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Pilot Study Tests CAR T-Cell Immunotherapy in Glioblastomas

Science Translational Medicine reports results of phase 1 safety study of autologous CAR T cells targeted to EGFR variant III in glioblastoma patients.

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FDA Approval Recommendation for CAR T-Cell Therapy

FDA advisory committee unanimously approves first personalized cellular therapy developed at Penn for pediatric and young adult leukemia.

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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

A new Penn Medicine preclinical study in Cell, "Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade," suggests that an existing drug known as a JAK in

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Reengineering Chimeric Antigen Receptor T Cells for Targeted Therapy of Autoimmune Disease

In a Science study with potentially major implications for the future treatment of autoimmunity and related conditions, co-senior author

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Science Paper Describes Reengineered Chimeric Antigen Receptor T Cells for Targeted Therapy of Autoimmune Disease

Application could open up anti-cancer CAR approach to treatment for a much wider range of diseases, including autoimmunity and transplant rejection.

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Double Targeted CAR-T Scores in Preclinical Cancer Study for Solid Tumors

Paper in Immunity describes CAR T-Cells' effectiveness in mouse models of pancreatic cancer.

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