Douglas B. Cines, MD

Professor of Medicine, Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Director, Coagulation Laboratory; Director, Office of Faculty Development

Contact InformationDept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012


Specialty Division

Laboratory Medicine, Immunobiology and Experimental Pathology

Research Expertise

Thrombosis, fibrinolysis, vascular biology, immunohematology

Clinical Expertise

Coagulation, immune hematological disorders

Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.


A.B. (History, PreMed), New York University, 1968
M.D. (Medicine), New York University School of Medicine, 1972

Specialty Certification

American Board of Internal Medicine, 1975
American Board of Internal Medicine (Hematology), 1980

Postgraduate Training

Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978

Awards and Honors

Phi Beta Kappa , Alpha Omega Alpha, New York University Scholar, 1968
NIH Research Career Development Award, 1979
American Society of Clinical Investigation, 1986
Visiting Scientist, Roche Institute Molecular Biology, 1990-1992
Academy of Clinical Laboratory Physicians and Scientists, 1990
American Association of University Pathologists, 1995
American Society of Hematology, 2004

Memberships and Professional Organizations

American Association for the Advancement of Science, 1980 - Present
American Association for the Advancement of Science, 1980 - Present
American Society of Hematology, 1980 - Present
American Federation for Clinical Research, 1980 - Present
Lupus Foundation of Philadelphia/Del. Valley, 1986 - 2006
Philadelphia Hematology Society, 1992 - 2000
Am. Soc. Hematol. Scientific Subcommittee on Laboratory Medicine, 1999 - 2002
International Society Hemostasis and Thrombosis, 2000 - Present
Federation of Clinical Immunology Societies, 2002 - Present
Food and Drug Administration, 2004 - 2005
American Association of Immunologists, 2004 - Present
Platelet Disorder Support Association, 2004 - Present
US Department of Justice, Vaccine Division (Ad Hoc Consultant), 2011 - 2012

Web Links

Selected Publications

ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Ostertag, E.M., Bdeir K., Kacir S., Thiboutot, M., Gulendran, G., Yunk, L., Hayes, V.M., Poncz, M., Zheng, X.L., Cines, D.B. and Siegel, D.L., Transfusion 56(7): 1775-85, 2016

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

Cai Z, Zhu Z, Greene MI, Cines DB., Autoimmun. 15(7): 752-5, 2016

Urokinase-type plasminogen activator (uPA) promotes angiogenesis by attenuating proline-rich homeobox (PRH) transcription factor activity and de-repressing vascular endothelial cell growth factor (VEGF) receptor expression.

Stepanova, V., Jayaraman, P.S., Zaitsev, S.V., Lebeda, T., Bdeir, Kh., Kershaw, R., Holman, K., Parfyonova, Y.V., Semina, E., Beloglazova, I., Boldyreva, M. Tkachuk, V.S. and Cines, D.B., J. Biol. Chem. 291(29): 15029-45, 2016, PMID:27151212

Read article

ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

Ostertag, E.M., Kacir, S., Thiboutot, M.C, Gueldran, G., Zheng, X. L., Cines, D.B. and Siegel, D.L., Transfusion 56(7): 1763-74, 2016, PMID:27040144

Read article

Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment.

Parker, Z.F., Rux, A.H., Riblett, A.M., Lee, F.-H., Rauova, L., Cines, D.B., Poncz, M., Sachais, B.S., and Doms, R.W., AIDS Research and Human Retroviruses. 32(7): 705-17, 2016, PMID:26847431

Read article

Controversies in the treatment of immune thrombocytopenia.

Cuker, A., Cines, D.B. and Neunert, C.E., Current Opinion in Hematology, 2016, PMID:27380558

Read article

Human neutrophil peptides (HNPs) inhibit proteolytic cleavage of von Willebrand factor by ADAMTS13: a potential trigger for thrombotic thrombocytopenic purpura.

Pillai, V.G., Bao, J., Zander, C.B., McDaniel, J.K., Cao, W., Chetty, P.S., Seeholzer, S.G. Bdeir, Kh., Cines, D.B. and Zheng, X.L., Blood 128(1): 110-9, 2016

alpha-defensin promotes vascular deposition of LDL.

Abu-Fanne, R., Adb-Elrahman, I., Hankin, A., Blum, G., Basheer, M., Hojazi, N., Cines, D.B., Maraga, E., and Higazi, A.A.-R, J. Biol. Chem. 291(6): 2777-86, 2016

A platelet-targeted urokinase prodrug as a novel thromboprophylactic agent.

Fuentes, R.E., Zaitsev, S., Ahn, H.-S., Hayes, V. H., Kowalska, M.A., Lambert, M.E., Wang, Y., Siegel, D. L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R. and Poncz, M., J. Clin. Invest 126(2): 483-494, 2016, PMID:26690701

Read article

Kinetics and mechanics of clot contraction are governed by molecular and cellular blood composition.

Tutwiler, V., Litvinov, R.I., Lozhkin, A. P., Pershova, A.D., Lebedeva, T., Ataullakhanov, F.I., Spiller, K.L., Cines, D.B, and Weisel, J.W., Blood 127(1): 149-59, 2016, PMID:26603837

Read article