PEOPLE

Carl H. June, MD

Richard W. Vague Professor in Immunotherapy
Director, Center for Cellular Immunotherapies
Director, Parker Institute for Cancer Immunotherapy
University of Pennsylvania Perelman School of Medicine

Contact Information8-123
SCTR
Philadelphia, PA 19104
Office: (215) 573-3269
Fax: (215) 573-8590

Specialty Division

Transfusion Medicine & Therapeutic Pathology, Immunobiology and Experimental Pathology

Research Expertise

Research Interests
lymphocyte biology, with a major translational focus on ex vivo T-cell engineering for cancer and HIV cell based therapies.

Key words: T cells, human, gene therapy, genetic engineering, signal transduction.

Description of Research
The June Lab is primarily responsible for developing new CARs and new vectors for current and proposed indications. This lab also fosters the development of Penn students both in doctoral and post-doctoral programs. The June Laboratory provides researchers with the tools they need to translate laboratory insights into safe and effective cancer therapies. The June Laboratory works with University of Pennsylvania faculty members interested in moving biologically-focused research ideas into clinical trials. In addition, the June Laboratory has a cadre of faculty researchers focused on developing ways to enhance the ability of the natural immune system to recognize and eliminate tumor cells. Translational research is a core unit of the The Leonard and Madlyn Abramson Family Cancer Research Institute at the Abramson Cancer Center at the University of Pennsylvania. Created in December 1997 with a $100 million pledge from the Abramson Family Foundation, the Cancer Research Institute integrates research, education, and comprehensive patient care at the Abramson Cancer Center at the University of Pennsylvania. For more information, see the Translational Research Mission Statement.

Lab personnel:
Keisuke Watanabe, Ph.D.
Postdoctoral Researcher

Christopher Kloss, Ph.D.
Postdoctoral Researcher

Mauro Castellarin, Ph.D.
Postdoctoral Researcher

Biliang Hu, Ph.D.
Postdoctoral Researcher

Andrew Frisch
Research Specialist,B

Pratik Bhojnagarwala
Research Specialist,A

Tong Da
Research Specialist,C

Yanping Luo
Research Specialist,C

Decheng "DC" Song
Research Specialist,C

Kathleen Haines
Research Specialist,C

John Scholler, Staff Scientist
Lab Manager

Itmat Expertise

Dr. June directs the Program in Novel Biologics (PINB). This enhances the infrastucture to conduct translational investigation for chronic infections, autoimmunity and cancer.

Graduate Groups

Cell and Molecular Biology
Immunology
Pharmacology

Education

B.S. (Biology), United States Naval Academy , 1975
M.D. (Medicine ), Baylor College of Medicine, 1979

Specialty Certification

American Board of Internal Medicine, 1982
American Board of Internal Medicine Subspecialty of Oncology, 1985

Postgraduate Training

Research Fellow , World Health Organization Immunology Research and Training Center, Geneva, Switzerland, 1978-1979
Internship: Basic Medicine , National Naval Medical Center, Bethesda, Maryland, 1979-1980
Residency: Internal Medicine , National Naval Medical Center, Bethesda, Maryland, 1980-1982
Chief Resident: Internal Medicine , National Naval Medical Center, Bethesda, Maryland, 1982-1983
Fellow in Oncology , University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, 1983-1985

Awards and Honors

Michael E. DeBakey Scholar award for the Outstanding Medical Student, Baylor College of Medicine, 1978
Alpha Omega Alpha Medical Society, 1978
American Federation for Clinical Research, 1983-1992
Fellow, American College of Physicians, 1991
American Society for Clinical Investigation, 1992-2006
Legion of Merit, US Navy, 1996
Dexter Conrad Award, Office of Naval Research, Navy’s highest award for Scientific Achievement, 1996
Frank Brown Berry Prize in Federal Medicine, 1997
Burroughs Wellcome Fund Award: visiting professor in the basic medical sciences, 2001
William Osler Award, University of Pennsylvania School of Medicine, 2002
Lifetime Achievement Award, Leukemia and Lymphoma Society of America, 2002
Bristol-Myers Squibb Freedom to Discover Award, 2005-2009
Federal Laboratory Award for Excellence in Technology Transfer, 2005
American Association of Physicians, 2006
Top 10 Clinical Research Achievement Award/Clinical Research Forum, 2012
Elected to Institute of Medicine, 2012
Earnest Beutler Lecture and Prize, American Society of Hematology, 2012
Philadelphia Award, 2013
Richard V Smalley Award, Society for Immunotherapy of Cancer, 2013
Steinman Award for Human Immunology Research, American Association of Immunologists, 2014
Aubrey Evans Award / Ronald McDonald House, 2014
Elected to American Academy of Arts & Sciences, 2014
Hamdan Award for Medical Research Excellence, 2014
Taubman Prize for Excellence in Translational Medical Science, 2014
Karl Landsteiner Memorial Award, AABB, 2014
Watanabe Prize for Translational Research / Indianna University and Eli Lilly, 2015
Debrecen Award for Molecular Medicine / University of Debrecen, 2015
Paul Ehrlich and Ludwig Darmstaedter Prize, 2015
Lifetime Achievement Award Lecture / Miami Winter Symposium, 2015
E. Donnall Thomas Award Lecture / American Society for Blood and Marrow Transplantation, 2015

