Research at Penn

Translational and basic-science research in the Department of Pathology and Laboratory Medicine at Penn is conducted in many areas, including Autoimmunity and Allergy, Bioinformatics, Cancer Biology, Cardiovascular Pathobiology, Cell Biology and Signal Transduction, Developmental Mechanisms, Developmental, Stem Cell, & Regenerative Biology, Experimental Therapeutics, Gene Therapy and Vaccines, Genetics and Gene Regulation, HIV, Immune Health, Immunology, Immunotherapy, Microbiology, Neurodegenerative Diseases, Orphan Diseases, Proteomics, Recombination, Class Switching, DNA Repair.


Research Summary

The Department of Pathology and Laboratory Medicine hosts nationally and internationally recognized research programs covering diverse themes. Major focused strengths and scientific synergies have emerged within the Department in recent years. As part of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, the Department is consistently among the nation's top recipients of funding for biomedical research from the National Institutes of Health (NIH) and was ranked number one for awards in 2014. Department-wide research strengths include neurodegenerative diseases, immunobiology, cancer biology and therapeutics, cardiovascular pathobiology, and HIV immunology.

Research Initiatives

  • intracellular signaling
  • molecular mechanisms of leukemogenesis and sarcomagenesis, with special emphasis on aberrant transcriptional factors; RNA pathobiology
  • cellular development, such as lymphocyte, melanocyte, and bone development
  • endothelial cell and platelet pathobiology
  • metastasis and behavior of cells in situ and in three-dimensions
  • proteomics and protein modeling
  • emerging infectious diseases, including HIV
  • neurodegenerative mechanisms
  • experimental therapeutics