Jason N. Rosenbaum, MD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information3020 Market Street, Suite 220
Philadelphia, PA 19128
Office: 267-586-2525
Fax: 215-898-9817


Specialty Division

Precision and Computational Diagnostics

Itmat Expertise

Diagnostic and prognostic test design

Clinical Expertise

Molecular Diagnostics
Massively Parallel (Next-Generation) Sequencing
Molecular Biomarkers
Genomic Alterations in Lung Cancer
Neuroendocrine Neoplasms
Clinical Test Development and Validation


BA (Molecular and Cell Biology/Integrative Biology), University of California at Berkley, 1998
MD (Medicine), Northwestern University Feinberg School of Medicine, 2011

Specialty Certification

Certified by the American Board of Pathology in Anatomic and Clinical Pathology, 2015
Certified by the American Board of Pathology in Molecular Genetic Pathology, 2016

Postgraduate Training

Residency Training, Anatomic and Clinical Pathology, University of Wisconsin Hospital and Clinics, 2011-2015
Fellow, Molecular Genetic Pathology, Washington University, Barnes Jewish Hospital, 2015-2016

Awards and Honors

Chancellor's Scholar, University of California, Berkeley, 1994-1998
BA, High Honors, University of California, Berkeley, 1998
Morton Heller Award for Exemplary Research, 2010
Michael N. Hart Research Day Resident Presentation Award, University of Wisconsin, 2012
University of Wisconsin Research and Development Grant, 2012-2015
Best Poster Finalist, Education Category, American Society for Clinical
Pathology Annual Meeting, Chicago, IL, 2013
Quality Improvement Award, University of Wisconsin Hospital, 2013
Michael N. Hart Research Day Resident Presentation Award, University of Wisconsin, 2014
ICPI Travel Grant, USCAP Annual Meeting, San Diego, CA, 2014
Pilot Award, UWCCC Neuroendocrine Cancer Research Task Force and the Aly Wolff Memorial Fund for Neuroendocrine Carcinoma Research, 2015-2017
Trainee Research Day, Best Presentation Award, Washington University, 2016

Memberships and Professional Organizations

American Medical Association, 2001 - Present
American Association for the Advancement of Science, 2008 - 2010
Association for Molecular Pathology, 2011 - Present
Wisconsin Society of Pathology, 2011 - 2015
American Society for Clinical Pathology, 2011 - Present
College of American Pathologists, 2011 - Present
United States and Canadian Academy of Pathology, 2011 - Present
Endocrine Society, 2013 - Present
American Society of Human Genetics, 2014 - Present
Digital Pathology Association, 2014 - Present
American Society of Clinical Oncology, 2015 - Present
Wagih Bari Society of St. Louis Pathologists, 2015 - 2016
Pennsylvania State Medical Society, 2017 - Present
Pennsylvania Association of Pathologists, 2017 - Present

Web Links

Selected Publications

INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma).

P.S. Rush, J.N. Rosenbaum, R.M. Baus, D.D. Bennett, R.V. Lloyd. (2017), Journal of Cutaneous Pathology 45(2): 129-135, 2018, PMID:29148079

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Genomic Heterogeneity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer

J.N. Rosenbaum, R. Bloom, J.T. Forys, J. Hiken, J.R. Armstrong, J. Branson, S. McNulty, P.D. Velu, K. Pepin, H. Abel, C.E. Cotrell, J.D. Pfeifer, S. Kulkarni, R. Govindan, E.Q. Konnick, C.M. Lockwood, E.J. Duncavage, Modern Pathology, 2018, PMID:29327716

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Comparison of ALK, RET, and ROS1 Gene Fusion Detection by Next-Generation Sequencing, Fluorescence in situ Hybridization, and Immunohistochemistry in Non-Small Cell Lung Cancer.

A. Oran, J. Grubb, D.B. Lieberman, R.T. Sussman, J.J. Morrissette, J.N. Rosenbaum., Journal of Molecular Diagnostics 16(699): , 2017

Evaluation of Intraoperative Sampling for Genomic Analysis of Central Nervous System (CNS) Tumors by Next-Generation Sequencing (NGS)

R.T. Sussman, A. Viaene, P. Velu, S. Schaffer, J. Rosenbaum, J. Morrissette, M. Nasrallah, Journal of Molecular Diagnostics 16(699): , 2017

“Unburdening” Variant Review for High Tumor Mutation Burden (TMB) Cases in a Clinical Next-Generation Sequencing (NGS) Assay.

Orr, C, Morrissette, JD, Rosenbaum, JN., Journal of Molecular Diagnostics 16(699): , 2017

Discordance Among Biomarkers for Anti-PD1 Therapy Response: Tumor Mutational Burden and Anti-PD-L1 Staining

P.R. Hess, P.D. Velu, A. Bigdeli, J.J. Morrissette, J.N. Rosenbaum, J. Roth, Journal of Molecular Diagnostics 16(699): , 2017

Calculation of Mutational Burden in a Clinical Targeted Next-Generation Sequencing (NGS) Panel for Solid Tumors

P. Velu, A. Bigdeli, P.R. Hess, J.J. Roth, J.N. Rosenbaum, J.J. Morrissette, Journal of Molecular Diagnostics 16(699): , 2017

Evaluation of Copy Number Variation Detection Methods for Amplicon Sequencing Assays

A. Bigdeli, R. Sussman, A. Schrank-Hacker, V. Aikawa, J. Rosenbaum, J.D. Morrissette, R.B. Faryabi, Journal of Molecular Diagnostics 16(699): , 2017

Detection of MET Exon 14 Skipping in Non-Small Cell Lung Cancer (NSCLC) via RNA Anchored Multiplexed PCR and DNA Next-Generation Sequencing

C. Paolillo, A. Oran, J.N. Rosenbaum, J.J. Morrissette, R. Sussman., Journal of Molecular Diagnostics 16(699): , 2017

The Evolving Role of Companion Diagnostics for Breast Cancer in an Era of Next-Generation Omics

J.N. Rosenbaum, P. Weisman, The American Journal of Pathology 187(10): 2185, 2017, PMID:28733195

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