TRANSFUSION MEDICINE AND THERAPEUTIC PATHOLOGY

Transfusion Medicine and Therapeutic Pathology

Overview

The Division of Transfusion Medicine and Therapeutic Pathology, serving as the therapeutic arm of the Department of Pathology and Laboratory Medicine, comprises the Hospital of the University of Pennsylvania (HUP) blood bank and transfusion service, an immunohematology reference laboratory, an apheresis/infusion unit, a full whole blood and plateletpheresis collection program, a hematopoietic progenitor collection and processing laboratory, and a clinical cell and vaccine production facility. Its very active clinical services provide over 60,000 units of blood and blood products per year to HUP patients through the blood bank and transfusion service, while capable of performing 10,000 procedures per year in the apheresis/infusion unit on outpatients and inpatients diagnosed with a variety of hematopoietic, immunologic, oncologic, and genetic disorders.

The Division consists of nine faculty members who provide medical oversight and consultation for these clinical activities throughout the University of Pennsylvania Health System (UPHS), and facilitate numerous interdepartmental clinical trials and translational research efforts. Each faculty member has his/her particular area of academic interest and receives support through funding from the National Institutes of Health (NIH), private industry, and non-profit foundations.
 

Highlights

• provide comprehensive transfusion medicine physician consultative services 24/7
• provide state-of the-art therapeutic apheresis procedures, including LDL-apheresis
• perform novel hematopoietic stem cell collection and cell processing/expansion procedures, including those for hematopoietic cell reconstitution and adoptive immunotherapy
• infuse the latest in biologics, including humanized monoclonal antibodies and other recombinant proteins
• serve as an interface for patients enrolled in numerous clinical trials and their sponsoring UPHS clinical investigators, institutes, and centers

Faculty

Don L. Siegel, MD, PhD, Director
Nicole Aqui, MD
Carl June, MD
Taku Kambayashi, MD, PhD
Bruce Levine, PhD
Una O’Doherty, MD, PhD
Daniel Powell, PhD
James Wilson, MD, PhD

Adjunct Faculty
Sandra Nance, MS, MT (ASCP) SBB
Senior Director, Immunohematology Reference Laboratory (IRL), Penn-Jersey Region, American Red Cross Blood Services
Constance M. Westhoff, PhD
Director of Immunohematology, Genomics, and Rare Blood, New York Blood Center


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Transfusion Medicine & Therapeutic Pathology
Nicole Alyse Aqui, MD

Assistant Professor of Clinical Pathology and Laboratory Medicine

University of Pennsylvania Perelman School of Medicine


Carl H. June, MD

Richard W. Vague Professor in Immunotherapy, Professor of Medicine

University of Pennsylvania Perelman School of Medicine


Taku Kambayashi, MD, PhD

Assistant Professor of Pathology and Laboratory Medicine

University of Pennsylvania Perelman School of Medicine


Bruce L. Levine, PhD

Barbara and Edward Netter Professor in Cancer Gene Therapy

University of Pennsylvania Perelman School of Medicine


Sandra Nance, MS, MT (ASCP) SBB

Senior Director, Immunohematology Reference Laboratory (IRL), Penn-Jersey Region, American Red Cross Blood Services

Adjunct Assistant Professor of Pathology and Laboratory Medicine


Una O'Doherty, MD, PhD

Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

University of Pennsylvania Perelman School of Medicine


Daniel J. Powell Jr., PhD

Research Associate Professor of Pathology and Laboratory Medicine, Associate Professor of Obstetrics and Gynecology

University of Pennsylvania Perelman School of Medicine


Donald L. Siegel, PhD, MD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Director, Division of Transfusion Medicine and Therapeutic Pathology

University of Pennsylvania Perelman School of Medicine


James M. Wilson, MD, PhD

Professor of Medicine, Professor of Pathology and Laboratory Medicine, Professor of Pediatrics

University of Pennsylvania Perelman School of Medicine

Director, Orphan Disease Center

Director, Gene Therapy Program


Constance M. Westhoff, PhD

Adjunct Assistant Professor of Pathology and Laboratory Medicine

University of Pennsylvania Perelman School of Medicine

Director of Immunohematology, Genomics, and Rare Blood, New York Blood Center