TRANSFUSION MEDICINE AND THERAPEUTIC PATHOLOGY

Cellular Therapy

Overview

Cellular therapy activities within the Division of Transfusion Medicine and Therapeutic Pathology comprise the collection of cells from patients in the Apheresis Unit, the processing of those cells in the Hematopoietic Stem Cell Laboratory and/or Clinical Cell and Vaccine Production Facility (CVPF), and the transfusion of the processed products back into patients. The Hematopoietic Stem Cell Laboratory is accredited by the AABB, CAP, and FACT, and the CVPF is accredited by FACT.

Highlights

• A variety of cell-based therapies involving bone marrow-derived cells such as lymphocytes, dendritic cells and stem cells are currently ongoing or in development
• In addition, non-marrow derived cells such as neural stem cells, islet cells and myoblasts can be processed in the CVPF
• Processing techniques include: isolation/enrichment of particular cell lineages; cryopreservation and storage of cells and tissues; RNA isolation from tumor, growth and expansion of cells; and transduction (insertion) of experimental therapeutic genes into cells