Adam C. Cuker, MD, MS
Assistant Professor of Medicine in the Dep't of Pathology and Laboratory Medicine, secondary
University of Pennsylvania Perelman School of Medicine
Contact InformationPenn Comprehensive Hemophilia and Thrombosis Program
HUP, 3 Dulles
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-8012
Fax: 215-615-6599
Specialty Division
Laboratory Medicine
Research Expertise
Heparin-induced thrombocytopenia, Immune thrombocytopenia, Thrombosis, Anticoagulation, Platelet disorders, Bleeding disorders
Itmat Expertise
Hemostasis and thrombosis.
Clinical Expertise
Clotting disorders, Bleeding disorders, Platelet disorders
Education
BS (Biological Sciences), Cornell University, 1998
MD (Medicine), Yale University, 2003
MS (Translational Research), University of Pennsylvania, 2010
Specialty Certification
American Board of Internal Medicine, 2006
American Board of Internal Medicine, Hematology, initial certification, 2009
American Board of Internal Medicine, Hematology, recertification, 2019
Postgraduate Training
Intern in Internal Medicine, Brigham and Women's Hospital, 2003-2004
Resident in Internal Medicine, Brigham and Women's Hospital, 2004-2006
Fellow in Hematology/Oncology, University of Pennsylvania, 2006-2009
Leading Success Leadership Training, University of Pennsylvania, 2015-2016
Enhancing Leadership 2.0, University of Pennsylvania, Department of Medicine, 2020-2020
Awards and Honors
Medical Student Research Training Fellowship, National Institutes of Health, 1999-1999
Farr Scholarship, Yale University, 2000
Medical Student Research Training Fellowship, Howard Hughes Medical Institute, 2000-2001
Medical Student Research Continued Support Fellowship, Howard Hughes Medical Institute, 2001-2003
Jane Alavi Outstanding Fellow in Hematology/Oncology, University of Pennsylvania, 2007
Clinical Loan Repayment Award, National Institutes of Health, 2008-2010
Haemophilia Academy Award, Haemophilia Academy, 2008
Clinical Research Training Institute, American Society of Hematology, 2008-2009
Outstanding Peer Reviewer Award, Pharmacoepidemiology and Drug Safety, 2009
Austrian Award, Department of Medicine, 2010
Eberhard Mammen Young Investigator Award, Seminars in Thrombosis and Hemostasis, 2011
Outstanding peer reviewer, Annals of Internal Medicine, 2011
Outstanding peer reviewer, Annals of Internal Medicine, 2012
Gift of Life Award, Ree Wynn Foundation, 2013
Outstanding peer reviewer, Annals of Internal Medicine, 2013
Cuker A et al., Blood 2012;120:4160 featured as one of 4 hematology articles in Update in Hematology and Oncology: Evidence Published in 2012, Annals of Internal Medicine, 2013
Outstanding peer reviewer, Annals of Internal Medicine, 2014
The John Glick, MD Prize for Teaching Excellence in Oncology, University of Pennsylvania, 2015
Faculty, American Society of Hematology Clinical Research Training Institute, 2015
Outstanding peer reviewer, Annals of Internal Medicine, 2016
Outstanding speaker award, American Association for Clinical Chemistry, 2016
Castle Connolly Top Doctor of Philadelphia, 2017
Outstanding peer reviewer, Annals of Internal Medicine, 2017
HemeOnc Today Next Gen Innovator, 2017
Eberhard Mammen Seminars in Thrombosis and Hemostasis 2018 Most Popular Article Award for Cuker A. et al., Semin Thromb Hemost 2014;40:106., 2018
Eberhard Mammen Seminars in Thrombosis and Hemostasis 2018 Most Popular Article Award for Cuker A. et al., Semin Thromb Hemost 2015;41:395., 2018
Castle Connolly Top Doctor of Philadelphia, 2018
Top Doctor, Philadelphia Magazine, 2018
Top Doctor, Philadelphia Magazine, 2019
“World Expert” (representing the top 0.1% of researchers in “thrombocytopenia”), Expertscape, 2019
