Hongtao Zhang, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
252 John Morgan Bldg
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401


Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

Targeted therapies for ErbB and related receptors (EGFR, HER2)
Inhibitors for TNF family of receptors: TNFR, RANK etc.
Protein engineering for antibody -like proteins
Biomarkers to facilitate treatment for Breast cancer and Melanoma

Itmat Expertise

Targeted therapies for cancers
Immune modulation with cytokines
Serum biomarkers for cancers
Protein engineering


B.S. (Biochemistry), Beijing University, China, 1991
M.S. (Molecular Biology), Beijing University, China, 1994
Ph.D (Pharmacology), University of Pennsylvania, 1998

Specialty Certification

Postgraduate Training

Post-doc, University of Pennsylvania, 1998-2001

Awards and Honors

Memberships and Professional Organizations

American Association for Cancer Research, 1997 - 1999
Sino-American Pharmaceutical Professionals Association Greater Philadelphia Chapter, 2005 - 2007
The Antibody Society, 2007 - Present
Congressionally Directed Medical Research Programs(CDMRP), US Army, 2012 - Present
Congressionally Directed Medical Research Programs(CDMRP), US Army, 2013 - Present

Selected Publications

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

Kumar, S. M., Liu, S., Lu, H., Zhang, H., Zhang, P. J., Gimotty, P. A., Guerra, M., Guo, W., Xu, X., Oncogene 31(47): 4898-911, 2012, PMID:22286766

Read article

Structural and Biological features of Insights of FOXP3 Dimerization Relevent to Regulatory T Cell Function. Coiled Coil Subdomain in Oligomerization-Dependent Immune Modulation

Song, X., Li, B., Xiao, Y., Chen, C., Wang, Q., Liu, Y., Berezov, A., Xu, C., Gao, Y., Li, Z., Wu, S., Cai, Z., Zhang, H., Karger, B., Hancock, W.H., Wells, A. D., Zhou, Z. and Greene, M.I., Cell reports 1(6): 665-75, 2012

Mesothelin, a novel immunotherapy target for triple negative breast cancer.

Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ., Breast Cancer Res Treat. 133(2): 799-804, 2012

Challenges in the clinical utility of the serum test for HER2 ECD

Lam, L., McAndrew, N., Yee, M., Fu, T., Tchou, J.C., and Zhang, H., Biochimica et biophysica acta 1826(1): 199-208, 2012

Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope

Zhou, Z., Du, X., Cai, Z., Song, X., Zhang, H., Mizuno, T., Suzuki, E., Yee, M. R., Berezov, A., Murali, R., Wu, S. L., Karger, B. L., Greene, M. I., Wang, Q., The Journal of biological chemistry 287(8): 5317-26, 2012, PMID:22170055

Read article

Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity

Zhang, H., Xiao, Y., Zhu, Z., Li, B., Greene, M. I., Immunol Cell Biol 90(1): 95-100, 2012

Structural insights into the down-regulation of overexpressed p185her2/neu of transformed cells by the antibody chA21

Zhou, H., Zha, Z., Liu, Y., Zhang, H., Zhu, J., Hu, S., Cheng, L., Niu, L., Greene, M.I. , Teng, M. and Liu, J., JBC 286(36): 31676-83, 2011

Progress of molecular targeted therapies for prostate cancers

Fu, W., Madan, E., Yee, M., Zhang, H., Biochimica et biophysica acta 1825(2): 140-152, 2011

IL8 and Cathepsin B as Melanoma Serum Biomarkers.

Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, and Xu X., Int j Mol Sci 12(3): 1505-1518, 2011, PMID:21673904

Read article