Bryan L. Krock, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationThe Children's Hospital of Philadelphia
3615 Civic Center Boulevard, RM 706B ARC Bldg.
Philadelphia, PA, 19104
Office: 267-426-7588
Fax: 215-590-2156


BS (Biology), Pennsylvania State University, 2003
PhD (Biology), Texas A&M University, 2009

Specialty Certification

American Board of Medical Genetics and Genomics, 2015

Postgraduate Training

Research Assistant, Department of Biology, Texas A&M University, 2005-2009
Postdoctoral Fellow, Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 2009-2013
ABMG Clinical Molecular Genetics Fellow, University of Utah School of Medicine, Department of Pathology
ARUP Laboratories, Molecular Genetics and Genomics, 2013-2015

Awards and Honors

Knoll Scholarship, 1999-2003
Bayard D. and Ethel M. Kunkle Memorial Scholarship, 2000-2001
Texas A&M University Department of Biology Recruiting Weekend Poster Competition Winner, 2006
Texas A&M University Faculty of Neuroscience Spring Symposium Poster Contest, First Place., 2006
Texas and Southern Plains Zebrafish Conference Graduate Student Presentation Competition: First Place, 2007
Lawrence Dillon Distinguished Graduate Student Award (given to top Ph.D. candidate in the Biology Department), 2008
Individual Ruth F. Kirschstein F32 National Research Service award NRSA Award,, 2010
Roberts Memorial Fund Research Award, ARUP Laboratories,, 2014

Memberships and Professional Organizations

Association for Molecular Pathology Clinical Practice Committee., 2014 - 2015
American College of Medical Genetics and Genomics, 2016 - Present

Web Links

Selected Publications

Neurodevelopment Disorders Caused by De Novo Variants in KCNB1 Genotypes and Phenotypes

Carolien G. F. de Kovel, PhD1,2; Steffen Syrbe, MD, PhD3; Eva H. Brilstra, MD, PhD1; Nienke Verbeek, MD, PhD1; Bronwyn Kerr, PhD4,5,6; Holly Dubbs, MD7; Allan Bayat, MD, PhD8; Sonal Desai, MGC, CGC9; Sakkubai Naidu, MD10,11; Siddharth Srivastava, MD12; Hande Cagaylan, MD13; Uluc Yis, MD, PhD14; Carol Saunders, PhD15,16,17; Martin Rook, PhD18; Susanna Plugge, MSc19; Hiltrud Muhle, MD20; Zaid Afawi, MD, PhD21; Karl-Martin Klein, MD, PhD22; Vijayakumar Jayaraman, MSc23; Ramakrishnan Rajagopalan, PhD23; Ethan Goldberg, MD, PhD7; Eric Marsh, MD, PhD7; Sudha Kessler, MD, MSCE7; Christina Bergqvist, MD7; Laura K. Conlin, PhD23; Bryan L. Krock, PhD23; Isabelle Thiffault, PhD15,16; Manuela Pendziwiat, MSc20; Ingo Helbig, MD7,24; Tilman Polster, MD, PhD25; Ingo Borggraefe, MD, PhD26; Johannes R. Lemke, MD, PhD27; Marie-José van den Boogaardt, MD, PhD1; Rikke S. Møller, MSc, PhD8,28; Bobby P. C. Koeleman, PhD1, JAMA Neurology, 2017, PMID:28806457

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Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma

Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC, Radiology 283(3): 702-710, 2017, PMID:28253108

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Sequencing-based diagnostics for pediatric genetic diseases: progress and potential.

Abou Tayoun Ahmad N, Krock Bryan, Spinner Nancy B, Expert Rev Mol Diagn 17(): 1-13, 2016, PMID:27388938

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BRAT1-related disease-identification of a patient without early lethality

Mundy SA, Krock BL, Mao R, Shen JJ, Am J Med Genet A 170(3): 699-702, 2016, PMID:26494257

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Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration

Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM., Acta Neuropathol 130(3): 363-72, 2015, PMID:26022924

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Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

Viktor Lukacs, Jayani Mathur, Rong Mao, Pinar Bayrak-Toydemir, Melinda Procter, Stuart M. Calahan, Helen J. Kim, Michael Bandell, Nicola Longo, Ronald W. Day, David A Stevenson, Ardem Patapoutian, Bryan L. Krock, Nat Commun 6(): 8329, 2015, PMID:26387913

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The aryl hydrocarbon receptor nuclear translator is an essential regulator of murine hematopoietic stem cell viability

Krock BL, Eisinger-Mathason TS, Giannoukos DN, Shay JE, Gohil M, Lee DS, Nakazawa MS, Sesen J, Skuli N, Simon MC., Blood 125(21): 3263-72, 2015, PMID:25855602

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Neural tube defects and atypical deletion on 22q11.2.

Leoni Chiara, Stevenson David A, Geiersbach Katherine B, Paxton Christian N, Krock Bryan L, Mao Rong, Rope Alan F, American journal of medical genetics. Part A 164A(11): 2701-6, 2014, PMID:25123577

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The Par-PrkC polarity complex is required for cilia growth in zebrafish photoreceptors.

Krock Bryan L, Perkins Brian D, PloS One 9(8): e104661, 2014

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer.

Shay Jessica E S, Imtiyaz Hongxia Z, Sivanand Sharanya, Durham Amy C, Skuli Nicolas, Hsu Sarah, Mucaj Vera, Eisinger-Mathason T S Karin, Krock Bryan L, Giannoukos Dionysios N, Simon M Celeste, Carcinogenesis 35(5): 1067-77, 2014, PMID:24408928

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