Elizabeth M. Margolskee, MD, MPH
Associate Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact Information3401 Civic Center Boulevard
Philadelphia, PA, 19104
Office: 6316808643
Specialty Division
Hematopathology
Other Expertise
On my first day as a lab director, I learned that our entire dayshift staff had been exposed to COVID-19 in the workplace and had to quarantine. Although no one became seriously ill, this experience framed my relationship with laboratory professionals, and highlighted their role as front line workers.
I work closely with Surabhi Mulchandani, Vice Chair for Laboratory Administration, and other leadership in the department, to develop sustainable, ongoing strategies to develop and strengthen the pathology workforce.
Clinical Expertise
I am a hematopathologist and Director of the hematology laboratory at Children's Hospital of Philadelphia. I came to hematopathology originally because I wanted to care for critically ill patients alongside intelligent, curious clinicians in a collaborative fashion. I also enjoy interacting with our strong flow cytometrists, medical technologists, molecular pathologists, cytogeneticists, histotechs and pathology assistants, who make my work possible.
I am interested in quality and process improvement in the lab, and I am particularly fascinated by pediatric myeloid neoplasms.
Education
AB Harvard University, Cambridge, MA, 2006
MD Mount Sinai School of Medicine, New York, NY, 2010
MPH (Epidemiology), Columbia University Mailman School of Public Health, 2014
Specialty Certification
American Board of Pathology, Anatomic and Clinical Pathology, 2015
American Board of Pathology, Hematopathology, 2016
Postgraduate Training
Resident, Anatomic/Clinical Pathology, NYPH-Columbia University Medical Center, New York, NY, 2010-2015
Chief Resident, Anatomic/Clinical Pathology NYPH-Columbia University Medical Center, New York, NY, 2012-2013
Fellow, Hematopathology, NYPH-Weill Cornell, New York, NY, 2015-2016
Awards and Honors
Hoopes Prize for Senior thesis, 2006
Vermeule Prize for excellence in Archaeological Scholarship, 2006
Honorable Mention: Gold Foundation Humanism in Medicine Essay Contest, 2009
Wyman Scholar at Mailman School of Public Health, 2013
American Society of Hematology Abstract Achievement Award, 2013
American Society of Hematology Abstract Achievement Award, 2015
Best Podium Presentation, 8th Annual CHOP Education Day, 2025
Memberships and Professional Organizations
United States & Canadian Academy of Pathology, 2012 - Present
College of American Pathologists, 2016 - Present
AIDS Malignancies Consortium, 2017 - 2019
Society for Hematopathology, 2018 - Present
American Society for Clinical Pathology, 2022 - Present
Web Links
Selected Publications
Benchmarking Transformer Embedding Models for Biomedical Terminology Standardization
Lahiri A, Shukla S, Stear B, Ahooyi TM, Beigel K, Margolskee E, Taylor D., Mach Learn Appl 21(): 100683, 2025
EBV-Negative CD20+ Plasma Cell Posttransplant Lymphoproliferative Disorder of the Airway following Liver Transplant in a 16-Month Old
Zheng DJ, Margolskee E, Borek RC, Devine KJ., Pediatr Blood Cancer 79(9): e31901, 2025
Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists
Li D, Tasian SK, Wertheim G, Rheingold SR, Bernt KM, Newman H, Wainwright L, Wilmoth DM, Thiel B, Surrey LF, Margolskee E, Pillai V, Luo M, Paessler ME, Hunger SP, Li MM, Zhong Y., Haematologica 110(8): 1861-1864, 2025
Enhanced Interprofessional Communication Between Nurses and Laboratory Scientists Reduces Specimen Cancellation Rate
Caitlyn Musick, Grace McGrath, Megan McAuley, Elizabeth Margolskee, CHOP Education Day, 2025
Optimizing Reticulocyte Analysis in Anemic Patients: A 1:3 Dilution versus Manual Counting for Flag Resolution
Barry D, Margolskee E, Association for Diagnostics and Laboratory Medicine Annual Meeting, 2025
Clinical, Immunophenotypic, and Genomic Findings of Acute Myeloid Leukemia with RAM Immunophenotype: Comparison with Other CD56-positive Acute Leukemias
Hamdan H, Liu Y, Wang SA, Bledsoe J, Chisholm KM, Siddon A, Ohgami R, George TI, Kurzer J, Hasserjian RP, Arber DA, Bagg A, Foucar K, Margolskee E, Laczko D, Chen W, Fuda F, Aggarwal N, Weinberg OK, eJHaem, 2024
Addressing patient safety and interprofessional communication through the implementation of a Challenging Interactions reporting tool in a clinical laboratory
Chandan Kular, Kenneth Smith, Kara Thompson, Elizabeth Margolskee, CHOP Employee Well-being Summit, 2024
Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J, J Clin Pathol, 2023, PMID:37940376
Transdifferentiation of B-lymphoblastic Leukemia to Histiocytic Sarcoma After Immunotherapy
Fenu EM, Margolskee E, Pillai V, American Journal of Hematology 98(8): E216-E218, 2023, PMID:37259821
Optimizing ISLH lymphocytosis and monocytosis thresholds for manual differential smear review in the pediatric setting
Dana Martin, Megan Zoltowski, Emily Williams, Elizabeth Margolskee, IJLH 45(): 76, 2023
