Stephan Kadauke, MD, PhD
Associate Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationChildren's Hospital of Philadelphia
CTRB, 3rd Floor, Room 3016
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-616-9737
Research Expertise
Reproducible research, tidyverse, R, RStudio, R Markdown, Quarto, clinical data science, machine learning, tidymodels, GitHub, gene therapy, erythropoiesis, epigenetics, chromatin, CAR-T cells, immunotherapy, virus-specific cytotoxic T lymphocytes, GMP manufacturing
Clinical Expertise
Cellular therapy, cGMP, stem cells, bone marrow transplant, chimeric antigen receptor, CAR-T cells, virus-specific cytotoxic T lymphocytes, T/B cell depletion, cell manufacturing, graft manipulation, CliniMACS Prodigy, transfusion medicine, apheresis, red blood cell exchange, plasma exchange, thalassemia, sickle cell disease, thrombosis and hemostasis, coagulation, utilization management, laboratory information systems, healthcare analytics, clinical informatics, pathology informatics, datamart, enterprise data warehouse
Education
BA (Biochemistry, summa cum laude), Columbia University, 2005
PhD (Cell and Molecular Biology), Perelman School of Medicine at the University of Pennsylvania, 2012
MD, Perelman School of Medicine at the University of Pennsylvania, 2014
Specialty Certification
Clinical Pathology, American Board of Pathology, 2018
Transfusion Medicine, American Board of Pathology, 2018
Qualification in Apheresis, American Society for Apheresis, 2018
PBC - Certified Tidyverse Instructor, RStudio, 2019
Physician Builder, Epic, Inc., 2020
University of Pathology Informatics, American Society of Clinical Pathology, 2020
Clinical Informatics, American Board of Pathology, 2021
Associate, Amazon Web Services (AWS) Certified Solutions Architect, 2022
Postgraduate Training
Residency in Clinical Pathology, Massachusetts General Hospital, 2014-2018
Chief Resident , Massachusetts General Hospital, 2015-2015
Transfusion Medicine Fellowship, Harvard Medical School, 2016-2017
Awards and Honors
Phi Beta Kappa, Early Induction for Top 2% of Graduating Class, Columbia University, 2004
Benjamin and Mary Siddons Measey Foundation Fellowship, University of Pennsylvania, 2005-2009
Summa cum laude, Columbia University, 2005
Saul Winegrad Award for Outstanding Dissertation, University of Pennsylvania, 2013
Roy G. Williams Award for Meritorious Research in Basic Medical Sciences, University of Pennsylvania, 2013
Oral Abstract Award, 2022 ASTCT Meeting, 2022-2022
Memberships and Professional Organizations
The Sumaira Foundation for Neuromyelitis Optica, 2014 - 2018
AABB, 2017 - Present
American Society of Apheresis (ASFA), 2018 - Present
College of American Pathologists, 2019 - Present
Association for Pathology Informatics (API), 2019 - Present
International Society for Cellular Therapy (ISCT), 2019 - Present
American Association for Clinical Chemistry (AACC), 2019 - Present
R/Medicine, 2020 - Present
American Society for Transplantation and Cellular Therapy (ASTCT), 2020 - Present
American Medical Informatics Association (AMIA), 2021 - present
Web Links
CHOP Cell and Gene Therapy Laboratory
CHOP Cell and Gene Therapy Informatics Blog
Selected Publications
Behind the Scenes of CAR-T Cell Therapy at CHOP: the Role of the Clinical Labs
Kadauke S, YouTube, 2023.
Automation of Hematopoietic Cell Transplant Outcomes Reporting Leads to Dramatic Reduction of Errors Reported to Real-World Data Registry
Anderson DS, Hanna RS, Pashmineh Azar AR, Collier V, Hankins P, Loudon B, Olson TS, Grupp SA, Phillips CA, Kadauke S, Transplantation and Cellular Therapy 29(3): 207.e1-207.e5, 2023. PMID:36610491
Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy
Newman H, Li Y, Liu H, Myers R, Tam V, DiNofia A, Wray L, Rheingold S, Callahan C, White C, Baniewicz D, Winestone L, Kadauke S, Diorio C, June C, Getz K, Aplenc R, Teachey D, Maude S, Grupp SA, Bona K, Leahy AB, Blood 141(6): 606-619, 2023. PMID:36351239
Should We Teach Data Science to Laboratorians-in-Training?
Kadauke S, The Journal of Applied Laboratory Medicine 8(1): 208-212, 2023.
Manufacture and Characterization of GMP-Compliant SARS-COV-2 Cytotoxic T Lymphocytes
Chu Y, Milner J, Lamb M, Maryamchik E, Rigot O, Ayello J, Harrison L, Shaw R, Behbehani GK, Mardis ER, Miller K, Prakruthi L, Venkata R, Chang H, Lee D, Rosenthal E, Kadauke S, Bunin N, Talano JA, Johnson B, Wang Y, Cairo MS, Journal of Infectious Diseases, 2022. PMID:36583990
REDCapTidieR: Extract REDCap Databases into Tidy Tibbles
Hanna RS, Kadauke S. Comprehensive R Archive Network, 2022.
REDCapTidieR: Extracting REDCap Databases into Tidy Tibbles
Kadauke S. YouTube, 2022.
R/Medicine 101: Intro to R for Clinical Data
Kadauke S, Rudolf J, Mathias PC. YouTube, 2022.
Impact of Socioeconomic Status on Survival after CD19 CART Therapy
Newman H, Li Y, Liu H, Tam V, Myers RM, DiNofia AM, Callahan C, White CW, Baniewicz D, Kadauke S, Diorio C, Teachey DT, Rheingold SR, Getz KD, June CH, Aplenc R, Maude SL, Grupp SA, Bona K, Barz Leahy AE, Journal of Clinical Oncology 40(16): 7013, 2022.
A Machine Learning Model that Incorporates CD45 Mean Fluorescence Intensity (MFI) and Cell Composition Predicts Poor Viability of Hematopoietic Progenitor Cells after Freeze-Thaw.
Al-Riyami AZ, Hanna RS, Pashmineh Azar AR, Maryamchik E, Zheng X, Zhang X, Finn C, Giacobbe N, Rieser R, Ghasemi Tahrir F, Machietto R, Choudhari SS, Kadauke S, Wang Y, Cytotherapy 24(5): S99-S100, 2022.
