Megan S. Lim, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine
Director, Hematopathology

Contact InformationDepartment of Pathology and Laboratory Medicine
Stellar Chance Office Suite 609C
422 Curie Blvd.

Philadelphia, PA, 19104
Office: 215-898-4719
Fax: 215-898-9969


Specialty Division


Itmat Expertise

hematologic cancer
molecular pathogenesis
genomic analysis
mass spectrometry driven proteomics


BS (Cell and Microbiology), University of Calgary, 1983
MS (Biochemistry, Cell Regulation Group, Department of Medical Biochemistry, Faculty of Medicine), University of Calgary, 1985
MD (Medicine), University of Calgary, 1988
PhD (Molecular Oncology), University of Calgary joint with National Cancer Institute, National Institute of Health, 1999

Specialty Certification

Licentiate of Medical Council of Canada (LMCC), 1988
Fellow, Royal College of Physicians and Surgeons of Canada (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Anatomic Pathology), 1993
Diplomate of American Board of Pathology (Hematology), 1999
Diplomate of American Board of Pathology (Molecular Genetic Pathology), 2003

Postgraduate Training

Residency in Anatomic Pathology, University of Calgary (Calgary, Alberta), 1988-1993
Chief Resident, Pathology Training Program, Foothills Hospital (Calgary, Alberta), 1991-1991
Research Fellowship, Cancer Research Group, Faculty of Medicine, University of Calgary (Calgary, Alberta), 1993-1995
Fellowship, Hematopathology, Lab of Pathology, National Cancer Institute, National Institutes of Health, (Bethesda, MD), 1995-1998
Mid-Career Women Faculty Professional Development Seminar, Association of American Medical Colleges (Washington, DC), 2003-2003
Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health (Boston, MA), 2012-2012

Awards and Honors

Faculty of Science Dean’s List, University of Calgary, 1982
Louise McKinney Scholarship for Outstanding Academic Achievement, University of Calgary, 1982
Alberta Heritage Foundation for Medical Research Summer Studentship, 1983
Alberta Heritage Foundation for Medical Research Studentship, 1983-1985
Alberta Heritage Foundation for Medical Research Part-Time Studentship (while in MD program), 1985-1987
Nominated by Medical Research Council of Canada for the Royal Society of Canada’s Women in Scholarship Alice Wilson Award, 1993
Fee Scholarship Award, Faculty of Graduate Studies, University of Calgary, 1994-1997
National Institutes of Health Fogarty Visiting Fellowship, 1996-1998
Junior Scientist Award, Canadian Association of Pathology, 2000
Young Investigator Award, Children’s Oncology Group, 2002
Translational Research Award, Children’s Oncology Group, 2004
Best Doctors of America, 2005-2014
Pluto Society, 2015
Abstract Achievement Award, American Society of Hematology, 2019-2019

Memberships and Professional Organizations

Canadian Medical Association, 1985 - 1993
Canadian Association of Pathologists, 1988 - 2017
Royal College of Physicians and Surgeons of Canada, 1993 - 2017
Canadian Medical Protective Association, 1993 - 2000
American Association for Cancer Research, 1994 - Present
Society for Hematopathology/European Association for Haemotopathology, 1995 - Present
American Society of Hematology, 1995 - Present
United States and Canadian Academy of Pathology, 1996 - Present
American Association for the Advancement of Science, 1997 - 1999
College of Physicians and Surgeons of Ontario, 1998 - 2003
Association for Molecular Pathology, 1998 - Present
European Society of Hematopathology, 1998 - 2016
Canadian Hematology Society, 1999 - 2001
American Society of Investigative Pathology, 2002 - Present
Children’s Oncology Group, 2002 - Present
American Biologic Resources and Facilities, 2005 - 2007
National Institutes of Health, 2005 - Present
American Society of Mass Spectrometry, 2006 - 2006
Michigan Society of Pathologists, 2007 - 2015
A. J. French Society, 2007 - 2015
College of American Pathologists, 2008 - Present
American Society for Clinical Pathology, 2008 - 2012
American Society of Clinical Pathology, 2008 - Present
United States Cutaneous Lymphoma Consortium, 2014 - 2014
American Association of University Pathologists - Pluto Society (elected member), 2015 - Present
University of Michigan, 2016 - 2016
Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Peer Review Cancer Research Program (PRCRP) - Lymphoma (LYM), 2016 - 2019
Ontario Genomics; Grant Review - Genome Canada, Large-Scale Applied Research Project on Genomics in Precision Health., 2017 - 2017
National Science Center, Poland, 2017 - 2017
National Institutes of Health, Lymphoma and Leukemia Molecular Profiling Project Grant, 2019 - 2024
Medical Research Council of United Kingdom, 2020 - 2020
Leukemia and Lymphoma Society of Canada, 2022 - Present

Web Links

Selected Publications

Bone Marrow Findings of Idiopathic Multicentric Castleman Disease: A Histopathologic Analysis and Systematic Literature Review.