Memberships and Professional Organizations

American Society Hematology, 1986 - Present
National Institutes of Health, 1994 - Present
Clinical Immunology Society, 1995 - Present
Juvenile Diabetes Research Foundation International, 1999 - 2008
American Society of Gene and Cell Therapy, 1999 - Present
Leukemia & Lymphoma Society, 2002 - 2010
Pacific Ovarian Cancer Research Consortium, 2003 - 2008
Roger Williams Medical Center, Providence, RI, 2004 - 2007
Memorial Sloan Kettering Cancer Center, 2005 - Present
Alliance for Cancer Gene Therapy, 2006 - Present
Dana Farber Harvard Cancer Center, 2006 - 2008
International Society for Biological Therapy of Cancer, 2006 - Present
Foundation for the Accreditation of Cellular Therapy, 2007 - 2010
H. Lee Moffitt Cancer Center, 2007 - 2011
Telthon Fondazione Onlus, 2008 - 2010
Multiple Myeloma Research Foundation, 2008 - Present
University of Minnesota, 2008 - Present
Danish Council for Strategic Research, 2008 - Present
International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation, 2008 - 2009
United Kingdom Quinquennial Review, 2009 - Present
Gabrielle"s Angel Foundation for Cancer Research, 2009 - Present
Stanford University Cancer Center, 2010 - Present
Duke Cancer Institute, Duke University (Member, Scientific Advisory Board), 2012 - present

Web Links


Selected Publications

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

Porter David L, Levine Bruce L, Kalos Michael, Bagg Adam, June Carl H, The New England journal of medicine 365(8): 725-33, 2011, PMID:21830940

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced Leukemia.

Kalos Michael, Levine Bruce L, Porter David L, Katz Sharyn, Grupp Stephan A, Bagg Adam, June Carl H, Science translational medicine 3(95): 95ra73, 2011, PMID:21832238

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Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.

Rapoport Aaron P, Aqui Nicole A, Stadtmauer Edward A, Vogl Dan T, Fang Hong-Bin, Cai Ling, Janofsky Stephen, Chew Anne, Storek Jan, Akpek Gorgun, Badros Ashraf, Yanovich Saul, Tan Ming T, Veloso Elizabeth, Pasetti Marcela F, Cross Alan, Philip Sunita, Murphy Heather, Bhagat Rita, Zheng Zhaohui, Milliron Todd, Cotte Julio, Cannon Andrea, Levine Bruce L, Vonderheide Robert H, June Carl H, Blood 117(3): 788-97, 2011, PMID:21030558

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases.

Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, Wang N, Lee G, Bartsevich VV, Lee YL, Guschin DY, Rupniewski I, Waite AJ, Carpenito C, Carroll RG, Orange JS, Urnov FD, Rebar EJ, Ando D, Gregory PD, Riley JL, Holmes MC, June CH., Nat Biotechnol. 7(): 808-16, 2008, PMID:18587387

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The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

Paulos Chrystal M, Carpenito Carmine, Plesa Gabriela, Suhoski Megan M, Varela-Rohena Angel, Golovina Tatiana N, Carroll Richard G, Riley James L, June Carl H, Science translational medicine 2(55): 55ra78, 2010, PMID:20980695

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A human memory T cell subset with stem cell-like properties.

Gattinoni Luca, Lugli Enrico, Ji Yun, Pos Zoltan, Paulos Chrystal M, Quigley Máire F, Almeida Jorge R, Gostick Emma, Yu Zhiya, Carpenito Carmine, Wang Ena, Douek Daniel C, Price David A, June Carl H, Marincola Francesco M, Roederer Mario, Restifo Nicholas P, Nature medicine 17(10): 1290-7, 2011, PMID:21926977

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Engineering lymphocyte subsets: tools, trials and tribulations.

June CH, Blazar BR, Riley JL, Nature Reviews Immunology 9(10): 704-16, 2009, PMID:19859065

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

Carpenito Carmine, Milone Michael C, Hassan Raffit, Simonet Jacqueline C, Lakhal Mehdi, Suhoski Megan M, Varela-Rohena Angel, Haines Kathleen M, Heitjan Daniel F, Albelda Steven M, Carroll Richard G, Riley James L, Pastan Ira, June Carl H, Proceedings of the National Academy of Sciences of the United States of America 106(9): 3360-5, 2009, PMID:19211796

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Human T regulatory cell therapy: take a billion or so and call me in the morning.

Riley James L, June Carl H, Blazar Bruce R, Immunity 30(5): 656-65, 2009, PMID:19464988

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Putting the brakes on BTLA in T cell-mediated cancer immunotherapy.

Paulos CM, June CH, Journal of Clinical Investigation 120(1): 76-80, 2010, PMID:20038807

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