PEOPLE

Adam Bagg, MD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
7.103 Founders Pavilion
3400 Spruce Street
Philadelphia, PA, 19104-4283
Office: 215-662-4280
Fax: 215-662-7529

Specialty Division

Precision and Computational Diagnostics, Hematopathology

Research Expertise

Molecular genetics and pathology of Leukemias and Lymphomas; Myelodysplastic syndromes; Minimal residual disease; Hodgkin lymphoma

Clinical Expertise

Laboratory Hematology; Laboratory Evaluation of Hematologic Diseases; Leukemias; Lymphomas; Myelodysplastic Syndromes; Molecular Pathology; Myeloma; Hodgkin lymphoma

Itmat Expertise

Dr. Bagg studies: (1) the diagnostic molecular pathology of hematologic malignancies, with the development of novel assays to facilitate their diagnosis; (2) minimal residual disease testing in leukemia, lymphoma and myeloma; and (3) unraveling the biology and improving the laboratory diagnosis of the myelodysplastic syndromes.

Education

MB. BCh (magna cum laude), University of the Witwatersrand, South Africa, Top 1% of graduating class, 1981

Specialty Certification

Hematology/Hematopathology, The South African Medical and Dental Council, 1988
Clinical Pathology, The American Board of Pathology, 1992
Hematology/Hematopathology, The American Board of Pathology, 1999

Postgraduate Training

Intern in Internal Medicine and General Surgery, Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa, 1982-1982
Medical Officer in Internal Medicine, 1 Military Hospital, Pretoria, South Africa, 1983-1984
Resident in Hematology/Hematopathology, University of the Witwatersrand and the South African Institute for Medical Research, Johannesburg,, 1985-1988
Resident in Clinical Pathology, Georgetown University, Washington, D.C, 1989-1992
Fellow in Hematopathology, Georgetown University, Washington, D.C, 1992-1993