Belyaeva E, Rubenstein A, Pierson SK, Dalldorf D, Frank D, Lim MS, Fajgenbaum DC, Hematol Oncol, 2022, PMID:35104370

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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.

Zelenetz AD, Gordon LI, Chang JE, Christian B, Abramson JS, Advani RH, Bartlett NL, Budde LE, Caimi PF, De Vos S, Dholaria B, Fakhri B, Fayad LE, Glenn MJ, Habermann TM, Hernandez-Ilizaliturri F, Hsi E, Hu B, Kaminski MS, Kelsey CR, Khan N, Krivacic S, LaCasce AS, Lim M, Narkhede M, Rabinovitch R, Ramakrishnan P, Reid E, Roberts KB, Saeed H, Smith SD, Svoboda J, Swinnen LJ, Tuscano J, Vose JM, Dwyer MA, Sundar H. J, J Natl Compr Canc Netw 19(11): 1218-1230, 2021, PMID:34781267

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Brentuximab vendotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas.

Svoboda J, Bair SM, Landsburg DJ, Dwivedy Nasta S, Nagle SJ, Barta SK, Khan N, Filicko-O’Hara J, Gaballa S, Strelec L, Chong E, Mitnick S, Waite TS, King C, Ballard H, Youngman M, Gerson J, Plastaras JP, Maity A, Bogusz AM Hung SS, Nakamura H, Nejati R, Steidl C, Lim M, Ruella M, Schuster SJ., Heamatologica 106(6): 1705-1713, 2021, PMID:32414850

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Brentuximab Vedotin in Combination with Chemotherapy for Pediatric Patients with ALK+ALCL: Results of COG Trial ANHL12P1.

Lowe EJ, Reilly AF, Lim MS, Gross TG, Saguilig L, Barkauskas DA, Wu R, Alexander S, Bollard CM., Blood, 2021, PMID:33684925

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The WHO Classification of Tumours, 5th Edition

WHO Classification of Tumours Editorial Board: E. Campo, N. L. Harris, E. S. Jaffe, S. A. Pileri, H. Stein, J. Thiele, D. Arber, R. Hasserjian, M. Le, International Agency for Research on Cancer, 2021

Multicentric Castleman disease [maybe move under HHV8+ DLBCL; Anaplastic large cell lymphoma, ALK positive; Anaplastic large cell lymphoma, ALK negative.

Lim MS, WHO Classification of Tumours, 5th edition-Haematolymphoid Tumours, 2021

ACCELERATE: A patient-powered natural history study design enabling clinical and therapeutic discoveries in a rare disorder

Pierson SK, Khor JS, Ziglar J, Liu A, Floess K, NaPier E, Gorzewski AM, Tamakloe MA, Powers V, Akhter F, Haljasmaa E, Jayanthan R, Rubenstein A, Repasky M, Elenitoba-Johnson KSJ, Ruth J, Jacobs B, Streetly M, Angenendt L, Patier JL, Ferrero S, Zinzani PL, Terriou L, Casper C, Jaffe E, Hoffman C, Oksenhendler E, Fosså A, Srkalovic G, Chadburn A, Uldrick TS, Lim M, van Rhee F, Fajgenbaum DC, Cell Rep Med 1(99): , 2020, PMID:33377129

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International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease

van Rhee F, Oksenhendler E, Srkalovic G, Voorhees P, Lim M, Dispenzieri A, Ide M, Parente S, Schey S, Streetly M, Wong R, Wu D, Maillard I, Brandstadter J, Munshi N, Bowne W, Elenitoba-Johnson KSJ, Fossä A, Lechowicz MJ, Chandrakasan S, Pierson SK, Greenway A, Nasta S, Yoshizaki K, Kurzrock R, Uldrick TS, Casper C, Chadburn A, Fajgenbaum DC, Blood Adv 4(23): 6039-50, 2020, PMID:33284946

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Mastermind: A comprehensive genomic association search engine for empirical evidence curation and genetic variant interpretation.

Chunn LM, Nefcy DC, Ritter RW, Tarpey RP, Chuahan G, Lim MS, Elenitoba-Johnson KSJ, Schwartz SA and Kiel MJ., Front Genet. 11(): , 2020, PMID:32894785

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Insufficient evidence exists to use histopathologic subtype to guide treatment of idiopathic multicentric Castleman disease.

Fajgenbaum DC, Wu D, Goodman A, Wong R, Chadburn A, Nasta S, Srkalovic G, Mukherjee S, Leitch H, Jayanthan R, Ferrero S, Sato Y, Schey S, Dispenzieri A, Oksenhendler E, Zinzani PL, Lechowicz MJ, Hoffman C, Pemmaraju N, Bagg A, Fossa A, Lim MS, van Rhee F., Am J Hematol, 2020, PMID:32894785

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