PEOPLE

Yavuz Bayram, MD

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Education

MD University of Istanbul, Cerrahpasa School of Medicine-English Section, Istanbul, Turkey, 2007

Specialty Certification

Turkish Board-Certified Medical Geneticist, 2012
Clinical Laboratory Technologist License, Molecular Diagnosis/Genetic Testing, 2018
Clinical Laboratory Technologist License, Cytogenetics, 2019

Postgraduate Training

Medical Genetics Residency, Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2008-2012
Visiting Scientist, Friedrich-Schiller-University of Jena, Human Genetics Institute, Jena, Germany, 2011-2011
Short Term Scholar, Department of Molecular and Human Genetics, Dr. James R. Lupski Lab, Baylor College of Medicine, Houston, TX, USA, 2012-2013
Attending Physician, Medical Genetics, Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2013-2013
Post-Doctoral Associate, Department of Molecular and Human Genetics, Dr. James R. Lupski Lab, Baylor College of Medicine, Houston, TX, USA, 2013-2017
Post-Doctoral Fellow, ABMGG Lab Genetics & Genomics Fellowship Program, Dept. of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA, 2017-2020

Awards and Honors

Best Oral Presentation. 3-M Syndrome: Clinical – Radiological – Molecular Evaluation of Six Cases., 2009
Full bursary for Germany visit expenses by German Academic Exchange Service. Project name: Genotype-Phenotype Correlation of the Patients with Small Supernumerary Marker Chromosome., 2011
Best Oral Presentation and bursary for next conference expenses. The role of Turkey in Baylor-John`s Hopkins Mendelian Exome Sequencing Project., 2014

Memberships and Professional Organizations

American Society of Human Genetics, 2013 - Present
European Society of Human Genetics, 2015 - 2016

Web Links


Selected Publications

Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide

Gonzaga-Jauregui C, Yesil G, Nistala H, Gezdirici A, Bayram Y, Nannuru KC, Pehlivan D, Yuan B, Jimenez J, Sahin Y, Paine IS, Akdemir ZC, Rajamani S, Staples J, Dronzek J, Howell K, Fatih JM, Smaldone S, Schlesinger AE, Ramirez N, Cornier AS, Kelly MA, Haber R, Chim SM, Nieman K, Wu N, Walls J; Baylor-Hopkins Center for Mendelian Genetics, Regeneron Genetics Center, Poueymirou W, Siao CJ, Sutton VR, Williams MS, Posey JE, Gibbs RA, Carlo S, Tegay DH, Economides AN, Lupski JR., Eur J Hum Genet., 2020, PMID:32376988

Read article

The genomics of arthrogryposis, a complex trait: Candidate genes and further evidence for oligogenic inheritance

Pehlivan D, Bayram Y (co-first author), Gunes N, Coban- Akdemir Z, Shukla A, Tatjana B, Tabakci B, Sahin Y, Gezdirici A, Fatih JM, Yilmaz-Gulec E, Yesil G, Punetha J, Ocak Z, Grochowski CM, Karaca E, Mutlu-Albayrak H, Radhakrishnan P, Erdem HB, Sahin I, Yildirim T, Bayhan IA, Bursali A, Elmas M, Yuksel Z, Ozdemir O, Silan F, Yildiz O, Yesilbas O, Isikay S, Balta B, Gu S, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM, Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Gibbs RA, Tsiakas K, Hempel M, Girisha KM, Gul D, Posey JE, Elcioglu NH, Tuysuz B, Lupski JR., Am J Hum Genet. 105(1): 132-150, 2019, PMID:31230720

Read article

Exome sequencing of a primary ovarian insufficiency cohort reveals common molecular etiologies for a spectrum of disease

Jolly A, Bayram Y (co-first author), Turan S, Aycan Z, Tos T, Abali ZY, Hacihamdioglu B, Coban Akdemir ZH, Hijazi H, Bas S, Atay Z, Guran T, Abali S, Bas F, Darendeliler F, Colombo R, Barakat TS, Rinne T, White JJ, Yesil G, Gezdirici A, Gulec EY, Karaca E, Pehlivan D, Jhangiani SN, Muzny DM, Poyrazoglu S, Bereket A, Gibbs RA, Posey JE, Lupski JR., J Clin Endocrinol Metab. 104(8): 3049-3067, 2019, PMID:31042289

Read article

Design and validation of a single customized next-generation sequencing capture library for neurodevelopmental, cardiac, immune, and inflammatory bowel diseases.

