Tatiana Akimova (nee: Tikhomirova), MD, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationThe Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
914G Abramson Research Center
3615 Civic Center Blvd, Philadelphia, PA 19104,USA
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880



MD St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001
PhD (Immunology and Allergy), Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006

Specialty Certification

Postgraduate Training

Internship in Internal Medicine, including Endocrinology, Department of Therapy and Endocrine Diseases, St. Petersburg State Pavlov Medical University, 2001-2002
PhD Fellowship in Immunology and Allergy, Center for Molecular medicine, St. Petersburg State Pavlov Medical University., 2003-2006
Residency in Immunology and Allergy , Center for Molecular Medicine and Department of Therapy and Allergic Diseases,
St. Petersburg State Pavlov Medical University, 2005-2007

Awards and Honors

National Science Forum
1st & 2nd award winner of young scientist competition (for the best scientific work) at 7th, 8th and 9th National Science Forum with international participation “Days of Immunology in St. Petersburg” in 2003, 2004, 2005, 2003
Young Scientist Award 3rd award winner for the best scientific work, at St. Petersburg State Pavlov Medical University Young Scientist Society’s Russian National Conference with international participation, in 2004, 2004
Clinical Immunology
The paper “Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs” listed in Top 25 hottest articles, 2010
Molecular Cell Biology
The paper “Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells” listed in “Articles of significant interest selected from this issue., 2011
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was ranked as one of the top 2% of published articles in these fields by F1000., 2011
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was listed as in the top1% most cited papers at PLoS One., 2017

Memberships and Professional Organizations

American Association of Immunologists, 2012 - Present

Web Links

Selected Publications

The effects of Tacrolimus on T-cell proliferation are short-lived: A pilot analysis of immune function testing.

Laskin BL, Jiao J, Baluarte HJ, Amaral S, Furth SL, Akimova T, Hancock WW, Levine MH, Reese PP, Beier UH., Transplantation Direct 3(): e199, 2017

Regulatory T cell signatures in liver transplant recipients successfully weaned from immunosuppression: Getting from here to there.

Levine Matthew H, Akimova Tatiana, Murken Douglas R, Hancock Wayne W, Liver Transplantation 23(7): 875-877, 2017, PMID:28508569

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Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments.

Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH, Cell Metabolism 25(6): 1282-1293.e7, 2017, PMID:28416194

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Utility of IL-2 complexes in promoting vascularized composite allograft survival.

Xu H, Dahiya S, Wang L, Akimova T, Han R, Levine MH, Hancock WW, Levin LS., American Transplant Congress, Chicago,, 2017

Location matters: Unique functional and transcriptional, but not flow cytometric, characteristics of intratumoral FOXP3+ Tregs vs. Tregs from other sites of patients with lung tumors.

Akimova T, Zhang T, Eruslanov E, Singhal S, Albelda SM, Hancock WW., Abstract #1013. AACR Proceedings: Abstracts 1-3062. ISBN: 9781370055180. Annual Meeting of the American Association for Cancer Research, Washington,, 2017

Human lung tumor FOXP+ Tregs upregulate four “Treg-locking” transcription factors

Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW., JCI Insight (In press), 2017

Utility of IL-2 complexes in promoting the survival of murine orthotopic forelimb vascularized composite allografts.

Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, Zhang Y, Qin L, Levine MH, Hancock WW, Levin LS., Transplantation. 2017; doi: 10.1097/tp.0000000000001852., 2017

Ubiquitin-specific protease-7 inhibition impairs Tip60-dependent Foxp3+ T-regulatory cell function and promotes antitumor immunity.

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW, EBioMedicine 13(): 99-112, 2016, PMID:27769803

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Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function.

Akimova T, Levine MH, Beier UH, Hancock WW, Methods In Molecular Biology (Clifton, N.J.) 1371(): 43-78, 2016, PMID:26530794

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Regulatory T cells in pulmonary sarcoidosis.

Patterson KC, Akimova T, Hancock WW, American Thoracic Society; San Francisco,, 2016