Zheng Cai, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information252 John Morgan Building
36th St and Hamilton Walk
Philadelphia, PA 19104
Fax: 215-898-2401


Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

-protein production(E.Coli, Insect, Mammalian)
-protein structure determination (NMR/Crystallization)
-protein/protein, protein/ligand interaction, ITC, SPR, co-crytallization
-structure-based drug design and development.

-Kinase inhibitors, small molecule drugs
-antibody mimetics, peptide drugs

-Targeted therapies for ErbB and related receptors.
-Breast cancer, lung cancer, Colon Cancer
-Heparin-induced thrombocytopenia


B.S. (Biology), University of Sci. and Tech. of China , 1997
Ph.D. (Biochemistry and Molecular Biology), University of Sci. and Tech. of China , 2004

Specialty Certification

Postgraduate Training

Postdoctoral Researcher, Department of Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, 2005-2010

Awards and Honors

Memberships and Professional Organizations

American Association for Cancer Research - AACR, 2010 - 2011

Web Links

Selected Publications

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT)

Cai Z, Zhu Z, Greene MI, Cines DB, Autoimmun Rev 15(7): 752-5, 2016

Atomic description of the immune complex involved in heparin-induced thrombocytopenia.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, Greene MI*, Nature Communications, 2015

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT).

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, and Greene MI*., 56th ASH annual meeting, San Francisco, CA, 2014

Multi-crystal native SAD analysis at 6 keV.

Liu Q, Guo Y, Chang Y, Cai Z, Assur Z, Mancia F, Greene MI, Hendrickson WA., Acta Crystallogr D Biol Crystallogr 70(Pt 10): 2544-57, 2014

scFv-based "grababody" as a general strategy to improve recruitment of immune effector cells to antibody-targeted tumors.

Cai Z, Fu T, Nagai Y, Lam L, Yee M, Zhu Z and Zhang H, Cancer Research 73(8): 2619-27, 2013

Reversion of the ErbB malignant phenotype and the DNA damage response.

Runkle EA, Zhang H, Cai Z, Zhu Z, Karger BL, Wu SL, O'Rourke DM, Zhou Z, Wang Q, Greene MI, Experimental and molecular pathology 93(3): 324-33, 2012, PMID:23022358

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Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI, Cell reports 1(6): 665-75, 2012, PMID:22813742

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Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin.

Berezov A, Cai Z, Freudenberg J A, Zhang H, Cheng X, Thompson T, Murali R, Greene M I, Wang Q, Oncogene 31(15): 1938-48, 2012, PMID:21892210

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Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.

Zhou Z*, Du X*, Cai Z*, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R, Wu SL, Karger BL, Greene MI, Wang Q. (* co-first author), The Journal of biological chemistry 287(8): 5317-26, 2012, PMID:22170055

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Targeting erbB receptors.

Cai Z, Zhang H, Liu J, Berezov A, Murali R, Wang Q, Greene MI., Seminars in cell & developmental biology 21(9): 961-6, 2010, PMID:20850557

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