Yuk Yee Leung, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania

Philadelphia, PA, 19104

Clinical Expertise

small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases

translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases


Research Expertise

Machine Learning
Data Mining
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis

Itmat Expertise

Biomarker Discovery
Small RNAs


BEng(MedE) University of Hong Kong, 2005
PhD University of Hong Kong, 2010

Specialty Certification

Postgraduate Training

Postdoctoral Researcher , Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 2010-2015

Awards and Honors

Memberships and Professional Organizations

IEEE Engineering in Medicine & Biology Society, 2005 - 2009
American Society of Human Genetics, 2014 - 2015
American Society of Human Genetics, 2015 - Present
Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 - Present

Web Links

Selected Publications

DASHR - Database of small human noncoding RNA.

Leung Y.Y.*, Kuksa P.P*. Amlie-Wolf A., Valladares O., Ungar L.H., Kannan S., Gregory B.D. and Wang L.S., Nucleic Acids Research 44(D1): D216-D222, 2016, PMID:26553799

Read article

CoRAL: Predicting non-coding RNAs from small RNA-sequencing data.

Leung Y.Y.*, Ryvkin P.*, Gregory B. and Wang L.S., Nucleic Acids Research 41(14): e137, 2013, PMID:23700308

Read article

HAMR: High throughput Annotation of Modified Ribonucleotides.

Ryvkin P.*, Leung Y.Y.*, Silverman I.M.*, Childress M., Valladares O., Dragomir I., Gregory B.D. and Wang L.S., RNA 19(12): 1684-92, 2013, PMID:24149843

Read article

Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study.

Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative., Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015, PMID:26693175

Read article

NIAGADS: The NIA Genetics of Alzheimer's Disease Data Storage Site.

Partch A., Valladares O., Cweibel R., Greenfest-Allen E., Childress M., Malamon J., Gangadharan P., Zhao Y., Qu L., Leung Y.Y., Naj A.C., Stoeckert, Jr. C.J., Schellenberg G.D. and Wang L.-S., Alzheimer’s and Dementia 12(11): 1200–1203, 2016

Plasma Biomarkers of Depressive Symptoms in Older Adults.

Arnold S.E., Xie S.X., Leung Y.Y., Wang L.S., Kling M.A., Han X., Kim E., Wolk D.A., Bennett D.A., Chen-Plotkin A., Grossman M., Hu W., Lee V.M.-Y., Mackin S., Trojanowski J.Q., Wilson R.S., Shaw L.M. and Alzheimer's Disease Neuroimaging Initiative, Translational Psychiatry 2(): e65, 2012, PMID:22832727

Read article

Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease

Wang L.S., Leung Y.Y., Chang S.K., Leight S., Knapik-Czajka M., Baek Y., Shaw L.M., Lee V.M., Trojanowski J.Q. and Clark C.M., Journal of Alzheimer's Disease 31(2): 439-45, 2012, PMID:22571982

Read article

Biochemical Biomarkers of Depressive Symptoms in ADNI.

Arnold S.E., Xie S.X., Leung Y.Y., Kim E., Kling M.A., Wilson R., Bennett D., Hu W., Mackin S., Grossman M., Chen-Plotkin A., Wolk D., Lee V.M.-Y., Trojanowski J.Q., and Shaw L.M., Alzheimer's & Dementia 7(4): S312, 2011

Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence.

Crowe E.P., Tuzer F., Gregory B.D., Donahue G., Gosai S.J., Leung Y.Y., Yetkin E., Cohen J., Nativio R., Wang L.-S., Sell C., Bonini N.M., Berger S.L., Johnson F.B. and Torres C., Frontiers in Aging Neuroscience 8(): 208, 2016, PMID:27630559

Read article