PEOPLE

Yuk Yee Leung, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania

Philadelphia, PA, 19104

Clinical Expertise

small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases

translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases



 

Research Expertise

Machine Learning
Data Mining
Statistics
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis

Itmat Expertise

Biomarker Discovery
RNAs
Small RNAs
Bioinformatics

Education

BEng(MedE) University of Hong Kong, 2005
PhD University of Hong Kong, 2010

Specialty Certification

Postgraduate Training

Postdoctoral Researcher , Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 2010-2015

Awards and Honors

Memberships and Professional Organizations

IEEE Engineering in Medicine & Biology Society, 2005 - 2009
American Society of Human Genetics, 2014 - 2015
American Society of Human Genetics, 2015 - Present

Web Links


Selected Publications

In silico identification of RNA modifications from high-throughput sequencing data using HAMR.

Kuksa P.P., Leung Y.Y., Vandivier L., Anderson Z., Gregory B. D. and Wang L.-S., RNA Methylation: Methods and Protocols 1562(): 211-229, 2017

NIAGADS: The NIA Genetics of Alzheimer's Disease Data Storage Site.

Partch A., Valladares O., Cweibel R., Greenfest-Allen E., Childress M., Malamon J., Gangadharan P., Zhao Y., Qu L., Leung Y.Y., Naj A.C., Stoeckert, Jr. C.J., Schellenberg G.D. and Wang L.-S., Alzheimer’s and Dementia 12(11): 1200–1203, 2016

Partch A., Valladares O., Cweibel R., Greenfest-Allen E., Childress M., Malamon J., Gangadharan P., Zhao Y., Qu L., Leung Y.Y., Naj A.C., Stoeckert, Jr. C.J., Schellenberg G.D. and Wang L.-S.

NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)., 66th Annual Meeting of the American Society of Human Genetics, Vancouver, British Columbia, Canada., 2016

INFERNO – INFERring the molecular mechanisms of NOncoding genetic variants.

Amlie-Wolf A., Tang M., Kuksa P.P., Leung Y.Y., Slaff B., King J., Dombroski B., Schellenberg G.D., and Wang L.-S., 66th Annual Meeting of the American Society of Human Genetics, Vancouver, British Columbia, Canada., 2016

The landscape of regulatory post-transcriptionally derived small noncoding RNAs in the human transcriptome.

Leung Y.Y., Kuksa P.P., Amlie-Wolf A., and Wang L.-S., 66th Annual Meeting of the American Society of Human Genetics, Vancouver, British Columbia, Canada., 2016

Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence.

Crowe E.P., Tuzer F., Gregory B.D., Donahue G., Gosai S.J., Leung Y.Y., Yetkin E., Cohen J., Nativio R., Wang L.-S., Sell C., Bonini N.M., Berger S.L., Johnson F.B. and Torres C., Frontiers in Aging Neuroscience 8(): 208, 2016, PMID:27630559

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DASHR - Database of small human noncoding RNA.

Leung Y.Y.*, Kuksa P.P*. Amlie-Wolf A., Valladares O., Ungar L.H., Kannan S., Gregory B.D. and Wang L.S., Nucleic Acids Research 44(D1): D216-D222, 2016, PMID:26553799

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DASHR - Database of small human noncoding RNA.

Leung Y.Y., Kuksa P.P. Amlie-Wolf A., Valladares O., Gregory B.D. and Wang L.S., 65th Annual Meeting of the American Society of Human Genetics, Baltimore, Maryland, USA., 2015

SPARS: Sequencing-based pipeline for annotating novel small non-coding RNAs.

Kuksa P.P., Leung Y.Y., Amlie-Wolf A., Gregory B.D. and Wang L.S., 65th Annual Meeting of the American Society of Human Genetics, Baltimore, Maryland, USA., 2015

Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study.

Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative., Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015, PMID:26693175

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