PEOPLE

Yuk Yee Leung, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania

Philadelphia, PA, 19104

Email: yyee@pennmedicine.upenn.edu

Clinical Expertise

Small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases
Translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases

Research Expertise

Machine Learning
Data Mining
Statistics
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis

Itmat Expertise

Biomarker Discovery
RNAs
Small RNAs
Bioinformatics

Education

BEng (Medical Engineering ), University of Hong Kong, 2005
PhD (Electrical and Electronic Engineering (Bioinformatics)), University of Hong Kong, 2010

Specialty Certification

Postgraduate Training

Postdoctoral Researcher , Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 2010-2015

Awards and Honors

Memberships and Professional Organizations

IEEE Engineering in Medicine & Biology Society, 2005 - 2009
American Society of Human Genetics, 2014 - 2015
American Society of Human Genetics, 2015 - Present
Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 - Present

Web Links


Selected Publications

Inferring the molecular mechanisms of noncoding Alzheimer's disease-associated genetic variants

Alexandre Amlie-Wolf, Mitchell Tang, Jessica Way, Beth Dombroski, Ming Jiang, Nicholas Vrettos, Yi-Fan Chou, Yi Zhao, Amanda Kuzma, Elisabeth E. Mlynarski, Yuk Yee Leung, Christopher D. Brown, Li-San Wang, Gerard D. Schellenberg, Journal of Alzheimer's Disease, 2019, PMID:31561366

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Functional Annotation of genomic variants in studies of Late-Onset Alzheimer’s Disease.

Butkiewicz M, Blue E, Leung YY, Jian X, Marcora E, Renton A, Kuzma A, Wang L-S, Koboldt D, Haines JL, Bush WS, Bioinformatics, 2018, PMID:29590295

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VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.

Leung YY, Valladares O, Chou Y-F, Lin H-J, Kuzma A, Cantwell L, Qu L, Gangadharan P, Alzheimers Disease Sequencing Project (ADSP), Salerno W.J., Schellenberg G.D., Wang L-S., Bioinformatics, 2018, PMID:30351394

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SPAR: Small RNA-seq Portal for Analysis of sequencing expeRiments

Kuksa PP, Amlie-Wolf A, Katanic Z, Valladares O, Wang LS, Leung YY, Nucleic Acids Research WebServer Issue, 2018, PMID:29733404

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DASHR 2.0: integrated database of human small non-coding RNA genes and mature products

Pavel P Kuksa, Alexandre Amlie-Wolf, Živadin Katanić, Otto Valladares, Li-San Wang, Yuk Yee Leung, Bioinformatics, 2018, PMID:30668832

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NIAGADS: The NIA Genetics of Alzheimer's Disease Data Storage Site.

Partch A., Valladares O., Cweibel R., Greenfest-Allen E., Childress M., Malamon J., Gangadharan P., Zhao Y., Qu L., Leung Y.Y., Naj A.C., Stoeckert, Jr. C.J., Schellenberg G.D. and Wang L.-S., Alzheimer's & Dementia: The Journal of the Alzheimer's Association 12(11): 1200–1203, 2016, PMID:29795290

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Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study.

Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative., Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015, PMID:26693175

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Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence.

Crowe E.P., Tuzer F., Gregory B.D., Donahue G., Gosai S.J., Leung Y.Y., Yetkin E., Cohen J., Nativio R., Wang L.-S., Sell C., Bonini N.M., Berger S.L., Johnson F.B. and Torres C., Frontiers in Aging Neuroscience 8(): 208, 2016, PMID:27630559

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CoRAL: Predicting non-coding RNAs from small RNA-sequencing data.

Leung Y.Y.*, Ryvkin P.*, Gregory B. and Wang L.S., Nucleic Acids Research 41(14): e137, 2013, PMID:23700308

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Using machine learning and high-throughput RNA sequencing to characterize small non-coding RNAs.

Ryvkin P.*, Leung Y.Y.*, Unger L.H., Gregory B.D. and Wang L.S., Methods 67(1): 28-35, 2013, PMID:24145223

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