Bayram Y, Barrows J, Khan W, Fox R, Shi L, Cai1 G, Cai1 X, Manheimer K, Mendiratta-Vij G, Jiang W, Yang Y, Sha Y, Arif M, Wan H, Spencer E, Cody N, Lu X, Kim J, Hibbs D, Croken M, Holt J, McLellan A, Van den Berg S, Schadt E, Edelmann L, Suer F., American Society of Human Genetics 69th Annual Meeting, Houston, Texas/USA., 2019

Clinical Significance and Distribution of Absence of Heterozygosity in a Large Clinical Chromosomal Microarray Cohort.

Bayram Y, Singh R, Guo T, Shi L, Edelmann L, Scott SA., American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting, Seattle, Washington/USA., 2019

Phenotypic expansion illuminates multilocus pathogenic variation

Karaca E, Posey JE, Coban-Akdemir Z, Pehlivan D, Harel T, Jhangiani SN, Bayram Y, Song X, Bahrambeigi V, Ozalp Yuregir O, Bozdogan S, Yesil G, Isikay S, Muzny D, Gibbs RA, Lupski JR., Genet Med 20(12): 1528-1537, 2018, PMID:29790871

Read article

REST final-exon-truncating mutations cause hereditary gingival fibromatosis

Bayram Y, White JJ, Elcioglu N, Cho MT, Zadeh N, Gedikbasi A, Palanduz S, Ozturk S, Cefle K, Kasapcopur O, Coban Akdemir Z, Pehlivan D, Begtrup A, Carvalho CMB, Paine IS, Mente A, Bektas Kayhan K, Karaca E, Jhangiani SN, Muzny DM, Gibbs RA, Lupski JR., Am J Hum Genet. 101(1): 149-156, 2017, PMID:28686854

Read article

Homozygous and hemizygous CNV detection from exome sequencing data in a Mendelian disease cohort

Gambin T, Akdemir ZC, Yuan B, Gu S, Chiang T, Carvalho CM, Shaw C, Jhangiani S, Boone PM, Eldomery MK, Karaca E, Bayram Y, Stray-Pedersen A, Muzny D, Charng WL, Bahrambeigi V, Belmont JW, Boerwinkle E, Beaudet AL, Gibbs RA, Lupski JR., Nucleic Acids Res. 45(4): 1633-1648, 2017, PMID:27980096

Read article

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders

Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban-Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LT, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR., J Allergy Clin Immunol. 139(1): 232-245, 2017, PMID:27577878

Read article

Genes that affect brain structure and function identified by rare variant analyses of Mendelian neurologic disease

Karaca E, Harel T, Pehlivan D, Jhangiani SN, Gambin T, Coban Akdemir Z, Gonzaga-Jauregui C, Erdin S, Bayram Y, Campbell IM, Hunter JV, Atik MM, Van Esch H, Yuan B, Wiszniewski W, Isikay S, Yesil G, Yuregir OO, Tug Bozdogan S, Aslan H, Aydin H, Tos T, Aksoy A, De Vivo DC, Jain P, Geckinli BB, Sezer O, Gul D, Durmaz B, Cogulu O, Ozkinay F, Topcu V, Candan S, Cebi AH, Ikbal M, Yilmaz Gulec E, Gezdirici A, Koparir E, Ekici F, Coskun S, Cicek S, Karaer K, Koparir A, Duz MB, Kirat E, Fenercioglu E, Ulucan H, Seven M, Guran T, Elcioglu N, Yildirim MS, Aktas D, Alikaşifoğlu M, Ture M, Yakut T, Overton JD, Yuksel A, Ozen M, Muzny DM, Adams DR, Boerwinkle E, Chung WK, Gibbs RA, Lupski JR., Neuron 88(3): 499-513, 2015, PMID:26539891

Read article