Tatiana Akimova (nee: Tikhomirova), MD, PhD

Research Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationThe Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
914G Abramson Research Center
3615 Civic Center Blvd, Philadelphia, PA 19104,USA
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880



MD (Internal Medicine), St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001
PhD (Immunology and Allergy), Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006

Specialty Certification

Postgraduate Training

Internship in Internal Medicine, including Endocrinology, Department of Therapy and Endocrine Diseases, St. Petersburg State Pavlov Medical University, 2001-2002
PhD Fellowship in Immunology and Allergy, Center for Molecular medicine, St. Petersburg State Pavlov Medical University., 2003-2006
Residency in Immunology and Allergy , Center for Molecular Medicine and Department of Therapy and Allergic Diseases,
St. Petersburg State Pavlov Medical University, 2005-2007

Awards and Honors

National Science Forum
1st & 2nd award winner of young scientist competition (for the best scientific work) at 7th, 8th and 9th National Science Forum with international participation “Days of Immunology in St. Petersburg” in 2003, 2004, 2005, 2003
Young Scientist Award 3rd award winner for the best scientific work, at St. Petersburg State Pavlov Medical University Young Scientist Society’s Russian National Conference with international participation, in 2004, 2004
Clinical Immunology
The paper “Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs” listed in Top 25 hottest articles, 2010
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was ranked as one of the top 2% of published articles in these fields by F1000., 2011
Molecular Cell Biology
The paper “Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells” listed in “Articles of significant interest selected from this issue., 2011
PLoS One
The paper "Helios expression is a marker of T cell activation and proliferation" was listed as in the top1% most cited papers at PLoS One., 2017

Memberships and Professional Organizations

American Association of Immunologists, 2012 - Present

Web Links

Selected Publications

Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity

Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW, The Journal of Clinical Investigation 130(4): 1830-42, 2020, PMID:31917688

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Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity

Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW, The Journal of Clinical Investigation, 2020, PMID:32790649

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HDAC10 deletion promotes Foxp3(+) T-regulatory cell function

Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin, A., Wallace, D. C., Hancock, W. W., Scientific Reports 1(10): 424, 2020, PMID:31949209

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Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM and Eruslanov EB, Sci Transl Med 11(479): , 2019

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW, Cancers 4(11): , 2019, PMID:31003455

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Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms

Negorev, D., Beier, U. H., Zhang, T., Quatromoni, J. G., Bhojnagarwala, P., Albelda, S. M., Singhal, S., Eruslanov, E., Lohoff, F. W., Levine, M. H., Diamond, J. M., Christie, J. D., Hancock, W. W., Akimova, T., Sci Rep 8(1): 3135, 2018

Loss of HDAC6 alters gut microbiota and worsens obesity

Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, Blaser MJ, FASEB J fj201701586R(): , 2018

How little is known about the role of human FOXP3+ Tregs in tumors

Akimova T, Hancock WW, Expert Opin Ther Targets 22(8): , 2018

Obesity-driven IL-18 inhibits the suppressive function of FOXP3+ T-regulatory (Treg) cells

Akimova T, Zhang T, Beier UH, Jiao J, Diamond JM, Christie JD, et al., The Journal of Immunology 200( (1 Supplement)): 166.52, 2018

Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation

Wang L, Beier UH, Akimova T, Dahiya S, Han R, Samanta A, Levine MH, and Hancock WW, Am J Transplant 18(8): , 2018