Awards and Honors

Isaac Kushlick Memorial Prize, Most distinguished student in Physics, 1976
Alan Rubensohn Memorial Award, Most distinguished first year Medical student, 1976
Convocation Merit Scholarship for Academic Achievement, 1977
A.H. Wadee Memorial Medal, Most distinguished student in Anatomy, 1977
Arthur Aitken Scholarship for Academic Merit, 1977-1979
Hajee Suliman Ebrahim Memorial Trust Gold Medal, Most distinguished student in Physiology, 1978
S.L. Sive Prize, Best performance in Clinical Pathology, 1979
Dallas MacKenzie Prize, Most distinguished student in Community Pediatrics, 1981
Samuel and Sylvia Schnaid Scholarship for academic excellence, 1986-1988
James Gear Prize, Most distinguished graduate resident of the School of Pathology of the University of the Witwatersrand and the South African Institute for Medical Research, 1988
South African Medical Research Council Overseas Post-Doctoral Scholarship, 1989-1991
Watkins Pitchford Memorial Prize South African Institute for Medical Research - Best published paper, 1989
Cecil John Adams Memorial Trust Fellowship, 1989-1991
Washington Society of Pathologists Award
Oral Presentation at Annual Meeting, 1991
Phyllis Knocker/Bradlow Award, College of Medicine of South Africa -Exceptional performance in the national specialty board examination (encompassing all medical specialties), with subsequent contributions to basic or clinical research, 1991
Special Fellowship of the Leukemia Society of America, 1992-1995
Golden Apple Award Nomination, Class of 1995, Georgetown University Medical School, 1993
Visiting Professorship, University of Iowa, 1995
Golden Apple Award Nomination, Class of 1998, Georgetown University Medical School, 1996
Teacher of the Year Award, Department of Pathology, Georgetown University, 1997
Golden Apple Award Nomination, Class of 2000, Georgetown University Medical School, 1998
Osler Institute (National Board Review) Teaching Award, Pathology Course Lecture - White Cell Disorders (for 1995, awarded 1998), 1998
Callender-Binford Lectureship, Armed Forces Institute of Pathology, 1999
Golden Apple Award Nomination, Class of 2001, Georgetown University Medical School, 1999
Kevin E. Salhany Resident Teaching Award
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2000
Research Recognition Award
Leukemia and Lymphoma Society of America, 2002
Teaching Award for National Board Review Course, Osler Institute, 2003
Senior Author on Poster for "Pathologist-In-Training" Award to Sindhu Cherian, Society of Hematopathology, USCAP Annual Meeting, 2004
"Outstanding Faculty", Dean’s Report, University of Pennsylvania School of Medicine, 2005
Senior Author on Platform Presentation for the ”Paul E. Standjord Young Investigator Award for 2006” at the Annual Meeting of the Academy of Clinical Physicians and Scientists To Michele Roullet, MD, 2006
Faculty Sponsor for College of American Pathologists Foundation Advanced Training Grant to Kun Ru, MD, PhD, 2006
International Union Against Cancer (UICC, Geneva Switzerland) Award (NIH funded) to teach in China, 2006
Visiting Professor
Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, 2007
Teaching Award for National Board Review Course, Osler Institute, 2008
America’s Top Doctors for Cancer, Castle Connolly, 2009
Visiting Professor, University of New Mexico, 2009
Senior Author on Presentation accepted/nominated for the Stowell Orbison Award at the Annual Meeting of the United States and Canadian Academy of Pathology, to Rebecca King, MD, 2009
Annual Resident Lecture Award
Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, 2009
America’s Top Doctors, Castle Connolly, 2010
Top Doctor in Philadelphia, Philadelphia Magazine, 2010
America’s Top Doctors for Cancer, Castle Connolly, 2010
Kevin E. Salhany Resident Teaching Award Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2010
America’s Top Doctors for Cancer, Castle Connolly, 2011
Top Doctor in Philadelphia, Philadelphia Magazine, 2011
Co-author on the most downloaded manuscript in Science Translational Medicine in 2011, 2012
Co-author on a top scoring abstract (platform presentation) at the Annual Meeting of the International Society for Laboratory Hematology, Nice, France, 2012
Top 1% of Doctors in the United States, US News and World Report, 2012
Top Doctor in Philadelphia, Philadelphia Magazine, 2012
Visiting Professorship, Emory University, 2012
Co-Author on American Society of Hematology Abstract Achievement Award for a trainee presenter, 54th ASH Annual Meeting, Atlanta, GA, to Grant Nybakken, 2012
Visiting Professor, University of California, San Diego, 2013
Top Doctor in America, US News and World Report, 2013
Visiting Professor, Stanford University, 2013
Outstanding Speaker Award (for 2012), American Association of Clinical Chemistry, 2013
Top Doctor in Philadelphia, Philadelphia Magazine, 2013
First Prize in Pathology category, British Medical Association Book Award, for Knowles Neoplastic Hematopathology (in which I senior authored a chapter), 2014
America’s Top Doctors, Castle Connolly, 2014
America’s Top Doctors for Cancer, Castle Connolly, 2014
Top Doctor in Philadelphia, Philadelphia Magazine, 2014
America’s Top Doctors, Castle Connolly, 2015
America's Top Doctors, Newsweek Magazine, 2015
Top Doctor in Philadelphia, Philadelphia Magazine, 2015
America’s Top Doctors for Cancer, Castle Connolly, 2015
Top Doctor in Philadelphia, Philadelphia Magazine, 2016
Annual Resident Lecture Award, Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, 2017
Top Doctor in Philadelphia, Philadelphia Magazine, 2017

Memberships and Professional Organizations

Society of Hematopathology, 1991 - Present
American Association for Cancer Research, 1993 - Present
American Society of Hematology, 1993 - Present
Member, 1994 - 1999
Association for Molecular Pathology, 1995 - Present
Hematopathology Representative (international election), 1996 - 1997
Invited Member, 1997 - 1997
College of American Pathologists Local Laboratory Inspector, 1997 - 1997
United States and Canadian Academy of Pathology, 1997 - Present
College of American Pathologists Local Laboratory Inspector, 1998 - 1998
Chair-Elect, Hematopathology Section (international election), 1999 - 1999
Chair, Hematopathology Section (international election), 2000 - 2000
Association for Molecular Pathology, 2001 - 2001
Clinical Hematology Laboratories, Mount Sinai Hospital, New York City, 2002 - 2002
National Institutes of Health, 2005 - 2005
Hematopathology Service, Boca Raton Regional Hospital, Boca Raton, FL, 2005 - Present
American Society for Investigative Pathology, 2006 - 2008
United States and Canadian Academy of Pathology

