary, 1982
Alberta Heritage Foundation for Medical Research Summer Studentship, 1983
Alberta Heritage Foundation for Medical Research Studentship, 1983-1985
Alberta Heritage Foundation for Medical Research Part-Time Studentship (while in MD program), 1985-1987
Nominated by Medical Research Council of Canada for the Royal Society of Canada’s Women in Scholarship Alice Wilson Award, 1993
Fee Scholarship Award, Faculty of Graduate Studies, University of Calgary, 1994-1997
National Institutes of Health Fogarty Visiting Fellowship, 1996-1998
Junior Scientist Award, Canadian Association of Pathology, 2000
Young Investigator Award, Children’s Oncology Group, 2002
Translational Research Award, Children’s Oncology Group, 2004
Best Doctors of America, 2005-2014
Pluto Society, 2015

Memberships and Professional Organizations

Canadian Medical Association, 1985 - 1993
Canadian Association of Pathologists, 1988 - Present
Royal College of Physicians and Surgeons of Canada, 1993 - Present
Canadian Medical Protective Association, 1993 - 2000
American Association for Cancer Research, 1994 - Present
American Society of Hematology, 1995 - Present
United States and Canadian Academy of Pathology, 1995 - Present
Society for Hematopathology/European Association for Haemotopathology, 1995 - Present
American Association for the Advancement of Science, 1997 - 1999
Association for Molecular Pathology, 1998 - 2013
College of Physicians and Surgeons of Ontario, 1998 - 2003
European Society of Hematopathology, 1998 - 2016
Canadian Hematology Society, 1999 - 2001
Children’s Oncology Group, 2002 - Present
American Society for Investigative Pathology, 2002 - Present
American Biologic Resources and Facilities, 2005 - Present
American Society of Mass Spectrometry, 2006 - 2006
Michigan Society of Pathologists, 2007 - Present
A. J. French Society, 2007 - Present
American Society for Clinical Pathology, 2008 - Present
St. Baldrick's Foundation, 2011 - Present
Lymphoma Research Foundation, 2011 - Present
College of American Pathologists, 2014 - 2014
United States Cutaneous Lymphoma Consortium, 2014 - 2014
University of Michigan, 2016 - 2016
Department of Defense Congressionally Directed Medical Research Programs (CDMRP), 2016 - Present
National Science Center, Poland, 2017 - 2017
Ontario Genomics; Grant Review - Genome Canada, Large-Scale Applied Research Project on Genomics in Precision Health., 2017 - 2017

Web Links

Selected Publications

Poster presentation "Characterization of Histone Post-Translational Modifications of Cutaneous T-cell Lymphomas"

Önder Ö, Rolland DCM, Yuan Z-F, Garcia BA, Lim MS and Elenitoba-Johnson KSJ, 65thAmerican Society for Mass Spectrometry Conference on Mass Spectrometry & Allied Topics, 2017

Functional Proteogenomics Reveals Biomarkers and Therapeutic Targets in Lymphoid Cancer

Rolland DCM, Basrur V, Jeon YK, McNeil-Schwalm C, Fermin D, Conlon KP, Zhou Y, Ng SY, Tsou C-C, Brown NA, Thomas DG,. Bailey NG, Omenn GS, Nesvizhskii AI, Weinstock DM, Faryabi RB, Lim MS, and Elenitoba-Johnson KSJ, Proc Natl Acad Sci USA 114(25): 6581-86, 2017, PMID:28607076

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Target and Agent Prioritization for Children’s Oncology Group-National Cancer Institute Pediatric MATCH Trial

Allen CE, Leatsch T, Mody R, Irwin MS, Lim MS, Adamson P, Seibel N, Parsons DW, Cho YJ and Janeway K on behalf of the Pediatric MATCH Target and Agent Prioritization Committee **, Journal of the National Cancer Institute, 2017, PMID:28376230

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Comparative genomic expression signatures of signal transduction parhways and targets in paediatric Burkitt lymphoma: a Children's Oncology Group report

Lee S, Day NS, Miles RR, Perkins SL, Lim MS, Avello J, van de Ven C, Harrison L, El-Mallawany NK, Goldman S, Cairo MS, Br J Haemotol 177(): 601-611, 2017, PMID:28474336

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Poster presentation "Mass spectrometry-based proteomic profiling of Hodgkin lymphoma"

Wu R, Önder Ö, Rolland DCM, Elenitoba-Johnson KSJ, Lim MS, The International Symposium on Childhood, Adolescent and Young Adult Hodgkin Lymphoma, 2017

High incidence of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Older Adults with B-ALL.

Tasian SK, Hurtz C, Wertheim GB, Bailey NG, Lim MS, Harvey RC, I-Ming C, Willman CL, Astles R, Reshmi SC, Li MM, Frey NV, Luger SM, Carroll M, Perl AE, Leukemia 31(): 981-984, 2017, PMID:27932787

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NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma.

Murga-Zamalloa CA, Mondoza-Reinoso V, Sahasrabuddhe AA, Rolland DCM, Hwang SR, McDonnell SR, Scialis AP, Wilcox RA, Bashur V, Elenitoba-Johnson KSJ, Lim MS., Oncogene 36(): 2085-2094, 2017, PMID:27694894

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Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large dell lymphoma.

Hwang SR, Murga-Zamalloa C, Brown N, Basappa J, McDonnell SR, Mendoza-Reinoso V, Basrur V, Wilcox R, Elenitoba-Johnson KSJ, Lim MS,, Lab Invest, 2017, PMID:28414323

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Novel ALK fusion in a case of Anaplastic Large Cell Lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex.

Palacios G, Shaw T, Li Y, Singh RK, Valentine M, Sandlund JT, Lim MS, Mullighan CG, Leventaki V., Leukemia 3(): 743-747, 2017, PMID:27840423

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International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic Multicentric Castleman disease.

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Shanmuganathan C, Lechowicz MJ, Wong RSM, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel C, Casper C, Dispenzieri A, Fossa A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KSJ, Lim MS, Blood, 2017, PMID:28087540

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