Jacquelyn Roth, Ph.D., DABMGG

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact Information3400 Spruce Street
7.103 Founders Pavilion
Philadelphia, PA, 19104

Specialty Division

Precision and Computational Diagnostics


BA (Major - Biology, Minor - Applied Mathematics), Franklin & Marshall College, 2004
PhD (Genetics), Thomas Jefferson University, 2011

Specialty Certification

American Board of Medical Genetics and Genomics, Clinical Cytogenetics, 2013
American Board of Medical Genetics and Genomics, Clinical Molecular Genetics, 2015

Postgraduate Training

ABMGG Fellowship, Clinical Cytogenetics, The Children's Hospital of Philadelphia, 2011-2013
ABMGG Fellowship, Clinical Molecular Genetics, The Children's Hospital of Philadelphia, 2013-2014

Awards and Honors

John Marshall Scholar, Franklin and Marshall College, 2000-2004
Howard Hughes Scholar, Franklin and Marshall College, 2001-2004
Alpha Epsilon Delta Premedical Honor Society, Franklin and Marshall College, 2003-2004
M. Munson Award in Dance, Franklin and Marshall College, 2004
Biology Departmental Honors, Franklin and Marshall College, 2004
Marie D’Agostino Senior Biology Award, Franklin and Marshall College, 2004
NIH Training Grant, Thomas Jefferson University, 2006-2009
Jefferson College of Graduate Studies Alumni Travel Fellowship, Thomas Jefferson University, 2008
Jefferson College of Graduate Studies Alumni Travel Fellowship, Thomas Jefferson University, 2011
Cis B. Golder Quality of Life Grant, Living Beyond Breast Cancer, 2011
Mouse Genetics Travel Scholarship, International Mammalian Genome Conference, 2011
The Fredric Rieders Renaissance Foundation Graduate Student Recognition Award, Thomas Jefferson University, 2011
Going Beyond Award, Living Beyond Breast Cancer, 2012
Spirit of the Promise Award, Susan G. Komen Philadelphia, 2012
Student Travel Award, American Cytogenetics Conference, 2012
Jefferson College of Graduate Studies Alumni Prize for Best Thesis, Thomas Jefferson University, 2012
Research Poster Day Prize, The Children’s Hospital of Philadelphia, 2014

Memberships and Professional Organizations

American Association for the Advancement of Science, 2007 - 2009
The American Society for Cell Biology, 2008 - 2009
Susan G. Komen for the Cure Philadelphia, 2010 - 2016
Living Beyond Breast Cancer, 2010 - Present
Young Survival Coalition, 2010 - 2014
National Post-Doctoral Association, 2011 - 2014
American Cytogenetics Conference, 2012 - Present
Association for Molecular Pathology, 2014 - Present
College of American Pathologists (Member and Site Inspector), 2016 - Present

Web Links

Selected Publications

Discordance Among Biomarkers for Anti-PD1 Therapy Response: Tumor Mutational Burden and Anti-PD-L1 Staining

Hess, P.R., Velu, P.D., Bigedli, A., Morrissette, J.J.D., Rosenbaum, J.N. and Roth, J.J., J Mol Diagn 19(6): 1039, 2017.

Calculation of mutational burden in a clinical targeted next-generation sequencing (NGS) panel for solid tumors.

Velu, P.D., Bigedli, A., Hess, P., Roth, J.J., Rosenbaum, J., and Morrissette, J.J.D., J Mol Diagn 19(6): 1024, 2017.

Copy number alterations determined by single nucleotide polymorphism array testing in the clinical laboratory are indicative of gene fusions in pediatric cancer patients

Busse Tracy M, Roth Jacquelyn J, Wilmoth Donna, Wainwright Luanne, Tooke Laura, Biegel Jaclyn A, Genes Chromosomes Cancer 56(10): 730-749, 2017, PMID:28597942

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Improvements in Workflow after Verification and Implementation of the cobas HPV Test

Roth, J.J., Windon, A.L., Strubinger, J., Carlin, A., Gentile, C.S., Watt, C.D., McGrath, C.M., and Van Deerlin, V.M., J Mol Diagn 18(6): 970, 2016.

Validation of the GenMark RUO eSensor HCVg Direct Test for Hepatitis C Virus Genotyping

Farooqi, M.S., Gentile, C.S., Roth, J.J., and Van Deerlin, V.M., J Mol Diagn 18(6): 974, 2016.

BCR-ABL1 molecular responses at 12-18 months predict long-term event-free survival in patients with tyrosine kinase inhibitor (TKI)-treated chronic myelogenous leukemia (CML)

Press, R., Watt, C.D., Cai, L., Van Deerlin, V.M., Roth, J.J., Gentile, C.S., Loren, A., and Eickelberg, G., J Mol Diagn 18(6): 964, 2016.

Integration of Rapid Molecular Testing for Influenza and RSV into Existing Diagnostic Workflow

Li, Y., Alby, K., Watt, C.D., and Roth, J.J., J Mol Diagn 18(6): 979, 2016.

Comparison of Roche Cobas to Hologic Cervista Assays in the Evaluation of High-Risk HPV Testing from Gynecologic Cytology Specimens

Windon, A., Roth, J., Strubinger, J., McGrath, C., Van Deerlin, V., American Journal of Clinical Pathology 146(1): S97, 2016.

Precision and Computational Diagnostics Newsletter

Editors: Pritchard, L., Velu, P., and Roth, J.J., Print/Electronic, 2016 to Present

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status.

Roth Jacquelyn J*, Fierst Tamara M*, Waanders Angela J, Yimei Li, Biegel Jaclyn A, Santi Mariarita (*Co-first authors), Journal of neuropathology and experimental neurology 75(4): 306-15, 2016, PMID:26945035

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