Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice

Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. J Exp Med. 2016 Oct 17. [Epub ahead of print] | doi: 10.1084/jem.20160833


A new study in the Journal of Experimental Medicine from the Lee Lab, "Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice," shows intracerebral inoculation of tau fibrils purified from AD brains (AD-tau), but not synthetic tau fibrils, resulted in the formation of abundant tau inclusions in anatomically connected brain regions in nontransgenic mice.
Read the Department of Communications news release.