Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma. A collaborative effort between the Pear Lab at the University of Pennsylvania and researchers at the Harvard Medical School sheds new light into how Notch drives the growth of B-cell cancers. The teams report their findings, "A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas," in Cell Reports.
Read the Department of Communications news release