MacLean Nasrallah, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Associate Vice Chair for Research
Contact InformationHospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
6 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Specialty Division
Neuropathology, Neuropathology and Neurodegeneration
Research Expertise
Brain development, mouse models, in utero electroporation in mouse models, molecular biology
Itmat Expertise
Brain tumors, neuropathology and genetic/molecular pathology advances
Clinical Expertise
Neuropathology, molecular pathology of neuropathology
Education
AB (Mathematics), Harvard University, 1997
PhD (Neuroscience), University of Pennsylvania, 2010
MD (Medicine), Perelman School of Medicine at the University of Pennsylvania, 2012
Specialty Certification
Anatomic Pathology and Neuropathology, American Board of Pathology, 2016
Postgraduate Training
Resident, Anatomic Pathology, Hospital of the University of Pennsylvania, 2012-14
Fellow, Neuropathology, Hospital of the University of Pennsylvania, 2014-16
Awards and Honors
Academic Excellence and Achievement in Pathology Award, American Society for Clinical Pathology, 2012
Moore Award for Best Paper on Clinico-Pathological Correlation, American Association of Neuropathologists, 2023
Memberships and Professional Organizations
American Society for Clinical Pathology, 2013-16 (Annual Meeting Scientific Program Committee, Neuropathology Subcommittee, 2015-16)
United States and Canadian Academy of Pathology, 2013-16
Association for Pathology Informatics, 2013-15
Association for Molecular Pathology, 2015-17
American Association of Neuropathologists, 2015-present (Professional Affairs Committee, 2019-present)
Society for NeuroOncology, 2017-present (Co-Chair, Molecular Pathology Special Interest Track, 2023)
Glioblastoma Multiforme Translational Center of Excellence, Abramson Cancer Center, Penn Medicine, 2018-present
American Academy of Neurology, Residency Examination Advisory Panel, 2019-present
Glioma Longitudinal AnalySiS (GLASS) Consortium, 2020-present
Penn Neuro-Oncology Disease Team Leadership Council, 2020-present
ReSPOND (Radiomics Signatures for PrecisiON Diagnostics) Consortium on Glioblastoma, 2020-present
Response Assessment in Neuro-Oncology (RANO) Recurrent Glioma Pathology Working Group, 2020-present
National Cancer Institute, Clinical Proteomic Tumor Analysis Consortium, 2022-present
NRG Oncology, Neuropathology Expert Group, 2022-present
Web Links
Selected Publications
SETD2 mutations in primary central nervous system tumors
Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP, Acta Neuropathol Commun 6(1): 123, 2018, PMID:30419952
Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma
Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP, J Neurooncology 141(2): 421-429, 2019, PMID:30446903
Epidermal growth factor receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development
Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM, Cancer Cell 34(1): 163-177, 2018, PMID:29990498
In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature
Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C, Neuro Oncol 20(8): 1068-1079, 2018, PMID:29617843
Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.
Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C, Sci Rep 8(1): 5087, 2018, PMID:29572492
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV, Sci Transl Med 9(399): 399, 2017, PMID:28724573
The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma
Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK, PLoS One 12(7): e0182034, 2017, PMID:28738091
Folate receptor overexpression in human and canine meningiomas-immunohistochemistry and case report of intraoperative molecular imaging
Pierce JT, Cho SS, Nag S, Zeh R, Jeon J, Holt D, Durham A, Nasrallah MP, Singhal S, Lee JYK, Neurosurgery 85(3): 359-368, 2019, PMID:30113687
Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression
Nasrallah MP, Cho G, Simonet JC, Putt ME, Kitamura K, Golden JA, Hum Mol Genet 21(5): 1090-8, 2012, PMID:22108177
Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature
Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK, World Neurosurg 92(no issue): 588.e17-588.e21, 2016, PMID:26852709
Lis1 is necessary for normal non-radial migration of inhibitory interneurons
McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA, Am J Pathol 165(3): 775-84, 2004, PMID:15331402
Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla
Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H, J Transl Med 14(1): 274, 2016, PMID:27659543
Developmental interneuron subtype deficits after targeted loss of Arx
Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen CN, McCoy A, Golden JA, BMC Neurosci 17(1): 35, 2016, PMID:27287386
19-year-old male with headaches and a possible seizure
Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M, Brain Pathol 27(4): 557-558, 2017, PMID:28585383
Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency
Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM, Fadugba O, J Clin Immunol 38(6): 642–645, 2018, PMID:30159811
Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations
Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC, J Neuroimaging 5(): 531-538, 2017, PMID:28098958
Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations
Cho G, Nasrallah MP, Lim Y, Golden JA, Neurogenetics 13(1): 23-9, 2012, PMID:22252899
Interneuron deficits in patients with the Miller-Dieker syndrome
Pancoast M, Dobyns W, Golden JA, Acta Neuropathol 109(4): 400-4, 2005, PMID:15739099
Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice
Nasrallah IM, McManus MF, Pancoast MM, Wynshaw-Boris A, Golden JA, J Comp Neurol 496(6): 847-58, 2006, PMID:16628622
