Ruihe (Ray) Lin, MD, PhD
Assistant Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
6 Founders Pavilion
3400 Spruce St.
Philadelphia, PA 19104
Tel: 215-662-8627
Fax: 215-662-1694
Email: ruihe.lin@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Clinical Expertise
Genitourinary Pathology
GI and Liver Pathology
Graduate Groups
Cell and Molecular Biology
Immunology
Education
MBBS Fudan University
Master of Surgery Shanghai JiaoTong University (former Shanghai Second Medical University)
PhD (Medicine, Human Anatomy & Histoembryology), Fudan University
Specialty Certification
Educational Commission for Foreign Medical Graduates (ECFMG) Certificate, 2016
Anatomic Pathology and Clinical Pathology (AP/CP), American Board of Pathology, 2023
Postgraduate Training
Resident, Anatomic Pathology and Clinical Pathology, Thomas Jefferson University Hospital, 2019-23
Fellow, Surgical Pathology, Hospital of the University of Pennsylvania, 2023-24
Fellow, Genitourinary Pathology, The Johns Hopkins Hospital, 2024-25
Awards and Honors
The College of American Pathologists (CAP) Foundation: Translational Diagnostics Advanced Training Grant, 2022
Translational Diagnostics Advanced Training, Ventana Medical Systems of Roche Tissue Diagnostics, Tucson, AZ
Memberships and Professional Organizations
United States and Canadian Academy of Pathology (USCAP)
College of American Pathologists (CAP)
American Society for Clinical Pathology (ASCP)
Chinese American Pathologists Association (CAPA)
Web Links
Selected Publications
Atypical intraductal proliferation (AIP) of the prostate: Findings in repeat biopsy or radical prostatectomy in patients who met pathologic criteria for active surveillance
Lin R, Li H, Baraban E, Lotan T, DeMarzo A, Argani P, Baras A, Matoso A. Hum Pathol 13:105841, Jun 2025. doi: 10.1016/j.humpath.2025.105841. PMID: 40516578.
Tumor infiltrating T-cells and loss of expression of SWI/SNF genes in varying stages of clear cell renal cell carcinoma
Hrizat AS, Lin R, Eberle-Singh J, O'Neill R, Xia Y, Testa JR, Uzzo R, McCue PA, Yang H, Li L., Pathol Res Pract. 266(): 155774, 2025, PMID:39693721
Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification.
Lin R, Flerova E, Wamsley CE, McCue PA, Lallas CD, Jiang W, Huang J, Wang ZX, Li L., Genes Chromosomes Cancer 62(6): 353-360, 2023. PMID:36704911
Pilocytic astrocytoma harboring a novel GNAI3-BRAF fusion.
Lin R, Kenyon A, Wang ZX, Cai J, Iacovitti L, Kenyon LC. Neuropathology 43(5): 391-395, 2023. PMID:36786200
Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapy.
Lin R, Mallick AB, Wang ZX, Brown SA, Lu B, Jiang W., Diagn Pathol. 18(1): 116, 2023, PMID:37865792
Patient with multiple genetically distinct thyroid nodules including papillary thyroid carcinoma harboring novel YWHAG-BRAF fusion.
Lin R, Wang ZX, Cottrill E, Badjatia N, Gargano SM. Cancer Genet 266-267:51-56, Aug 2022. doi: 10.1016/j.cancergen.2022.06.006. Epub 2022 Jun 26. PMID: 35780657.
Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain
Lin R, Cai J, Kenyon L, Iozzo R, Rosenwasser R, Iacovitti L. Stem Cells 37(3):395-406, Mar 2019. doi: 10.1002/stem.2947. Epub 2018 Dec 30. PMID: 30431198; PMCID: PMC7028145.
A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer
Han D, Wu J, Han Y, Wei M, Han S, Lin R, Sun Z, Yang F, Jiao D, Xie P, Zhang L, Yang AG, Zhao A, Wen W, Qin W. Oncotarget 7(37):59471-59481, Sep 2016. doi: 10.18632/oncotarget.10697. PMID: 27448970; PMCID: PMC5312325.
Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke
Lin R, Lang M, Heinsinger N, Stricsek G, Zhang J, Iozzo R, Rosenwasser R, Iacovitti L. Neurobiol Dis 115:49-58, Jul 2018. doi: 10.1016/j.nbd.2018.03.013. Epub 2018 Mar 29. PMID: 29605425.
Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats
Lin R, Cai J, Kostuk EW, Rosenwasser R, Iacovitti L. J Neuroinflammation 13(1):269, Oct 2016. doi: 10.1186/s12974-016-0733-1. PMID: 27733178; PMCID: PMC5062839.
