MacLean Nasrallah, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationHospital of the University of Pennsylvania
3400 Spruce St.
Philadelphia, PA 19104

Specialty Division


Research Expertise

brain development
mouse models
in utero electroporation in mouse models
molecular biology

Itmat Expertise

Brain tumors
Neuropathology and Genetic/molecular pathology advances

Clinical Expertise

molecular pathology of neuropathology


AB (Mathematics), Harvard University, 1997
PhD (Neuroscience), University of Pennsylvania, 2010
MD University of Pennsylvania, 2012

Specialty Certification

Anatomic Pathology and Neuropathology, American Board of Pathology, 2016

Postgraduate Training

Resident in Anatomic Pathology, Hospital of the University of Pennsylvania, 2012-2014
Fellow in Neuropathology, Hospital of the University of Pennsylvania, 2014-2016

Awards and Honors

ASCP Academic Excellence and Achievement in Pathology award, 2012

Memberships and Professional Organizations

United States and Canadian Academy of Pathology, 2013 - Present
Association for Pathology Informatics, 2013 - Present
American Society for Clinical Pathology, 2013 - Present
Association for Molecular Pathology, 2015 - Present
American Association of Neuropathologists, 2015 - Present

Web Links

Selected Publications

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.

Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C, Scientific Reports, 2018

Comparison of chemoradiotherapy with radiotherapy alone for "biopsy only" anaplastic astrocytoma

Wu J, Zou T, Bai HX, Li X, Zhang Z, Xiao B, Nasrallah M, Karakousis G, Cao Y, Zhang PJ, Yang L, Oncotarget 8(40): 69038-69046, 2017, PMID:28978179

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Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations

Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC, J Neuroimaging 5(): 531-538, 2017, PMID:28098958

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The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma

Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK, PLoS One 12(7): e0182034, 2017, PMID:28738091

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19-year-old male with headaches and a possible seizure

Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M, Brain Pathol 27(4): 557-558, 2017, PMID:28585383

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV, Sci Transl Med 9(): 399, 2017, PMID:28724573

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Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H, J Transl Med 14(1): 274, 2016, PMID:27659543

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Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature

Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK, World Neurosurg 92(): 588, 2016, PMID:26852709

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Developmental interneuron subtype deficits after targeted loss of Arx

Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen C, McCoy A, Golden JA, BMC Neurosci 17(1): 35, 2016, PMID:27287386

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