PUBLICATIONS

Faculty members regularly author or co-author publications in high-tiered journals and serve in editorial board positions. Here is a selection of representative Department faculty publications that have been highlighted in the news or otherwise garnered attention.


Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease

Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D; Parkinson’s Progression Markers Initiative (PPMI) PLoS One. 2017 May 17;12(5):e0175674. | doi: 10.1371/journal.pone.0175674. eCollection 2017.

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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Nature. 2017 May 10. doi: 10.1038/nature22075. [Epub ahead of print]

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Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent

Cruz-Roa A, Gilmore H, Basavanhally A, Feldman M, Ganesan S, Shih NNC, Tomaszewski J, González FA, Madabhushi A. Sci Rep. 2017 Apr 18;7:46450. doi: 10.1038/srep46450.

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Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients

Goldberg DS, Abt PL, Blumberg EA, Van Deerlin VM, Levine M, Reddy KR, Bloom RD, Nazarian SM, Sawinski D, Porrett P, Naji A, Hasz R, Suplee L, Trofe-Clark J, Sicilia A, McCauley M, Farooqi M, Gentile C, Smith J, Reese PP. N Engl J Med. 2017 Apr 30. doi: 10.1056/NEJMc1705221. [Epub ahead of print]

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Effect of a price transparency intervention in the electronic health record on clinician ordering of inpatient laboratory tests: The PRICE randomized clinical trial

Sedrak MS, Myers JS, Small DS, Nachamkin I, Ziemba JB, Murray D, Kurtzman GW, Zhu J, Wang W, Mincarelli D, Danoski D, Wells BP, Berns JS, Brennan PJ, Hanson CW, Dine CJ, Patel MS. JAMA Internal Medicine. 2017. Published online April 21 | doi:10.1001/jamainternmed.2017.1144

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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. Nature. 2017 Apr 10. doi: 10.1038/nature22079. [Epub ahead of print]

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International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe E, Elenitoba-Johnson KS, Lim MS. Blood. 2017 Jan 13. pii: blood-2016-10-746933. doi: 10.1182/blood-2016-10-746933. [Epub ahead of print]

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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. Lancet Neurol. 2017 Jan;16(1):55-65. doi: 10.1016/S1474-4422(16)30291-5.

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Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, Tsimberidou AM, Vnencak-Jones CL, Wolff DJ, Younes A1, Nikiforova MN. A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. J Mol Diagn. 2017 Jan;19(1):4-23. doi: 10.1016/j.jmoldx.2016.10.002.

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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, Vonderheide RH, Maity A, Wherry EJ, Minn AJ. Cell. 2016 Dec 1;167(6):1540-1554.e12. doi: 10.1016/j.cell.2016.11.022.

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Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice

Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. J Exp Med. 2016 Oct 17. [Epub ahead of print] | doi: 10.1084/jem.20160833

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Fox AJ, Hiemenz MC, Lieberman DB, Sukhadia S, Li B, Grubb J, Candrea P, Ganapathy K, Zhao J, Roth D, Alley E, Loren A, Morrissette JJ. J Vis Exp. 2016 Sep 20;(115). doi: 10.3791/52758.

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High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity

Doerner SK, Reiss ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH. Mol Cancer Res. 2016 Aug 17. pii: molcanres.0153.2016. [Epub ahead of print] | doi: 10.1158/1541-7786.MCR-16-0153

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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C8, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Nature. 2016 Aug 15. doi: 10.1038/nature19346. [Epub ahead of print]

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Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Cancer Cell. 2016 Jun 30. | doi: 10.1016/j.ccell.2016.06.001. [Epub ahead of print]

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Reengineering Chimeric Antigen Receptor T Cells for Targeted Therapy of Autoimmune Disease

Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, Di Zenzo G, Lanzavecchia A, Seykora JT, Cotsarelis G, Milone MC*, Payne AS*. Science. Jun 30 2016 Jul 1;353(6294):14. | doi: 10.1126/science.aaf6756 [Epub ahead of print]

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Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

Liu W, Yang R, Payne AS, Schowalter RM, Spurgeon ME, Lambert PF, Xu X, Buck CB, You J. Cell Host Microbe. 2016 May 18. pii: S1931-3128(16)30160-3. | doi: 10.1016/j.chom.2016.04.024. [Epub ahead of print]

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Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L. Nat Struct Mol Biol. 2016 Apr 25. | doi: 10.1038/nsmb.3211

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Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors

Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA. JAMA Oncol. 2016 Apr 14. | doi: 10.1001/jamaoncol.2016.0386. [Epub ahead of print]

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Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing

Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ. PLoS One. 2016 Apr 4;11(4):e0152851. doi: 10.1371/journal.pone.0152851.

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Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

Vourekas A, Alexiou P, Vrettos N, Maragkakis M, Mourelatos Z. Nature. 2016 Mar 7. doi: 10.1038/nature17150. [Epub ahead of print]
Unexpected function for piRNP complexes in mRNA trapping that may be generally relevant to the function of animal germ granules.
Read the Department of Communications post.

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RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L. Nat Commun. 2016 Feb 2;7:10529. | doi: 10.1038/ncomms10529

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Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G. J Clin Periodontol. 2016 Jan 5 | doi: 10.1111/jcpe.12507. [Epub ahead of print]

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Identification of fungal pathogens in a patient with acute myelogenic leukemia using a pathogen detection array technology

Banerjee S, Peck KN, Feldman MD, Schuster MG, Alwine JC, Robertson ES. Cancer Biol Ther. 2015 Nov 30. | doi: 10.1080/15384047.2015.1121349 [Epub ahead of print]

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Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience

Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C. Cancer Cytopathol. 2015 Dec 18. | doi: 10.1002/cncy.21666. [Epub ahead of print]

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