Douglas B. Cines, MD

Professor of Medicine, Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Director, Coagulation Laboratory

Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012


Specialty Division

Laboratory Medicine, Immunobiology and Experimental Pathology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.


A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972

Specialty Certification

American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980

Postgraduate Training

Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
Academy of Clinical Laboratory Physicians and Scientists, 1990
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
American Association of University Pathologists, 1995
Biennial Award for Contributions to Hemostasis Research (BACH), International Society on Thrombosis and Haemostasis (ISTH), 2017

Memberships and Professional Organizations

American Society of Hematology, 1980 - Present
American Federation for Clinical Research, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Society of Hematology, 1986 - 1991
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
American Society of Hematology, 1992 - 1993
Philadelphia Hematology Society, 1992 - 2000
American Society of Hematology, 1999 - 2002
International Society on Thrombosis and Haemostasis., 2000 - 2006
Federation of Clinical Immunology Societies, 2002 - Present
US Food and Drug Administration, 2004 - 2005
American Association of Immunologists, 2004 - Present
Platelet Disorder Support Association, 2004 - Present
International Society of Thrombosis and Haemostasis., 2007 - 2012
American Society of Hematology, 2010 - 2012
US Department of Justice, Vaccine Division, 2011 - 2012
American Society of Hematology, 2012 - Present
American Society of Hematology, 2015 - Present
American Society of Hematology, 2015 - Present

Web Links

Selected Publications

Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists.

Pishko Allyson M, Misgav Mudi, Cuker Adam, Cines Douglas B, George James N, Vesely Sara K, Terrell Deirdra R, Journal of thrombosis and thrombolysis 46(1): 24-30, 2018, PMID:29582213

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Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Dai Jing, Madeeva Daria, Hayes Vincent, Ahn Hyun Sook, Tutwiler Valerie, Arepally Gowthami M, Cines Douglas B, Poncz Mortimer, Rauova Lubica, Blood, 2018, PMID:29914979

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Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B, Translational stroke research, 2018, PMID:29476447

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Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R, Blood advances 2(3): 165-176, 2018, PMID:29365311

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Targeting Plasminogen Activator Inhibitor 1 in Tetracycline-Induced Pleural Injury in Rabbits

Florova, G., Azghani, A., Karandashova, S., Schaefer, C., Yarovoi S.V., Declerck, P.J., Cines, D.B., Idell, S. and Komissarov, A.A., Am J Physiol Lung Cell Molec Physiol 314(1): L54-L68, 2018, PMID:28860148

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Pathogenesis of heparin-induced thrombocytopenia

Raouva, L., Arepally, G., Poncz, M. and Cines, D.B, Autoimmunity Reviews, 2018

T2 magnetic resonance to monitor hemostasis

108. Cuker, C., Marturano, J.E., Carinato, M., Lowery, T.J. and Cines, D.B., Seminars in Haemostasis and Thrombosis, 2018

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R., Blood Advances 1(18): 1452-65, 2017

Thrombocytopenia in pregnancy

Cines D.B., Levine L.D., Blood, 2017, PMID:28637667

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Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT).

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L., ISTH. Berlin, Germany, 2017