PEOPLE

Khalil Bdeir, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact Information505c Stellar Chance Bldg.
422 Curie Blvd
Department of Pathology and Laboratory Medicine
Perelman School of Medicine
University of Pennsylvania

Philadelphia, PA, 19104/6082
Office: 215-898-2428
Fax: 215-573-0252

Email: bdeir@pennmedicine.upenn.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

The main focus of my research has been on the link between inflammation and thrombosis, with an emphasis on the pathobiology of alpha-defensins, plasminogen activator system and recently developmental endothelial locus-1 (Del-1) and its role in chronic and acute thrombo-inflammatory diseases like thrombotic stroke, acute chest syndrome (ACS) in sickle cell disease. I was among the first to characterize a transgenic mouse that expresses human alpha-defensins in its neutrophils. It has been our underlying hypothesis that the lack of alpha-defensins in mouse neutrophils, the most abundant protein secreted by their activated human counterparts, together with the rapid apoptosis that these cells undergo in tissue, has led to an under-appreciation of their role in inflammatory and thrombotic disorders. I have extensive experience in the production, purification and characterization of human alpha defensins and Del-1 and diverse in vivo animal models of thrombosis, pulmonary embolism, acute lung injury, and ischemic stroke. My recent focus is the role of Del-1 as a pulmonary endothelial cell derived negative regulator of inflammation in the pathogenesis of ACS. My collaborators provided me with Del-1 knock out and over-expressors mice, and I have generated a novel CRISPR mouse with a single amino acid mutation essential for integrin binding and function of Del-1.

Itmat Expertise

Dr. Bdeir studies the role of plasminogen activators and neutrophil-defensins in the development of atherosclerosis, angiogenesis and acute lung injury and the mechanism of these effects using in-vitro and in-vivo models that will potentially lead to translational therapy.

Education

B.Sc.Pharm (Pharmacy), Hebrew Univ. of Jerusalem, School of Pharmacy, Jerusalem, Israel, 1987
M.Sc.Pham (Pharmacokinetics and Pharmacodynamics), Hebrew Univ. of Jerusalem, School of Pharmacy, Jerusalem, Israel, 1990
PhD (Biochemistry and Pharmacology), Hebrew Univ. of Jerusalem, Hadassah Medical School, Jerusalem, Israel, 1996

Specialty Certification

Postgraduate Training

Post-doctoral Researcher in Pathology and Laboratory Medicine, PSOM, 1996-1998

Awards and Honors

Medical faculty prize for distinction in M.Sc. research, Hebrew University, Israel., 1989
American Heart Association Pennsylvania & Delaware Affiliate award for outstanding effort in the area of research and education in the fight against heart diseases and stroke., 2001

Memberships and Professional Organizations

American Heart Association, 2004 - Present
American Heart Association and American Stroke Association, 2006 - Present
International Society for Fibrinolysis & Proteolysis (ISFP), 2006 - 2009
International Society on Thrombosis and Haemostasis (ISTH), 2007 - Present
Society for Leukocyte Biology (SLB), 2008 - Present
American Thoracic Society (ATS), 2009 - Present
NIH Review Study 2016
NIH is interested in improving their grant review process. An NIH-funded study intended to assess how peer reviewers evaluate R01 grant proposals., 2016 - Present

Web Links


Selected Publications