Carina A. Dehner, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of PennsylvaniaPerelman School of Medicine at the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
6 Founders Pavilion, Room 6.047
3400 Spruce St.
Philadelphia, PA 19104
Email: carina.dehner@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Clinical Expertise
Bone & Soft Tissue Pathology
Dermatopathology
Rhabdomyosarcoma
NF1-associated neoplasms including malignant peripheral nerve sheath tumors
Fusion-driven mesenchymal neoplasms
Pemphigus Vulgaris
Cutaneous mesenchymal tumors
Research Expertise
Molecular drivers of neurofibromatous neoplasms, including malignant peripheral nerve sheath tumors (MPNST) and adult-type rhabdomyosarcomas (RMS)
Cutaneous mesenchymal neoplasms
Melanocytic tumors
Graduate Groups
Immunology
Education
MD PhD Technical University Munich, 2016
Specialty Certification
Anatomic Pathology, American Board of Pathology, 2021
Dermatopathology, American Board of Pathology, 2022
Postgraduate Training
Postdoctoral Fellow, Yale University, 2016-18
Resident, Anatomic Pathology, Washington University in St. Louis, 2018-21
Fellow, Dermatopathology, Washington University in St. Louis, 2021-22
Fellow, Bone & Soft Tissue Pathology, Mayo Clinic in Rochester, MN, 2022-23
Awards and Honors
ASIP (American Society of Investigative Pathology) EPIGT Merit Award, 2015
Young Research Investigator of the LMU at the Lindau Nobel Laureate Meeting 2015
Invited Oral Speaker in Prof. Peter C. Doherty’s Master Class, 2015
AAI (American Association of Immunology) Trainee Abstract Award, 2015
ASIP Poster Merit Award at the PISA meeting in Houston, 2015
ASIP Trainee Travel Award for the PISA meeting, 2015 & 2016
FOCIS 2017 Clinical Immunology Trainee Award, 2017
ASIP Sobel Award for the Experimental Biology meeting in Chicago, 2017
FOCIS FCE Fusion Poster of Excellence Award, 2017
ISCL Young Investigator Award from the Cutaneous Lymphoma Foundation, 2018
Stowell Orbinson Award (USCAP), 2019
Best AP Oral Presentation, Trainee Research Day, Washington University in St. Louis, 2022
Fellow Educator of the Year, Washington University in St. Louis, 2021-22
Memberships and Professional Organizations
United States and Canadian Academy of Pathology (USCAP), 2018-present
-------- Resident Advisory Committee, 2024-present
International Society of Bone and Soft Tissue Pathology (ISBST), 2019-present
American Society of Dermatopathology (ASDP), 2019-present
-------- Fellow In-Service Assessment Committee, 2022-23
-------- Young Physicians Committee, 2023-25
European Society of Pathology, 2022-present
International Skeletal Society, 2025-present
Web Links
(twitter) @carina_dehner
@acetylcholine88
Selected Publications
CD34-Positive Acral Chondromyxoid Mesenchymal Neoplasm Harboring a Novel TCF4::ERG Fusion
Honaker EC, Warmke LM, Baptiste A, Baumhoer D, Baranov E, Halper-Stromberg E, Dehner CA. Genes Chromosomes Cancer 64(8):e70073, Jul 2025. doi: 10.1002/gcc.70073. PMID: 40878874; PMCID: PMC12340472.
Beyond Hybrid Morphology: A Large Series of Fusion-Driven Benign Peripheral Nerve Sheath Tumors Including 5 Tumors With Novel Fusions
Dehner CA, Platero-Portillo T, Jour G, Saoud C, Zhang Y, Buehler D, Hameed M, Michal M, Kerr D, Busam KJ, Agaimy A, Torres-Mora J, Antonescu CR, Linos K. Mod Pathol 38(10):100806, Jun 2025. doi: 10.1016/j.modpat.2025.100806. Epub ahead of print. Erratum in: Mod Pathol. 2025 Jul 26;38(9):100839. doi: 10.1016/j.modpat.2025.100839. PMID: 40484320.
ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case
Dehner CA, Pissaloux D, Thamphya B, Tirode F, Von Deimling A, Guo RR, Wieland C, de la Fouchardière A, Kervarrec T. Virchows Arch 486(4): 871-875, 2025. PMID:39847051.
Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1
Lucas CG, Gross AM, Romo CG, Dehner CA, Lazar AJ, Miettinen M, Pekmezci M, Quezado M, Rodriguez FJ, Stemmer-Rachamimov A, Viskochil D, Perry A, Symposium on Atypical Neurofibroma: State of the Science Members. Neuro Oncol 27(3): 616-624, 2025. PMID:39500722
Genomic and Transcriptomic Characterization of Protein Kinase C Fusion Melanocytic Neoplasms With Distinctive Hypopigmented Histomorphology: A Single-Institution Study
Li A, Umphress B, Dehner C, Jones R, Toral K, Warren S, Alomari AK. J Cutan Pathol, 2025. PMID:40109002.
Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1-rearranged porocarcinoma
Legrand M, Louveau B, Osio A, Tallet A, Calonje E, Scoazec JY, de la Fouchardiere A, Tirode F, Von Deimling A, Busam K, Shah A, Flaman A, Jouenne F, Mourah S, Pissaloux D, Lantuejoul S, French CA, Goto K, Cribier B, Dehner CA, Alomari AK, Fletcher CD, Hanna J, Macagno N, Battistella M, Kervarrec T. Histopathology 2025. PMID:40125640.
Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma?
Dehner CA, Jour G, Gassenmaier M, Michal M, de Saint Aubain N, Papke DJ Jr, Umphress B, Li A, Tanner MM, Calonje E, Brenn T, Fletcher CDM, Mentzel T, Busam K, Linos K. Am J Surg Pathol 2025. PMID:40070162.
Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations
Toklu A, Panse G, Jour G, Linos K, Cloutier JM, Dehner CA. Virchows Arch, 2025. PMID:40159563.
YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma
Warmke LM, Ameline B, Fritchie KJ, Dehner CA, Agaimy A, Din NU, Miettinen MM, Dermawan JK, Gross JM, Thangaiah JJ, Chrisinger JSA, Suster DI, Perret R, Le Loarer F, Charville GW, Buehler D, Yeung MCF, Smith BF, Baumhoer D, Davis JL. Virchows Arch 486(3): 457-477, 2025. PMID:39641785.
Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity
Dehner CA, Warmke LM, Umphress B, Malik F, Cloutier JM, Dermawan JK, Fritz M, Que SKT, Ameline B, Fritchie KJ, Kerr DA, Linos K, Baumhoer D, Billings SD, Folpe AL. Mod Pathol 38(2): 100656, 2025. PMID:39522640.
