Hongtao Zhang, PhD
Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact InformationDepartment of Pathology and Laboratory Medicine
252 John Morgan Bldg
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401
Email: zhanghon@pennmedicine.upenn.edu
Specialty Division
Immunobiology and Experimental Pathology
Research Expertise
Targeted therapies for ErbB and related receptors (EGFR, HER2)
Inhibitors for TNF family of receptors: TNFR, RANK etc.
Protein engineering for antibody -like proteins
Biomarkers to facilitate treatment for Breast cancer and Melanoma
Itmat Expertise
Targeted therapies for cancers
Immune modulation with cytokines
Serum biomarkers for cancers
Protein engineering
Education
B.S. (Biochemistry), Beijing University, China, 1991
M.S. (Molecular Biology), Beijing University, China, 1994
Ph.D (Pharmacology), University of Pennsylvania, 1998
Specialty Certification
Postgraduate Training
Post-doc, University of Pennsylvania, 1998-2001
Awards and Honors
Memberships and Professional Organizations
American Association for Cancer Research, 1997 - 1999
Sino-American Pharmaceutical Professionals Association Greater Philadelphia Chapter, 2005 - 2007
The Antibody Society, 2007 - Present
Congressionally Directed Medical Research Programs(CDMRP), US Army, 2012 - Present
Congressionally Directed Medical Research Programs(CDMRP), US Army, 2013 - Present
Selected Publications
Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation
Kumar, S. M., Liu, S., Lu, H., Zhang, H., Zhang, P. J., Gimotty, P. A., Guerra, M., Guo, W., Xu, X., Oncogene 31(47): 4898-911, 2012, PMID:22286766
Structural and Biological features of Insights of FOXP3 Dimerization Relevent to Regulatory T Cell Function. Coiled Coil Subdomain in Oligomerization-Dependent Immune Modulation
Song, X., Li, B., Xiao, Y., Chen, C., Wang, Q., Liu, Y., Berezov, A., Xu, C., Gao, Y., Li, Z., Wu, S., Cai, Z., Zhang, H., Karger, B., Hancock, W.H., Wells, A. D., Zhou, Z. and Greene, M.I., Cell reports 1(6): 665-75, 2012
Mesothelin, a novel immunotherapy target for triple negative breast cancer.
Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ., Breast Cancer Res Treat. 133(2): 799-804, 2012
Challenges in the clinical utility of the serum test for HER2 ECD
Lam, L., McAndrew, N., Yee, M., Fu, T., Tchou, J.C., and Zhang, H., Biochimica et biophysica acta 1826(1): 199-208, 2012
Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope
Zhou, Z., Du, X., Cai, Z., Song, X., Zhang, H., Mizuno, T., Suzuki, E., Yee, M. R., Berezov, A., Murali, R., Wu, S. L., Karger, B. L., Greene, M. I., Wang, Q., The Journal of biological chemistry 287(8): 5317-26, 2012, PMID:22170055
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity
Zhang, H., Xiao, Y., Zhu, Z., Li, B., Greene, M. I., Immunol Cell Biol 90(1): 95-100, 2012
Structural insights into the down-regulation of overexpressed p185her2/neu of transformed cells by the antibody chA21
Zhou, H., Zha, Z., Liu, Y., Zhang, H., Zhu, J., Hu, S., Cheng, L., Niu, L., Greene, M.I. , Teng, M. and Liu, J., JBC 286(36): 31676-83, 2011
Progress of molecular targeted therapies for prostate cancers
Fu, W., Madan, E., Yee, M., Zhang, H., Biochimica et biophysica acta 1825(2): 140-152, 2011
IL8 and Cathepsin B as Melanoma Serum Biomarkers.
Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, and Xu X., Int j Mol Sci 12(3): 1505-1518, 2011, PMID:21673904