Invited Member, Education Committee, 2006 - 2010
Amgen, Inc., 2006 - 2006
United States and Canadian Academy of Pathology, 2007 - 2010
Medical University of South Carolina, Charleston, SC, 2008 - 2008
United States and Canadian Academy of Pathology, 2009 - 2010
Celgene and Genzyme Genetics, 2009 - 2009
United States and Canadian Academy of Pathology, 2010 - 2012
Paroxysmal Nocturnal Hemoglobinuria Diagnostic Testing Advisory Board, 2010 - 2010
United States and Canadian Academy of Pathology, 2010 - 2010
Personalized Cancer Treatment, John Hopkins University, Baltimore, MD, 2010 - 2010
United States and Canadian Academy of Pathology, 2011 - 2012
United States and Canadian Academy of Pathology, 2011 - 2014
Food and Drug Administration, 2012 - 2012
United States and Canadian Academy of Pathology, 2016 - 2018

Web Links


Selected Publications

Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified from reactive idiopathic hypereosinophilic syndrome.

Wang SA, Hasserjian RP, Tam W, Tsai AG, Geyer JT, George TI, Foucar K, Rogers HJ, Hsi ED, Rea BA, Bagg A, Bueso-Ramos C, Arber DA, Verstovsek S, Orazi A, Haematologica, 2017

Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia.

Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A, Mod Pathol, 2017

BRAF kinase domain mutations in de novo acute myeloid leukemia with monocytic differentiation.

Xu Y, Wertheim G, Morrissette JJ, Bagg A, Leukemia Lymphoma 58(3): 743-745, 2017

International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS, Blood 129(): 1646-1657, 2017

Demystifying the Diagnosis and Classification of Lymphoma: A Hematologist/Oncologist's Guide to the Hematopathologist's Galaxy.

Caponetti G, Bagg A, Journal of Community and Supportive Oncology 15(): 43-48, 2017

NPM1 for MRD? Droplet Like It’s Hot.

Wertheim GBW, Bagg A, Journal of Molecular Diagnosis 19(): 498-501, 2017

Most Myeloid Neoplasms with Deletion of Chromosome 16q are distinct from Acute Myeloid Leukemia with inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study.

Rogers HJ, Hsi ED, Tang G, Wang SA, Bueso-Ramos CE, Lubin D, Morrissette JJ, Bagg A, Cherukuri DP, George TI, Peterson L, Liu YC, Mathew S, Orazi A, Hasserjian RP, Am J Clin Pathol 147(): 411-419, 2017

Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified.

Wang Sa A, Tam Wayne, Tsai Albert G, Arber Daniel A, Hasserjian Robert P, Geyer Julia T, George Tracy I, Czuchlewski David R, Foucar Kathryn, Rogers Heesun J, Hsi Eric D, Bryan Rea B, Bagg Adam, Dal Cin Paola, Zhao Chong, Kelley Todd W, Verstovsek Srdan, Bueso-Ramos Carlos, Orazi Attilio, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016, PMID:27174585

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Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T cell therapy.

Bhoj Vijay G, Arhontoulis Dimitrios, Wertheim Gerald, Capobianchi James, Callahan Colleen A, Ellebrecht Christoph T, Obstfeld Amrom E, Lacey Simon F, Melenhorst Jan J, Nazimuddin Farzana, Hwang Wei-Ting, Maude Shannon L, Wasik Mariusz A, Bagg Adam, Schuster Stephen, Feldman Michael D, Porter David L, Grupp Stephen A, June Carl H, Milone Michael C, Blood, 2016, PMID:27166358

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FLT3 Inhibitor-Associated Neutrophilic Dermatoses.

Varadarajan Nisha, Boni Andrea, Elder David E, Bagg Adam, Micheletti Robert, Perl Alexander E, Rosenbach Misha, JAMA dermatology 152(4): 480-2, 2016, PMID:26886840

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