Castle Connolly Top Doctor of Philadelphia, 2019
Outstanding peer reviewer, Annals of Internal Medicine, 2019
Outstanding peer reviewer, Annals of Internal Medicine, 2020
Top Doctor, Philadelphia Magazine, 2020
“World Expert”, Expertscape, representing the top 0.1% of researchers in “platelet disorders” and “ITP”, 2020
Castle Connolly Top Doctor of Philadelphia, 2020
The DuPont Guerry Award for Outstanding Mentorship, University of Pennsylvania, Perelman School of Medicine, Division of Hematology/Oncology, 2021
Top Doc, Philadelphia Magazine, 2021
“World Expert”, Expertscape, representing the top 0.1% of researchers in “Blood Platelet Disorders”, 2021
Top Doc, Philadelphia Magazine, 2022
Best articles of the month, Emergency Medical Abstracts (given to Dawwas GK, Leonard CE, Lewis JD, Cuker A; Ann Intern Med 2022;175:20-28.), 2022
American Registry/Castle Connolly Top Doc, 2023
Top Doc, Philadelphia Magazine, 2023
Top Doc, Philadelphia Magazine, 2024
American Registry/Castle Connolly Top Doc, 2024
American Registry/Castle Connolly Top Doc, 2025
Memberships and Professional Organizations
American Society of Hematology, 2006 - Present
National Hemophilia Foundation, 2007 - Present
International Society on Thrombosis and Haemostasis, 2008 - Present
Hemostasis and Thrombosis Research Society, 2008 - Present
American College of Physicians, 2009 - Present
Anticoagulation Forum, 2011 - Present
American Society of Hematology Clinical Research Training Institute, 2011 - Present
Data Safety and Monitoring Committee, Bridging ITP Study, 2013 - 2020
Hemostasis and Thrombosis Research Society Mentored Research Award Program, 2014 - 2014
American College of Cardiology, 2015 - Present
American Thrombosis and Hemostasis Network, 2015 - Present
American Heart Association, 2016 - Present
Netherlands Organization for Health Research and Development, 2022 - 2022
NHLBI, 2022 - 2022
National Heart Lung and Blood Institute, 2023 - 2023
Web Links
Selected Publications
Novel diagnostic assays for heparin-induced thrombocytopenia
Cuker A, Rux AH, Hinds JL, Dela Cruz M, Yarovoi SV, Brown IAM, Yang W, Konkle BA, Arepally GM, Watson SP, Cines DB, Sachais BS, Blood 121(18): 3727-3732, 2013, PMID:23446735
Protamine-induced thrombocytopenia?
Cuker A, Cines DB, Blood 121(): 2818-2819, 2013
Reversal of novel oral anticoagulants in patients with major bleeding
Siegal D, Cuker A, J Thromb Thrombolysis 35(3): 391-398, 2013, PMID:23389753
Similarity in Joint Function Limitation in Type 3 Von Willebrand Disease and Moderate Haemophilia A
Sood S, Cuker A, Wang C, Metjian A, Chiang E, Soucie J, Konkle B, Haemophilia 19(4): 595-601, 2013, PMID:23534856
Investigation of a potential protective mechanism against heparin-induced thrombocytopenia in patients on chronic intermittent hemodialysis
Tanhehco YC, Cuker A, Rudnick M, Sachais BS, Thromb Res 131(3): 244-248, 2013, PMID:23305841
Predictive value of the 4Ts scoring system for heparin-induced thromboctopenia: a systematic review and meta-analysis
Cuker A, Gimotty PA, Crowther MA, Warkentin TE, Blood 120(20): 4160-4167, 2012, PMID:22990018
Dynamic antibody binding properties in the pathogenesis of HIT
Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB, Blood 120(5): 1137-1142, 2012, PMID:22577175
Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism
Martinez M, Cuker A, Mills A, Lightfoot R, Fan Y, Tang W, Hazen SL, Ischiropoulos H, Free Radic Biol Med 53(2): 230-236, 2012, PMID:22580301
How I treat heparin-induced thrombocytopenia
Cuker A, Cines DB, Blood 119(10): 2209-2218, 2012, PMID:22246036
Comtemporary management of primary immune thrombocytopenia (ITP) in adults
Lakshmanan S, Cuker A, J Thromb Haemost 10(10): 1988-1998, 2012, PMID:22863415
